Lipometabolic side-effects of three ritonavir-boosted double protease inhibitor regimens without reverse transcriptase inhibitors [PDF]
, 2008 Poster presentation: Purpose of the study To compare the lipometabolic profiles of three double-boosted protease inhibitor (PI) regimens at standard dose, containing saquinavir and ritonavir in combination with lopinavir (LOPSAQ), atazanavir (ATSAQ) or ...
Bickel, Markus +8 more
core +1 more source
Evolutionary Multi-Objective Design of SARS-CoV-2 Protease Inhibitor Candidates
, 2020 Computational drug design based on artificial intelligence is an emerging research area. At the time of writing this paper, the world suffers from an outbreak of the coronavirus SARS-CoV-2.
A Alhossary +24 more
core +1 more source
Osteochondral angiogenesis and increased protease inhibitor expression in OA [PDF]
, 2010 SummaryObjectiveNormal cartilage is resistant to vascular invasion and anti-angiogenic protease inhibitors may contribute to its avascular status. We hypothesized that dysregulated expression of four key anti-angiogenic protease inhibitors may contribute
Fransès, R.E. +3 more
core +2 more sources
Differential in vitro and in vivo effect of barley cysteine and serine protease inhibitors on phytopathogenic microorganisms [PDF]
, 2011 Protease inhibitors from plants have been involved in defence mechanisms against pests and pathogens. Phytocystatins and trypsin/α-amylase inhibitors are two of the best characterized protease inhibitor families in plants.
Cambra Marin, Ines +5 more
core +2 more sources
Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS.
Journal of Medicinal Chemistry, 2016 HIV-1 protease inhibitors continue to play an important role in the treatment of HIV/AIDS, transforming this deadly ailment into a more manageable chronic infection.
Arun K. Ghosh +2 more
semanticscholar +1 more source
The effect of prime-site occupancy on the hepatitis C virus NS3 protease structure. [PDF]
, 2002 We recently reported a new class of inhibitors of the chymotrypsin-like serine protease NS3 of the hepatitis C virus. These inhibitors exploit the binding potential of the S′ site of the protease, which is not generally used by the natural substrates ...
BIANCHI E. +6 more
core +1 more source
Proteolysis and Its Control Using Protease Inhibitors in Fish and Fish Products: A Review.
Comprehensive Reviews in Food Science and Food Safety, 2018 Texture is one of the food quality attributes affecting the consumer's acceptability and the market value. Fish and shellfish undergo weakening or softening of muscle, particularly during extended storage under inappropriate conditions. The phenomenon is
Avtar Singh, S. Benjakul
semanticscholar +1 more source
HIV-1 Protease: Structural Perspectives on Drug Resistance
Viruses, 2009 Antiviral inhibitors of HIV-1 protease are a notable success of structure-based drug design and have dramatically improved AIDS therapy. Analysis of the structures and activities of drug resistant protease variants has revealed novel molecular mechanisms
Irene T. Weber, Johnson Agniswamy
doaj +1 more source
Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017 The current study was designed to assess the inhibitory activity of Broussonetia papyrifera-derived polyphenols against 3-chymotrypsin-like and papain-like coronavirus cysteine proteases. The isolated compounds were broussochalcone B (1), broussochalcone
Ji-Young Park +7 more
semanticscholar +1 more source
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
Science, 2020 Promising antiviral protease inhibitors With no vaccine or proven effective drug against the virus that causes coronavirus disease 2019 (COVID-19), scientists are racing to find clinical antiviral treatments.
Wenhao Dai +26 more
semanticscholar +1 more source