Results 101 to 110 of about 204,426 (234)

Proteasome [PDF]

Science-Business eXchange, 2013
  +4 more sources

Precise Mapping of the Proteasome Interaction Region (PIR) of p62/SQSTM1: Decoupling Condensate Formation from Proteasome Recruitment. [PDF]

Cells
Lipskerov F, Cohen-Kaplan V, Ciechanover A.   +2 more
europepmc   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Proteasome [PDF]

Science-Business eXchange, 2009
  +5 more sources

Dual targeting of the UPS and autophagy as a novel therapy for neurodegenerative proteinopathies. [PDF]

Front Cell Neurosci
Lines G, Helley M, Gillotin S, Brownlees J, Duce J, Smethurst P.   +5 more
europepmc   +1 more source

Supplementary File 5 from Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway

Michael P. Ludwig, Matthew D. Galbraith, Neetha Paul Eduthan, Amanda A. Hill, Michael R. Clay, Cristiam Moreno Tellez, Breelyn A. Wilky, Anthony Elias, Joaquı́n M. Espinosa, Kelly D. Sullivan   +9 more
openalex   +1 more source

Antagonistic Ubiquitin Switching by USP7 and RNF40 Orchestrates KDM6A Homeostasis to License Coronavirus Susceptibility

Advanced Science, EarlyView.
We identify an antagonistic ubiquitin circuit that controls cellular permissiveness to multiple coronaviruses. The deubiquitinase USP7 stabilizes the epigenetic regulator KDM6A to upregulate viral receptors, while the E3 ligase RNF40 degrades KDM6A by catalyzing K6/K11‐ubiquitin chains of KDM6A for autophagic degradation.
Meng‐Zhuo Huang, Zhong‐Yuan Yang, Shi Wang, Yan Ge, Lan Lin, Mia Madel Alfajaro, Renata B. Filler, Wan‐Yao Song, Ming‐Zhu Kong, Jin Wei   +9 more
wiley   +1 more source

Structures of the 26<i>S</i> proteasome in complex with the Hsp70 co-chaperone Bag1 reveal a mechanism for direct substrate transfer. [PDF]

Sci Adv
Maestro-López M, Cheng TC, Muntaner J, Menéndez M, Alonso M, Schweitzer A, Ishizaka M, Tomko RJ, Cuéllar J, Valpuesta JM, Sakata E.   +10 more
europepmc   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Multilayer modulation of the proteasome: new strategies for neuroprotection. [PDF]

Front Mol Neurosci
Sokolov M, Taniguchi H, Weber JJ.
europepmc   +1 more source