Results 11 to 20 of about 695,446 (323)

Combination of Antifungal Drugs and Protease Inhibitors Prevent Candida albicans Biofilm Formation and Disrupt Mature Biofilms

Frontiers in Microbiology, 2020
Biofilms formed by the fungal pathogen Candida albicans are resistant to many of the antifungal agents commonly used in the clinic. Previous reports suggest that protease inhibitors, specifically inhibitors of aspartyl proteases, could be effective ...
Matthew B. Lohse, Matthew B. Lohse, Megha Gulati, Charles S. Craik, Alexander D. Johnson, Clarissa J. Nobile   +5 more
doaj   +1 more source

Phenotypic hypersusceptibility to multiple protease inhibitors and low replicative capacity in patients who are chronically infected with human immunodeficiency virus type 1 [PDF]

, 2005
Increased susceptibility to the protease inhibitors saquinavir and amprenavir has been observed in human immunodeficiency virus type 1 (HIV-1) with specific mutations in protease (V82T and N88S).
Clotet, B, Frost, SDW, Leigh Brown, AJ, Martinez-Picado, J, Parkin, NT, Petropoulos, CJ, Ruiz, L, Wrin, T   +7 more
core   +2 more sources

SjAPI, the first functionally characterized Ascaris-type protease inhibitor from animal venoms. [PDF]

PLoS ONE, 2013
Serine protease inhibitors act as modulators of serine proteases, playing important roles in protecting animal toxin peptides from degradation. However, all known serine protease inhibitors discovered thus far from animal venom belong to the Kunitz-type ...
Zongyun Chen, Bin Wang, Jun Hu, Weishan Yang, Zhijian Cao, Renxi Zhuo, Wenxin Li, Yingliang Wu   +7 more
doaj   +1 more source

Interspecific differences between D. pulex and D. magna in tolerance to cyanobacteria with protease inhibitors. [PDF]

PLoS ONE, 2013
It is known that cyanobacteria negatively affect herbivores due to their production of toxins such as protease inhibitors. In the present study we investigated potential interspecific differences between two major herbivores, Daphnia magna and Daphnia ...
Christian J Kuster, Eric Von Elert
doaj   +1 more source

Structure of protease-cleaved escherichia coliα-2-macroglobulin reveals a putative mechanism of conformational activation for protease entrapment [PDF]

, 2015
Bacterial -2-macroglobulins have been suggested to function in defence as broad-spectrum inhibitors of host proteases that breach the outer membrane.
Burchmore, R.J.S., Byron, O., Cogdell, R.J., Fyfe, C.D., Grinter, R., Josts, I., Mosbahi, K., Roszak, A.W., Walker, D., Wall, D.M.   +9 more
core   +2 more sources

The association between protease inhibitors and anal cancer outcomes in veterans living with HIV treated with definitive chemoradiation: a retrospective study

BMC Cancer, 2021
Background The incidence of anal squamous cell carcinoma has been increasing, particularly in people living with HIV (PLWH). There is concern that radiosensitizing drugs, such as protease inhibitors, commonly used in the management of HIV, may increase ...
Alison K. Yoder, David S. Lakomy, Yongquan Dong, Suchismita Raychaudhury, Kathryn Royse, Christine Hartman, Peter Richardson, Donna L. White, Jennifer R. Kramer, Lilie L. Lin, Elizabeth Chiao   +10 more
doaj   +1 more source

Structural similarities between SARS-CoV2 3CLpro and other viral proteases suggest potential lead molecules for developing broad spectrum antivirals

Frontiers in Chemistry, 2022
Considering the significant impact of the recent COVID-19 outbreak, development of broad-spectrum antivirals is a high priority goal to prevent future global pandemics. Antiviral development processes generally emphasize targeting a specific protein from
Khushboo Bafna, Khushboo Bafna, Christopher L. Cioffi, Robert M. Krug, Gaetano T. Montelione, Gaetano T. Montelione   +5 more
doaj   +1 more source

Role of Protease-Inhibitors in Ocular Diseases

Molecules, 2014
It has been demonstrated that the balance between proteases and protease-inhibitors system plays a key role in maintaining cellular and tissue homeostasis. Indeed, its alteration has been involved in many ocular and systemic diseases.
Nicola Pescosolido, Andrea Barbato, Antonia Pascarella, Rossella Giannotti, Martina Genzano, Marcella Nebbioso   +5 more
doaj   +1 more source

Differences in the Inhibitory Specificity Distinguish the Efficacy of Plant Protease Inhibitors on Mouse Fibrosarcoma

Plants, 2021
Metastasis, the primary cause of death from malignant tumors, is facilitated by multiple protease-mediated processes. Thus, effort has been invested in the development of protease inhibitors to prevent metastasis.
Sonia Yoo Im, Camila Ramalho Bonturi, Adriana Miti Nakahata, Clóvis Ryuichi Nakaie, Arnildo Pott, Vali Joana Pott, Maria Luiza Vilela Oliva   +6 more
doaj   +1 more source

The protease inhibitors

Primary Care Update for OB/GYNS, 2001
With the advent of newer antiretroviral agents for the treatment of patients with human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS), health care providers are faced with many options to optimize their patients' therapy.
College of Medicine, University of Florida, Gainesville, Florida, USA ( host institution ), Tapp Alter, Karen   +1 more
openaire   +3 more sources