Results 21 to 30 of about 130,723 (312)

Effects of Cordycepin in Cordyceps militaris during Its Infection to Silkworm Larvae

Microorganisms, 2021
Cordyceps militaris produces cordycepin, a secondary metabolite that exhibits numerous bioactive properties. However, cordycepin pharmacology in vivo is not yet understood. In this study, the roles of cordycepin in C.
Tatsuya Kato, Konomi Nishimura, Ahmad Suparmin, Kazuho Ikeo, Enoch Y. Park   +4 more
doaj   +1 more source

Quercetin as a potential treatment for COVID-19-induced acute kidney injury: Based on network pharmacology and molecular docking study.

PLoS ONE, 2021
Kidneys are one of the targets for SARS-CoV-2, it is reported that up to 36% of patients with SARS-CoV-2 infection would develop into acute kidney injury (AKI).
Yue-Yu Gu, Min Zhang, Huan Cen, Yi-Fan Wu, Zhaoyu Lu, Fuhua Lu, Xu-Sheng Liu, Hui-Yao Lan   +7 more
doaj   +1 more source

The intracellular pharmacology of antiretroviral protease inhibitors [PDF]

Journal of Antimicrobial Chemotherapy, 2004
Therapeutic drug monitoring (TDM) of antiretroviral protease inhibitors (PIs) has been suggested to have the potential to both reduce toxicity and optimize individual therapy. However, the major target of PIs is within cells infected with HIV. Therefore clinical outcome ultimately must be related to intracellular drug concentrations since antiviral ...
David Back, Saye Khoo, J. Ford
openaire   +2 more sources

Determination of PAR4 numbers on the surface of human platelets: no effect of the single nucleotide polymorphism rs773902

Platelets, 2021
The thrombin receptor, protease-activated receptor 4 (PAR4), is important for platelet activation and is the target of emerging anti-thrombotic drugs. A frequently occurring single nucleotide polymorphism (SNP; rs773902) causes a function-altering PAR4 ...
Simeng Li, Volga Tarlac, Roberto B. I. Christanto, Shauna L. French, Justin R. Hamilton   +4 more
doaj   +1 more source

Management of Antiretroviral Therapy with Boosted Protease Inhibitors—Darunavir/Ritonavir or Darunavir/Cobicistat

Biomedicines, 2021
A major challenge in the management of antiretroviral therapy (ART) is to improve the patient’s adherence, reducing the burden caused by the high number of drugs that compose the treatment regimens for human immunodeficiency virus positive (HIV ...
Ruxandra-Cristina Marin, Tapan Behl, Nicoleta Negrut, Simona Bungau   +3 more
doaj   +1 more source

Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology

Frontiers in Immunology, 2020
Genetic disruption or short-term pharmacological inhibition of MALT1 protease is effective in several preclinical models of autoimmunity and B cell malignancies. Despite these protective effects, the severe reduction in regulatory T cells (Tregs) and the
Kea Martin, Ursula Junker, Elaine Tritto, Esther Sutter, Tina Rubic-Schneider, Hannah Morgan, Satoru Niwa, Jianping Li, Achim Schlapbach, Dana Walker, Marc Bigaud, Christian Beerli, Amanda Littlewood-Evans, Bettina Rudolph, Marc Laisney, David Ledieu, Karen Beltz, Jean Quancard, Frédéric Bornancin, Natasa Zamurovic Ribrioux, Thomas Calzascia   +20 more
doaj   +1 more source

Treatment of Porphyromonas gulae infection and downstream pathology in the aged dog by lysine-gingipain inhibitor COR388. [PDF]

, 2020
COR388, a small-molecule lysine-gingipain inhibitor, is currently being investigated in a Phase 2/3 clinical trial for Alzheimer's disease (AD) with exploratory endpoints in periodontal disease.
Arastu-Kapur, Shirin, Araujo, Joseph, De Lannoy, Ines AM, Dominy, Stephen S, Ermini, Florian, Haditsch, Ursula, Holsinger, Leslie J, Lynch, Casey, Nguyen, Mai, Raha, Debasish, Ryder, Mark I   +10 more
core   +1 more source

Myricetin, the main flavonoid in Syzygium cumini leaf, is a novel inhibitor of platelet thiol isomerases PDI and ERp5 [PDF]

, 2020
Background: Flavonoids have been characterized as a prominent class of compounds to treat thrombotic diseases through the inhibition of thiol isomerases. Syzygium cumini is a flavonoid-rich medicinal plant that contains myricetin and gallic acid.
Ayyanar, Banno, Bekendam, Bi, Chagas, Chagas, Chang, Chen, Chung, Dang, De Bona, Dutta-Roy, Essex, Essex, Essex, Ghoshal, Giamogante, Giamogante, Holbrook, Inoue, Jarvis, Jasuja, Jayakumar, Jordan, Kang, Kehrel, Kim, Lahav, Lakowicz, Lescano, Lin, Lu, Mangin, Masuda, Navarro-Nuñez, Park, Raffaelli, Raturi, Sharma, Sousa, Stopa, Taylor, Trnkova, Wang, Ware, Wendelboe   +45 more
core   +1 more source

Potential pharmacological candidates Transmembrane protease, serine 2 inhibitors 2019-ncov treatment [PDF]

Ars Pharmaceutica, 2020
ABSTRACT Introduction: Coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus with characteristic of infecting the respiratory tract, causing severe acute respiratory syndrome. The virus uses the ACE II receptors and the transmembrane protein TMPRSS2 initial step to enter the host cell, this contribution described different types of drug ...
Eduardo Arrieta, Snaider Montes-Ucros, Alfredo Montes, Alfredo Montes   +3 more
openaire   +3 more sources

In silico identification of potential natural product inhibitors of human proteases key to SARS-CoV-2 infection [PDF]

Molecules 2020, 25(17), 3822, 2020
Presently, there are no approved drugs or vaccines to treat COVID-19 which has spread to over 200 countries and is responsible for over 3,65,000 deaths worldwide. Recent studies have shown that two human proteases, TMPRSS2 and cathepsin L, play a key role in host cell entry of SARS-CoV-2.
arxiv   +1 more source