Results 191 to 200 of about 393,592 (390)

Combining PIM‐2 and PARP1 Inhibitors Induces MICA Expression on Multiple Myeloma Cells to Activate NK Cells through NKG2D Binding

Advanced Science, EarlyView.
The findings suggest that the combination of PIM‐2 and PARP1 inhibitors can induce MICA expression on MM cells, thereby activating NK cells through NKG2D binding. This process may restore NK cell function and serve as a potential therapeutic approach for MM patients. Abstract While immunogenic death in tumor cells activates specific anti‐tumor T cells,
Zhaoyun Liu, Wenhui Lei, Xiaohan Liu, Hui Liu, Kai Ding, Jia Song, Rong Fu   +6 more
wiley   +1 more source

The cleavage preference of the proteasome governs the yield of antigenic peptides. [PDF]

, 1995
Maren Eggers, Bettina Boes-Fabian, Thomas Ruppert, Peter M. Kloetzel, Ulrich H. Koszinowski   +4 more
openalex   +1 more source

β‐catenin is a target for the ubiquitin–proteasome pathway

, 1997
H. Aberle, A. Bauer, J. Stappert, A. Kispert, R. Kemler   +4 more
semanticscholar   +1 more source

TRIM21‐Mediated K11‐Linked Ubiquitination of ID1 Suppresses Tumorigenesis and Promotes Cuproptosis in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
ID1 is regulated by E3 ligase TRIM21, which adds non‐degradative K11‐linked ubiquitin at Lys91, disrupting ID1‐TCF12 binding and freeing TCF12 to upregulate copper transporter SLC31A1. Enhanced SLC31A1 elevates intracellular copper, triggers cuproptosis, and inhibits ESCC growth.
Lei Li, Yuqing Wang, Ruoxi Tian, Tianshuo Yang, Yaxin Liu, Baoen Shan, Lianmei Zhao   +6 more
wiley   +1 more source

Deoxyribonucleic acid vaccines encoding antigens with rapid proteasome-dependent degradation are highly efficient inducers of cytolytic T lymphocytes. [PDF]

, 1997
Yunqi Wu, Thomas J. Kipps
openalex   +1 more source

The ubiquitin–proteasome-system [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2014
Sommer, T., Wolf, D.H.
openaire   +3 more sources

Small Extracellular Vesicles Orchestrate Cisplatin‐Induced Ototoxicity: Potential Biomarker and Targets Discovery

Advanced Science, EarlyView.
Cisplatin causes reactive oxygen species accumulation, leading to apoptosis and inflammation in cochlear hair cells. Small extracellular vesicles primarily derived from the damaged hair cells likely contribute to cisplatin‐induced ototoxicity, carrying a variety of microRNAs and proteins.
Jingru Ai, Shasha Zhang, Mingchen Dai, Pei Jiang, Jingyuan Huang, Hairong Xiao, Yanqin Lin, Xujun Tang, Wei Tong, Jun He, Qiuyue Mao, Yintao Wang, Zixuan Ye, Tian Wang, Renjie Chai   +14 more
wiley   +1 more source

Dissecting the assembly pathway of the 20S proteasome [PDF]

, 1997
Frank Zühl, Erika Seemüller, Ralph Golbik, Wolfgang Baumeister   +3 more
openalex   +1 more source

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Advanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai   +9 more
wiley   +1 more source

Proteasome and Antigen Processing.

, 1992
Tomohiro Tamura, Keiji Tanaka, Akira Ichikawa   +2 more
openalex   +2 more sources