Results 191 to 200 of about 355,945 (323)

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source

Proteasomes raise the microtubule dynamics in influenza A (H1N1) virus-infected LLC-MK2 cells

, 2015
Flora De Conto, Carlo Chezzi, Alessandra Fazzi, Sergey V. Razin, Maria Cristina Arcangeletti, Maria Cristina Medici, Rita Gatti, Adriana Calderaro   +7 more
openalex   +1 more source

Targeting the CMKLR1‐Mediated Signaling Rebalances Immunometabolism State in Middle‐Age Testicular Macrophages

Advanced Science, EarlyView.
In middle age, testicular CMKLR1⁺ macrophages exhibited a pro‐inflammatory immunometabolic profile, mediated by adipose signals associated with high BMI. However, inhibition of CMKLR1 signaling, either through Cmklr1 genetic ablation or treatment with a CMKLR1 antagonist peptide, can reverse this phenotype.
Zhendong Zhu, Feifei Du, Yang Liu, Jinchunzi Yang, Lei Ge, Tianxia Xiao, Mengxia Li, Jie Chen, Jia Tang, Yali Yang, Jian V. Zhang   +10 more
wiley   +1 more source

Transmission of Non-Constitutive Proteasomes Between Cells via Extracellular Vesicles. [PDF]

Int J Mol Sci
Grigorieva EV, Burov AV, Starodubova ES, Lebedev TD, Rezvykh AP, Belogurov AA, Spirin PV, Prassolov VS, Karpov VL, Morozov AV.   +9 more
europepmc   +1 more source

NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement

Advanced Science, EarlyView.
This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang, Zemin Jiang, Qiaoyun Yang, Hong Zheng, Minghao Wang, Chennianci Zhu, Lih‐Wen Deng, Karen Carmelina Crasta, Yih‐Cherng Liou   +8 more
wiley   +1 more source

The Interplay Between the Ubiquitin-Proteasome System and Oxidative Stress: A Future Perspective in Eye Diseases. [PDF]

Antioxidants (Basel)
Tundo GR, Zingale GA, Pandino I, Peroni E, Sbardella D, Bocedi A.   +5 more
europepmc   +1 more source

THE EXPRESSION OF THE PROTEASOME EACH SUBUNIT IN HUMAN ATHEROSCLEROTIC PLAQUE [PDF]

, 2012
Chunling Wang, Wang Mingxiao, Jia Wang, Chunling Wang   +3 more
openalex   +1 more source

Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer

, 2021
Ratika Kunder, Michelle Velyunskiy, Sara F. Dunne, Byoung-Kyu Cho, Deepak Kanojia, Lauren R. Begg, Adrienne Orriols, Erica Fleming-Trujillo, Pranathi Vadlamani, A. Vialichka, Rosemary Bolin, Jessica N Perrino, Diane J. Roth, Matthew R. Clutter, Nicolette A Zielinski-Mozny, Young Ah Goo, Massimo Cristofanilli, Marc L. Mendillo, Athanassios Vassilopoulos, Dai Horiuchi   +19 more
openalex   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Halorotetin B, A Novel Terpenoid Compound Derived from Marine Ascidian, Suppresses Tumor Growth by Targeting the Cell Cycle Regulator UBE2C

Advanced Science, EarlyView.
Halorotetin B, a novel small‐molecule terpenoid identified from an edible marine ascidian, exhibits strong anti‐tumor activity both in vitro and in vivo through direct targeting UBE2C to induce tumor cell cycle arrest and then lead tumor cell senescence. As a newly discovered UBE2C inhibitor, Halorotetin B can serve as a novel potential cell senescence
Shanhao Han, Jianhui Li, Yuting Zhu, Penghui Liu, Yaoyao Zheng, Muchun He, Bo Dong   +6 more
wiley   +1 more source