Results 171 to 180 of about 558,985 (342)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Solution Structure of Substrate-based Ligands When Bound to Hepatitis C Virus NS3 Protease Domain [PDF]

, 1999
Steven R. LaPlante, Dale R. Cameron, Norman Aubry, Sylvain Lefèbvre, George Kukolj, Roger Maurice, Diane Thibeault, Daniel Lamarre, Montse Llinàs‐Brunet   +8 more
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

HIV protease inhibitor-induced cardiac dysfunction and fibrosis is mediated by platelet-derived TGF-β1 and can be suppressed by exogenous carbon monoxide

, 2017
Jeffrey Laurence, Sonia Elhadad, Tyler Robison, Hunter Terry, Rohan Varshney, Sean Woolington, Shahrouz Ghafoory, Mary E. Choi, Jasimuddin Ahamed   +8 more
openalex   +2 more sources

Overproduction of Digestive Enzymes Compensates for Inhibitory Effects of Protease and α-Amylase Inhibitors Fed to Three Species of Leafrollers (Lepidoptera: Tortricidae) [PDF]

, 1998
Ngaire P. Markwick, William A. Laing, John T. Christeller, Jane Z McHenry, M. Newton   +4 more
openalex   +1 more source

Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine

, 2022
Kaitlin R. Hulce, Priyadarshini Jaishankar, Gregory M. Lee, Markus‐Frederik Bohn, Emily J. Connelly, Kristin Wucherer, Chayanid Ongpipattanakul, Regan Volk, Shih‐Wei Chuo, Michelle R. Arkin, Adam R. Renslo, Charles S. Craik   +11 more
openalex   +1 more source

Proteases to die for [PDF]

Genes & Development, 1998
V, Cryns, J, Yuan
openaire   +2 more sources

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

A study on trypsin, Aspergillus flavus and Bacillus sp. protease inhibitory activity in Cassia tora (L.) syn Senna tora (L.) Roxb. seed extract [PDF]

, 2011
Vinayak Ram Tripathi, Shailendra Kumar, Satyendra Kumar Garg   +2 more
openalex   +1 more source