Results 121 to 130 of about 563,257 (338)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Non-Canonical, Extralysosomal Activities of Lysosomal Peptidases in Physiological and Pathological Conditions: New Clinical Opportunities for Cancer Therapy

Cells
Lysosomes are subcellular compartments characterised by an acidic pH, containing an ample variety of acid hydrolases involved in the recycling of biopolymers.
Ryan Conesa-Bakkali, Macarena Morillo-Huesca, Jonathan Martínez-Fábregas   +2 more
doaj   +1 more source

Pathophysiology of enteric infections with Giardia duodenalis

Parasite, 2008
Giardia is the most prevalent human intestinal parasitic protist in the world, and one of the most common parasite of companion animals and young livestock. Giardia is a major cause of diarrhea in children and in travelers.
Buret A.G.
doaj   +1 more source

A Proteolytic Complex Targets Multiple Cell Wall Hydrolases in Pseudomonas aeruginosa

mBio, 2018
Carboxy-terminal processing proteases (CTPs) occur in all three domains of life. In bacteria, some of them have been associated with virulence. However, the precise roles of bacterial CTPs are poorly understood, and few direct proteolytic substrates have
Disha Srivastava, Jin Seo, Binayak Rimal, Sung Joon Kim, Stephanie Zhen, Andrew J. Darwin   +5 more
doaj   +1 more source

Hepatotoxicity Associated with Antiretroviral Therapy Containing Dual versus Single Protease Inhibitors in Individuals Coinfected with Hepatitis C Virus and Human Immunodeficiency Virus [PDF]

, 2002
Curtis Cooper, M. A. Parbhakar, Jonathan B. Angel   +2 more
openalex   +1 more source

Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture

, 2021
Khushboo Bafna, Kris M. White, Balasubramanian Harish, Romel Rosales, Theresa A. Ramelot, Thomas Acton, Elena Moreno, Thomas Kehrer, Lisa Miorin, Catherine A. Royer, Adolfo Garcı́a-Sastre, Robert M. Krug, G.T. Montelione   +12 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Long bugs to short plants – the Lon protease in protein stability and thermotolerance [PDF]

, 2009
Nicolas L. Taylor, A. Harvey Millar
openalex   +1 more source

Activation of SARS-CoV-2 by trypsin-like proteases in the clinical specimens of patients with COVID-19 [PDF]

, 2023
Emiko Yamazaki, Shunsuke Yazawa, Takahisa Shimada, Kosuke Tamura, Yumiko Saga, Masae Itamochi, Noriko Inasaki, Sumiyo Hasegawa, Yoshitomo Morinaga, Kazunori Oishi, Hideki Tani   +10 more
openalex   +1 more source