Results 191 to 200 of about 130,723 (312)

Identification of bioactive compounds and molecular targets of Fuke Huahuang formulation to treat vaginitis

Animal Models and Experimental Medicine, EarlyView.
Fuke Huahuang formulation (FHF) is used to treat vaginitis, and it exerts a promising anti‐inflammatory effect in clinical use. However, the detailed components and mechanisms of FHF for treating vaginitis remain unreported, and further preclinical evaluation is required to reveal its potential pharmacological activities against vaginitis.
Huiyu Liu, Jie Mo, Cheng Liang, Qingting Chen, Bin Yang, Jiaqi Liu   +5 more
wiley   +1 more source

Conformational flexibility is a critical factor in designing broad-spectrum human norovirus protease inhibitors. [PDF]

J Virol
Pham S, Zhao B, Neetu N, Sankaran B, Patil K, Ramani S, Song Y, Estes MK, Palzkill T, Prasad BVV.   +9 more
europepmc   +1 more source

Posttraumatic plasma levels of mediators of organ failure [PDF]

, 1988
Dwenger, A., Jochum, Marianne, Joka, T., Redl, H., Schlag, G., Sturm, J.   +5 more
core  

Effects of Dictyophora polysaccharide on cerebellar Purkinje cell degeneration in a chronic alcohol mouse model

Animal Models and Experimental Medicine, EarlyView.
In an ethanol (EtOH)‐treated mouse model, increases in the NLRP3 inflammasome proteins, PC degeneration, and motor coordination disorders were observed. DIP suppressed the NLRP3‐ASC‐caspase‐1 signaling pathway, and alleviated the motor deficits and cerebellar pathological changes in chronic EtOH‐treated mice.
Jian Zhang, Zhihui Dai, Huanhuan Yu, Baofei Sun, Jiuyang Ding, Yuanhe Wang   +5 more
wiley   +1 more source

The Many Faces of Protease-Activated Receptor 2 in Kidney Injury. [PDF]

Biomedicines
Oe Y, Tanaka T, Takahashi N.
europepmc   +1 more source

Calcineurin controls the expression of numerous genes in cerebellar granule cells [PDF]

, 2003
Ashby, Dominique S, Freeman, Tom C, Fresu, Luigia, Genazzani, Armando A, Kramer, Dana   +4 more
core   +1 more source

Inhibitory efficacy and structural insights of Bofutrelvir against SARS-CoV-2 M^pro mutants and MERS-CoV M^pro. [PDF]

Commun Biol
Wang W, Zhou X, Li W, Zeng P, Guo L, Wang Q, Li J.   +6 more
europepmc   +1 more source

Validity of the elastase assay in intensive care medicine [PDF]

, 1988
Fritz, Hans, Jochum, Marianne, Lang, H., Redl, H., Redl, H., Schlag, G.   +5 more
core  

Enantiomerically Enriched Aziridine‐2‐carboxylates via Copper‐Catalyzed Reductive Kinetic Resolution of 2H‐Azirines

Angewandte Chemie International Edition, Accepted Article.
We present the first reductive kinetic resolution of racemic 2H‐azirines to prepare optically enriched N‐H aziridine‐2‐carboxylates, which are bench stable and easily diversifiable building blocks, concomitantly with the corresponding enantiomerically enriched 2H‐azirines. The N‐H aziridines were obtained with excellent diastereoselectivity (>20:1) and
Yinuo Zheng, Elvis Wang Hei NG, Antonio Rizzo, Pauline Chiu   +3 more
wiley   +1 more source

The postsynaptic density in excitatory synapses is composed of clustered, heterogeneous nanoblocks. [PDF]

J Cell Biol
Sun R, Allen JP, Mao Z, Wilson L, Haider M, Alten B, Zhou Z, Wang X, Zhou Q.   +8 more
europepmc   +1 more source