Proteolysis of Extracellular Matrix in Human Disease 2.0. [PDF]
Int J Mol SciYamashita H.
europepmc +1 more source
Unleashing the therapeutic potential of human kallikrein-related serine proteases
Nature reviews. Drug discovery, 2015 I. Prassas +3 more
semanticscholar +1 more source
Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting
Advanced Materials, EarlyView.CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu +4 more
wiley +1 more source
The proteases, amylase and lipase of the pancreas and intestinal contents of germ-free and conventional rats [PDF]
, 1966 Samuel Lepkovsky +4 more
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Protein‐Like Polymers Targeting Keap1/Nrf2 as Therapeutics for Myocardial Infarction
Advanced Materials, EarlyView.We describe a Keap1 targeting protein‐like polymer (PLP) which activates Nrf2, an important cytoprotective transcription factor for relieving myocardial infarction‐induced oxidative stress. This PLP increases cell survival in vitro in multiple relevant cardiac cell types and elicits pro‐reparative responses, improving cardiac function in a preclinical ...
Joshua M. Mesfin +17 more
wiley +1 more source
The Purification and Characterization of a Novel Neutral Protease from <i>Volvariella volvacea</i> Fruiting Bodies and the Enzymatic Digestion of Soybean Isolates. [PDF]
J Fungi (Basel)Xu B +7 more
europepmc +1 more source
Manipulating the Assembly and Architecture of Fibrillar Silk
Advanced Materials, EarlyView.In this study, advanced in situ AFM, PiFM, and Cryo‐EM are leveraged to realize in situ observations of nucleation, growth, and degradation of silk nanofibrils. A clear picture of the assembly and structural evolution of regenerated silk nanofibrils is defined and demonstrates a novel strategy for manipulating their structure and properties, which ...
Chenyang Shi +3 more
wiley +1 more source
Cathepsins in cellular entry of human pathogenic viruses. [PDF]
J VirolPathak T, Pal S, Banerjee I.
europepmc +1 more source
ENZYMIC INACTIVATION OF VACCINIA VIRUS WITH A BACTERIAL PROTEASE
, 1960 Chiaki Nishimura, ISAMU TAGAYA
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