Results 21 to 30 of about 333,858 (311)
Proteases in the nervous system
, 2022 S.319-371The central nervous system contains numerous proteases fulfilling a plethora of different functions such as activation, regulation and termination of cellular reactions.
Lichtenthaler, S.F. +3 more
core +1 more source
Matriptase zymogen supports epithelial development, homeostasis and regeneration
BMC Biology, 2017 Background Matriptase is a membrane serine protease essential for epithelial development, homeostasis, and regeneration, as well as a central orchestrator of pathogenic pericellular signaling in the context of inflammatory and proliferative diseases ...
Stine Friis +6 more
doaj +1 more source
Data in Brief, 2016 Thrombosis is a leading cause of death worldwide [1]. Recombinant tissue-type plasminogen activator (tPA) is the FDA-approved thrombolytic drug for ischemic strokes, myocardial infarction and pulmonary embolism.
Lihu Gong +6 more
doaj +1 more source
Protease inhibitors targeting the main protease and papain-like protease of coronaviruses [PDF]
Expert Opinion on Therapeutic Patents, 2020 The two cysteine proteases from the coronaviruses, which produced deadly outbreaks in the last two decades, SARS CoV-1/2, and MERS, the main protease (Mpro) and the papain-like protease (PLP) are conserved among the three pathogens and started to be considered as exciting drug targets for developing antivirals.We review the drug design landscape in the
Capasso, Clemente +2 more
openaire +3 more sources
Malarial proteases and host cell egress: an 'emerging' cascade. [PDF]
, 2008 Malaria is a scourge of large swathes of the globe, stressing the need for a continuing effort to better understand the biology of its aetiological agent. Like all pathogens of the phylum Apicomplexa, the malaria parasite spends part of its life inside a
Blackman, Michael J
core +1 more source
Neurobiology of Disease, 2014 Although tissue plasminogen activator (tPA) is known to promote neuronal remodeling in the CNS, no mechanism of how this plastic function takes place has been reported so far.
Sighild Lemarchant +17 more
doaj +1 more source
Family C1 cysteine proteases: Biological diversity or redundancy? [PDF]
, 2003 Recent progress in the identification and partial characterization of novel genes encoding cysteine proteases of the papain family has considerably increased our knowledge of this family of enzymes.
Nägler, D. K. +3 more
core +1 more source
Sustainable Upcycling of Fisheries and Aquaculture Wastes Using Fish-Derived Cold-Adapted Proteases
Frontiers in Nutrition, 2022 The fisheries and aquaculture industries are some of the major economic sectors in the world. However, these industries generate significant amounts of wastes that need to be properly managed to avoid serious health and environmental issues.
Zied Khiari
doaj +1 more source
Identification of proteases employed by dendritic cells in the processing of protein purified derivative (PPD) [PDF]
, 2004 Dendritic cells (DC) are known to present exogenous protein Ag effectively to T cells. In this study we sought to identify the proteases that DC employ during antigen processing.
Mansour Mohamadzadeh +9 more
core +1 more source
Cell Reports, 2017 Physiologic turnover of interstitial collagen is mediated by a sequential pathway in which collagen is fragmented by pericellular collagenases, endocytosed by collagen receptors, and routed to lysosomes for degradation by cathepsins.
Daniel Hargbøl Madsen +9 more
doaj +1 more source