Results 11 to 20 of about 307,734 (314)
, 2020 Plant proteases are involved in most aspects of plant physiology and development, playing key roles in the generation of signaling molecules and as regulators of essential cellular processes such as cell division and metabolism. They take part in important pathways like protein turnover by the degradation of misfolded proteins and the ubiquitin ...
Diaz-Mendoza, M +2 more
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Proteases as therapeutics [PDF]
Biochemical Journal, 2011 Proteases are an expanding class of drugs that hold great promise. The U.S. FDA (Food and Drug Administration) has approved 12 protease therapies, and a number of next generation or completely new proteases are in clinical development. Although they are a well-recognized class of targets for inhibitors, proteases themselves have not typically been ...
Charles S, Craik +2 more
openaire +4 more sources
Proteases in the nervous system [PDF]
, 2022 S.319-371The central nervous system contains numerous proteases fulfilling a plethora of different functions such as activation, regulation and termination of cellular reactions.
Lichtenthaler, S.F. +3 more
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Next-generation nutraceuticals: bioactive peptides from plant proteases [PDF]
, 2022 Bioactive peptides are short and specific fragments of proteins with a wide range of biological activities that provide health benefits to the host. These natural peptides are safe and nontoxic and do not show any side effects.
Anand Nighojkar +5 more
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Matriptase zymogen supports epithelial development, homeostasis and regeneration
BMC Biology, 2017 Background Matriptase is a membrane serine protease essential for epithelial development, homeostasis, and regeneration, as well as a central orchestrator of pathogenic pericellular signaling in the context of inflammatory and proliferative diseases ...
Stine Friis +6 more
doaj +1 more source
Data in Brief, 2016 Thrombosis is a leading cause of death worldwide [1]. Recombinant tissue-type plasminogen activator (tPA) is the FDA-approved thrombolytic drug for ischemic strokes, myocardial infarction and pulmonary embolism.
Lihu Gong +6 more
doaj +1 more source
Family C1 cysteine proteases: Biological diversity or redundancy? [PDF]
, 2003 Recent progress in the identification and partial characterization of novel genes encoding cysteine proteases of the papain family has considerably increased our knowledge of this family of enzymes.
M\ue9nard, Robert +3 more
core +1 more source
Neurobiology of Disease, 2014 Although tissue plasminogen activator (tPA) is known to promote neuronal remodeling in the CNS, no mechanism of how this plastic function takes place has been reported so far.
Sighild Lemarchant +17 more
doaj +1 more source
Malarial proteases and host cell egress: an 'emerging' cascade. [PDF]
, 2008 Malaria is a scourge of large swathes of the globe, stressing the need for a continuing effort to better understand the biology of its aetiological agent. Like all pathogens of the phylum Apicomplexa, the malaria parasite spends part of its life inside a
Blackman, Michael J
core +1 more source
Cell Reports, 2017 Physiologic turnover of interstitial collagen is mediated by a sequential pathway in which collagen is fragmented by pericellular collagenases, endocytosed by collagen receptors, and routed to lysosomes for degradation by cathepsins.
Daniel Hargbøl Madsen +9 more
doaj +1 more source