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Proteases and protease inhibitors in infectious diseases
Medicinal Research Reviews, 2017AbstractThere are numerous proteases of pathogenic organisms that are currently targeted for therapeutic intervention along with many that are seen as potential drug targets. This review discusses the chemical and biological makeup of some key druggable proteases expressed by the five major classes of disease causing agents, namely bacteria, viruses ...
Ayodeji A. Agbowuro +3 more
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Engineering of proteases and protease inhibition
Current Opinion in Biotechnology, 1991Proteases are unquestionably the single most studied class of enzymes and yet many questions still remain about their mechanisms and roles. Protein engineering offers the opportunity to provide some of the answers. In this review, recent advances towards the understanding of stability, mechanism, specificity and regulation of proteases and their ...
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Proteases and Protease Inhibitors in Tumor Progression
1997Our understanding of the role of matrix degrading proteases in cancer has dramatically expanded over the last two decades. From correlative observations linking proteases to cancer progression, we have accumulated evidence supporting a causal role for proteases in various steps of tumor progression and have become increasingly aware of the complex ...
Y A, DeClerck +5 more
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Periplasmic Proteases and Protease Inhibitors
2014In general, proteases are involved in diverse functions; the most notable include digestive, protective, and regulatory processes. Digestive proteases are involved in protein degradation for nutritional purposes. About 35% of all entries in the MEROPS database are classified as serine proteases.
Nicolette Kucz +2 more
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Seed proteases and protease inhibitors
Economic Botany, 1970This review, which unavoidably has to be of a highly selective nature, covers the literature through December, 1967, and is concerned with two classes of proteins which are involved in the metabolism of seeds: proteases and protease inhibitors. During germination, proteases degrade protein reserves of seeds with an attendant release of peptides, free ...
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Lung Proteases and Protease Inhibitors
1977Homogenates of guinea pig lung show significant protease activity at pH values from 2.2 to 9.9. Perfusion results in increased activity in both acid and alkaline ranges. Protease activity can be extracted by repeated homogenization and sonication of the pellet.
Jeffrey Ihnen, George Kalnitsky
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Inhibition of mite protease (Df-protease) with protease inhibitors.
Biochemistry international, 1993A protease from house dust mite(Dermatophagoides farinae) having high specificity towards a substrate of blood coagulation factor XIIa catalyzes the activation of kallikrein-kinin system in plasma (Takahashi et al., 1990). To prevent the formation of kinin by the mite-protease, inhibition of the protease with its inhibitors was tested in vitro and in ...
A, Matsushima +5 more
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