Potential pharmacological candidates Transmembrane protease, serine 2 inhibitors 2019-ncov treatment [PDF]
Ars Pharmaceutica, 2020 ABSTRACT Introduction: Coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus with characteristic of infecting the respiratory tract, causing severe acute respiratory syndrome. The virus uses the ACE II receptors and the transmembrane protein TMPRSS2 initial step to enter the host cell, this contribution described different types of drug ...
Eduardo Arrieta +3 more
openaire +3 more sources
KATP Channel Openers Have Opposite Effects on Mitochondrial Respiration Under Different Energetic Conditions [PDF]
, 2008 Mitochondrial (m) KATP channel opening has been implicated in triggering cardiac preconditioning. Its consequence on mitochondrial respiration, however, remains unclear. We investigated the effects of two different KATP channel openers and antagonists on
Camara, Amadou K.S. +5 more
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Evaluation of Platelet Activation by HIV Protease Inhibitors – The HIV-PLA II Study
HIV/AIDS: Research and Palliative Care, 2021 Gerrit Kann,1,* Junaid Owasil,1,* Karina Kuczka,2 Annette Haberl,1 Timo Wolf,1 Pavel Khaykin,1 Sebastian Harder,2 Christoph Stephan,1 Nils von Hentig1 1HIVCENTER, Medical HIV Treatment and Research Unit, Johann Wolfgang Goethe University ...
Kann G +8 more
doaj
Matriptase regulates c-Met mediated proliferation and invasion in inflammatory breast cancer. [PDF]
, 2016 The poor prognosis for patients with inflammatory breast cancer (IBC) compared to patients with other types of breast cancers emphasizes the need to better understand the molecular underpinnings of this disease with the goal of developing effective ...
Boerner, Julie +11 more
core +2 more sources
A brief overview of current drug repurposing approaches for COVID-19 management [PDF]
, 2020 This brief overview is intended to shed light on the current drug repositioning (also called drug repurposing) in the therapeutics of the novel coronavirus disease which emerged in 2019 (COVID-19).
Rodrigues, Pedro da Fonseca Soares +1 more
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Distinct phosphorylation clusters determines the signalling outcome of the free fatty acid receptor FFA4/GPR120 [PDF]
, 2016 It is established that long-chain free fatty acids including ω-3 fatty acids mediate an array of biological responses through members of the free fatty acid receptor family, which includes FFA4.
Alvarez-Curto, Elisa +7 more
core +2 more sources
International Journal of Nanomedicine, 2022 Monica Butnariu,1 Cristina Quispe,2 Niranjan Koirala,3,4 Sujan Khadka,5,6 Carla Marina Salgado-Castillo,7 Muhammad Akram,8 Rabia Anum,9 Balakyz Yeskaliyeva,10 Natália Cruz-Martins,11– 14 Miquel Martorell,15,16 Manoj Kumar,17 Radu Vasile Bagiu,18,19 Ahmad
Butnariu M +15 more
doaj
Future Pharmacology(1) Background: The SARS-CoV-2 papain-like protease (PLpro) remains an underexplored antiviral target so far. The reduced efficacy of approved treatments against novel variants highlights the importance of developing new agents. This review aims to provide a comprehensive understanding of phytochemicals as inhibitors of PLpro, identify gaps, and ...
Jawaria Jabeen +4 more
openalex +3 more sources
G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease [PDF]
, 2015 G protein-coupled receptor 35 (GPR35) is an orphan receptor, discovered in 1998, that has garnered interest as a potential therapeutic target through its association with a range of diseases.
Amanda E Mackenzie +4 more
core +3 more sources
Reversal of aging-induced increases in aortic stiffness by targeting cytoskeletal protein-protein interfaces [PDF]
, 2018 BACKGROUND: The proximal aorta normally functions as a critical shock absorber that protects small downstream vessels from damage by pressure and flow pulsatility generated by the heart during systole.
Chiu, Joanna +10 more
core +1 more source