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Decoding substrate recognition in malapain-2 through structural and mutational insights. [PDF]

open access: yesComput Struct Biotechnol J
D'silva S, Lȇ HG, Na BK, Chakraborti S.
europepmc   +1 more source
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Proteases of Acanthamoeba

Parasitology Research, 2023
The members of genus Acanthamoeba are the etiological agent of uncommon but severe or even fatal opportunistic infections in human beings. The presence of different classes of intracellular and extracellular proteases including serine proteases, cysteine proteases, and metalloproteases has been well documented in environmental and clinical isolates of ...
Behroz, Mahdavi Poor   +4 more
openaire   +2 more sources

Proteases, proteases and proteases for presentation

Nature Immunology, 2003
Peptide epitope generation for MHC class I presentation is normally dependent upon proteasome activity. Yet this pathway fails to generate critical HIV epitopes. Instead, the protease TPPII is required for this activity.
Herberts, Carla   +2 more
openaire   +2 more sources

Intestinal proteases

Current Opinion in Gastroenterology, 2023
Purpose of review Proteases constitute a group of enzymes that hydrolyze peptide bonds. Intestinal proteases are an integral part of gut homeostasis and digestion. This review discusses the broader classification of proteases, regulation of proteolytic activity (PA) in the intestinal tract, and how dysregulation of intestinal ...
Sameer, Rao, Madhusudan, Grover
openaire   +2 more sources

Proteases, protease inhibitors and radiation carcinogenesis

International Journal of Radiation Biology, 2021
The purpose of the studies described in this mini review article was to identify nontoxic compounds that could prevent or suppress the radiation induced malignant transformation of cells and be useful as human cancer preventive agents.(1) Many different types of potential anticarcinogenic substances were evaluated initially for their abilities to ...
openaire   +2 more sources

Proteases and protease inhibitors in infectious diseases

Medicinal Research Reviews, 2017
AbstractThere are numerous proteases of pathogenic organisms that are currently targeted for therapeutic intervention along with many that are seen as potential drug targets. This review discusses the chemical and biological makeup of some key druggable proteases expressed by the five major classes of disease causing agents, namely bacteria, viruses ...
Ayodeji A. Agbowuro   +3 more
openaire   +2 more sources

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