Results 81 to 90 of about 563,257 (338)

Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]

, 2010
Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Keeble, Anthony H., Mitchell, Daniel A., Schmid, Ralf, Schwaeble, Wilhelm J., Wallis, Russell   +4 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Lighting Conditions Influence the Dynamics of Protease Synthesis and Proteasomal Activity in the White Rot Fungus Cerrena unicolor

Biomolecules, 2020
Recent transcriptomic and biochemical studies have revealed that light influences the global gene expression profile and metabolism of the white-rot fungus Cerrena unicolor.
Anna Pawlik, Magdalena Jaszek, Anita Swatek, Marta Ruminowicz-Stefaniuk, Beata Ciołek, Andrzej Mazur, Grzegorz Janusz   +6 more
doaj   +1 more source

Targeting host cell proteases as a potential treatment strategy to limit the spread of SARS‐CoV‐2 in the respiratory tract

Pharmacology Research & Perspectives, 2021
As the death toll of Coronavirus disease 19 (COVID‐19) continues to rise worldwide, it is imperative to explore novel molecular mechanisms for targeting SARS‐CoV‐2.
Ismail A. El‐Shimy, Mahmoud M. A. Mohamed, Syed Shahzad Hasan, Muhammad A. Hadi   +3 more
doaj   +1 more source

Limited proteolysis in the investigation of beta2-microglobulin amyloidogenic and fibrillar states. [PDF]

, 2005
Amyloid fibrils of patients treated with regular haemodialysis essentially consists of β2-microglobulin (β2-m) and its truncated species ΔN6β2-m lacking six residues at the amino terminus.
AMORESANO, ANGELA, BELLOTTI V, GIORGETTI S, MONTI, MARIA, PUCCI, PIETRO   +4 more
core   +1 more source

Plant Kunitz Inhibitors and Their Interaction with Proteases: Current and Potential Pharmacological Targets [PDF]

, 2022
Camila Ramalho Bonturi, Ana Beatriz da Silva Teixeira, Vitória Morais Rocha, Penélope Ferreira Valente, Juliana Rodrigues Oliveira, Clóvis Macêdo Bezerra Filho, Isabel de Fátima Correia Batista, Maria Luiza Vilela Oliva   +7 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Development and Application of Reversible and Irreversible Covalent Probes for Human and Mouse Cathepsin‐K Activity Detection, Revealing Nuclear Activity

Advanced Science
Cathepsin‐K (CTSK) is an osteoclast‐secreted cysteine protease that efficiently cleaves extracellular matrices and promotes bone homeostasis and remodeling, making it an excellent therapeutic target.
Gourab Dey, Reut Sinai‐Turyansky, Evalyn Yakobovich, Emmanuelle Merquiol, Jure Loboda, Nikhila Sridharan, Yael Houri‐Haddad, David Polak, Simon Yona, Dusan Turk, Ori Wald, Galia Blum   +11 more
doaj   +1 more source

Proteolytic enzyme and inhibitor levels in reindeer (Rangifer tarandus tarandus L.) vs. bovine longissimus muscle, as they relate to ageing rate and response

Rangifer, 1999
Eight reindeer bulls (age 1.5 years) and six Friesian bulls (age 1.5 years) were included in the study for comparison of tenderness. The reindeer were slaughtered at a commercial reindeer slaughter plant in northern Sweden and the Friesian bulls at a ...
V. M.H. Barnier, E. Wiklund, A. van Dijk, F. J.M. Smulders, G. Malmfors   +4 more
doaj   +1 more source

Site-directed mutagenesis of the proposed catalytic amino acids of the Sindbis virus capsid protein autoprotease [PDF]

, 1990
The structural proteins of Sindbis virus are translated as a polyprotein precursor that is cleaved upon translation. The capsid protein is postulated to be a serine protease that releases itself from the N terminus of the nascent polyprotein by ...
Hahn, Chang S., Strauss, James H.
core