Results 121 to 130 of about 331,217 (249)

A ubiquitin switch controls autocatalytic inactivation of the DNA–protein crosslink repair protease SPRTN [PDF]

, 2020
Shubo Zhao, Anja Kieser, Hao‐Yi Li, Hannah K. Reinking, Pedro Weickert, Simon Euteneuer, Denitsa Yaneva, Aleida C. Acampora, Maximilian J. Götz, Regina Feederle, Julian Stingele   +10 more
openalex   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Functional Divergence of Two Secreted Immune Proteases of Tomato [PDF]

, 2015
Muhammad Ilyas, Anja C. Hörger, Tolga O. Bozkurt, Harrold A. van den Burg, Farnusch Kaschani, Markus Kaiser, Khaoula Belhaj, Matthew Smoker, M.H.A.J. Joosten, Sophien Kamoun, Renier A. L. van der Hoorn   +10 more
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Type II Transmembrane Serine Protease (TTSP) deregulation in cancer [PDF]

, 2010
L Webb Siobhan
openalex   +1 more source

PAR1 (Protease-Activated Receptor 1) Pepducin Therapy Targeting Myocardial Necrosis in Coronary Artery Disease and Acute Coronary Syndrome Patients Undergoing Cardiac Catheterization [PDF]

, 2020
Athan Kuliopulos, Paul A. Gurbel, Jeffrey J. Rade, Carey Kimmelstiel, Susan E. Turner, Kevin P. Bliden, Elizabeth K. Fletcher, Daniel H. Cox, Lidija Covic   +8 more
openalex   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

Molecular Adaptation of the DegQ Protease to Exert Protein Quality Control in the Bacterial Cell Envelope [PDF]

, 2011
Justyna Sawa‐Makarska, Hélène Malet, T. Krojer, F. Canellas, Michael Ehrmann, Tim Clausen   +5 more
openalex   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source