Results 251 to 260 of about 368,214 (310)
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Interactions of HIV protease inhibitors with ATP-dependent drug export proteins.
Molecular Pharmacology, 1999We used renal proximal tubules from a teleost fish (killifish; Fundulus heteroclitus), fluorescent substrates and confocal microscopy to study the interactions between human immunodeficiency virus protease inhibitors and drug-transporting ATPases.
Heike Gutmann +4 more
semanticscholar +1 more source
International Journal of STD & AIDS, 2005
The goal of this study was to develop an evaluation method of antiretroviral treatment adherence from a hospital pharmacy and to identify one or more factors that influenced this adherence, such as patient or treatment characteristics. The HIV patients included in this study were based, for the major part, in Saint-André hospital and collected their ...
M, Rubio +6 more
openaire +2 more sources
The goal of this study was to develop an evaluation method of antiretroviral treatment adherence from a hospital pharmacy and to identify one or more factors that influenced this adherence, such as patient or treatment characteristics. The HIV patients included in this study were based, for the major part, in Saint-André hospital and collected their ...
M, Rubio +6 more
openaire +2 more sources
HIV protease inhibitors: pharmacologic and metabolic distinctions.
AIDS (London, England), 1999In the earlier era of nucleoside analogue antiretroviral therapy, considerations of pharmacologic drug-drug interactions were only a small factor in choosing optimal therapies for patients with HIV infection. However, pharmacologic considerations are critical for selecting and managing the current multiple-drug antiretroviral regimens that include one ...
openaire +1 more source
Journal of Pharmacy Practice, 1997
The introduction of a new class of anti-HIV agents, the protease inhibitors, has given new hope to patients with HIV infection. Use of these agents requires the pharmacist to have a complete knowledge of phar macokinetics, adverse reactions, drug-drug interactions, and resistance profiles.
Catherine M. Oliphant, Scott M. Bonnema
openaire +1 more source
The introduction of a new class of anti-HIV agents, the protease inhibitors, has given new hope to patients with HIV infection. Use of these agents requires the pharmacist to have a complete knowledge of phar macokinetics, adverse reactions, drug-drug interactions, and resistance profiles.
Catherine M. Oliphant, Scott M. Bonnema
openaire +1 more source
Drug Metabolism and Disposition, 2000
HIV protease inhibitors have proven remarkably effective in treating HIV-1 infection. However, some tissues such as the brain and testes (sanctuary sites) are possibly protected from exposure to HIV protease inhibitors due to drug entry being limited by the membrane efflux transporter P-glycoprotein, located in the capillary endothelium.
E F, Choo +6 more
openaire +2 more sources
HIV protease inhibitors have proven remarkably effective in treating HIV-1 infection. However, some tissues such as the brain and testes (sanctuary sites) are possibly protected from exposure to HIV protease inhibitors due to drug entry being limited by the membrane efflux transporter P-glycoprotein, located in the capillary endothelium.
E F, Choo +6 more
openaire +2 more sources
Hodgkin disease: pharmacologic intervention of the CD40-NF kappa B pathway by a protease inhibitor.
Blood, 2000The malignant Reed-Sternberg cell of Hodgkin disease is an aberrant B cell that persists in an immunolgically mediated inflammatory infiltrate. Despite its nonproductive immunoglobulin genes, the Reed-Sternberg cell avoids the usual apoptotic fate of defective immune cells through an unknown mechanism.
C M, Annunziata +4 more
openaire +1 more source
CYP3A5 Genotype has an Impact on the Metabolism of the HIV Protease Inhibitor Saquinavir
Clinical pharmacology and therapy, 2007F. Josephson +11 more
semanticscholar +1 more source