Results 11 to 20 of about 3,925 (50)

Role of Protease-Inhibitors in Ocular Diseases

Molecules, 2014
It has been demonstrated that the balance between proteases and protease-inhibitors system plays a key role in maintaining cellular and tissue homeostasis. Indeed, its alteration has been involved in many ocular and systemic diseases.
Nicola Pescosolido, Andrea Barbato, Antonia Pascarella, Rossella Giannotti, Martina Genzano, Marcella Nebbioso   +5 more
doaj   +1 more source

High failure rates of protease inhibitor-based antiretroviral treatment in rural Tanzania - A prospective cohort study.

PLoS ONE, 2020
BACKGROUND:Poor adherence to antiretroviral drugs and viral resistance are the main drivers of treatment failure in HIV-infected patients. In sub-Saharan Africa, avoidance of treatment failure on second-line protease inhibitor therapy is critical as ...
Rahel E Bircher, Alex J Ntamatungiro, Tracy R Glass, Dorcas Mnzava, Amina Nyuri, Herry Mapesi, Daniel H Paris, Manuel Battegay, Thomas Klimkait, Maja Weisser, KIULARCO study group   +10 more
doaj   +1 more source

Reviewing HIV-1 Gag Mutations in Protease Inhibitors Resistance: Insights for Possible Novel Gag Inhibitor Designs

Molecules, 2019
HIV protease inhibitors against the viral protease are often hampered by drug resistance mutations in protease and in the viral substrate Gag. To overcome this drug resistance and inhibit viral maturation, targeting Gag alongside protease rather than ...
Chinh Tran-To Su, Darius Wen-Shuo Koh, Samuel Ken-En Gan   +2 more
doaj   +1 more source

HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat

Retrovirology, 2011
Background Maturation inhibitors are an experimental class of antiretrovirals that inhibit Human Immunodeficiency Virus (HIV) particle maturation, the structural rearrangement required to form infectious virus particles.
Konvalinka Jan, Maas Renée EM, Schipper Pauline J, Pokorná Jana, van Maarseveen Noortje M, Fun Axel, Nijhuis Monique   +6 more
doaj   +1 more source

Preliminary investigations on the serine and aspartic protease inhibitors from Nothopegia beddomei

Ceylon Journal of Science, 2019
Aqueous stem bark extract of Nothopegia beddomei was assayed for serine and aspartic protease inhibitors by using trypsin and pepsin as the target enzymes, respectively. Crude bark extract was dialyzed and subjected to inhibition assays.
M.G.K.P. Dayarathne, Sanath Rajapakse
doaj   +1 more source

Inhibition Profiling of Retroviral Protease Inhibitors Using an HIV-2 Modular System

Viruses, 2015
Retroviral protease inhibitors (PIs) are fundamental pillars in the treatment of HIV infection and acquired immunodeficiency syndrome (AIDS). Currently used PIs are designed against HIV-1, and their effect on HIV-2 is understudied.
Mohamed Mahdi, Zsófia Szojka, János András Mótyán, József Tőzsér   +3 more
doaj   +1 more source

Norovirus Protease Structure and Antivirals Development

Viruses, 2021
Human norovirus (HuNoV) infection is a global health and economic burden. Currently, there are no licensed HuNoV vaccines or antiviral drugs available.
Boyang Zhao, Liya Hu, Yongcheng Song, Ketki Patil, Sasirekha Ramani, Robert L. Atmar, Mary K. Estes, B. V. Venkataram Prasad   +7 more
doaj   +1 more source

A modular system to evaluate the efficacy of protease inhibitors against HIV-2.

PLoS ONE, 2014
The human immunodeficiency virus (HIV) protease is a homodimeric aspartyl protease that is crucial for the viral life-cycle, cleaving proviral polyproteins, hence creating mature protein components that are required for the formation of an infectious ...
Mohamed Mahdi, Krisztina Matúz, Ferenc Tóth, József Tőzsér   +3 more
doaj   +1 more source

Restriction of Viral Glycoprotein Maturation by Cellular Protease Inhibitors

Viruses
The human genome is estimated to encode more than 500 proteases performing a wide range of important physiological functions. They digest proteins in our food, determine the activity of hormones, induce cell death and regulate blood clotting, for example.
Rishikesh Lotke, Moritz Petersen, Daniel Sauter   +2 more
doaj   +1 more source

Structure and Dynamics of Zika Virus Protease and Its Insights into Inhibitor Design

Biomedicines, 2021
Zika virus (ZIKV)—a member of the Flaviviridae family—is an important human pathogen. Its genome encodes a polyprotein that can be further processed into structural and non-structural proteins.
Qingxin Li, Congbao Kang
doaj   +1 more source