Results 211 to 220 of about 411,261 (379)

Role of proteasomes in transcription and their regulation by covalent modifications [PDF]

, 2008
Mittenberg Ag
openalex   +1 more source

Recognition and processing of ubiquitin-protein conjugates by the proteasome.

Annual Review of Biochemistry, 2009
D. Finley
semanticscholar   +1 more source

CSN6 Promotes Pancreatic Cancer Progression and Gemcitabine Resistance via Antagonizing DCAF1‐Mediated Ubiquitination of NPM1

Advanced Science, EarlyView.
COP9 signalosome subunit 6 (CSN6) promotes the auto‐ubiquitination and degradation of DDB1‐CUL4 associated factor 1 (DCAF1), thereby antagonizing DCAF1‐mediated ubiquitination of Nucleophosmin (NPM1). This stabilization of NPM1 enhances the ribosome biogenesis process and the translation of specific gemcitabine‐resistance proteins, ultimately driving ...
Yijing Zhang, Han Gao, Aiwen Tang, Haiwen Lyu, Zongmin Fan, Jiahui Guo, Yuzhi Wang, Hairong Yi, Qihao Pan, Haidan Luo, Baifu Qin, Boyu Zhang, Xiangqi Meng, Qingxin Liu, Mong‐Hong Lee   +14 more
wiley   +1 more source

Salt Stress–Induced Disassembly of Arabidopsis Cortical Microtubule Arrays Involves 26S Proteasome–Dependent Degradation of SPIRAL1  

, 2011
Songhu Wang, Jasmina Kurepa, Takashi Hashimoto, Jan Smalle   +3 more
openalex   +2 more sources

Activation of Atypical Protein Kinase C ζ by Caspase Processing and Degradation by the Ubiquitin-Proteasome System [PDF]

, 2000
Lucinda Smith, Lei Chen, Mary E. Reyland, Tracie A. DeVries, Robert V. Talanian, Satoshi Ōmura, Jeffrey B. Smith   +6 more
openalex   +1 more source

Ubc9‐Mediated SUMOylation of RPL3, an Unappreciated Mechanism against Hepatocyte Senescence by Repressing the DHX9‐p16 Axis

Advanced Science, EarlyView.
Liver aging is characterized by a decline in the expression of the SUMO‐conjugating enzyme Ubc9, resulting in reduced SUMOylation levels in hepatocytes, particularly in the case of ribosomal protein RPL3. Disruption of RPL3 SUMOylation increases its nuclear translocation. Interestingly, ribosome‐free RPL3 facilitates the recruitment of helicase DHX9 to
Hao Xie, Zhichao Gao, Xin Liu, Shiyi Zhang, Yuhan Wang, Jia Gao, Ping Qi, Lu Zhang, Jiawei Zhao, Tian Xiong, Teng Huang, Jia Song, Qilin Yu, Shu Zhang, Yanjun Liu, Ping Yang, Maryam S. Al‐Motawa, Quan Gong, Junfeng Dong, Hao Yin, Fei Sun, Shiwei Liu, Cong‐Yi Wang   +22 more
wiley   +1 more source

Proteasome: Role in T Cell Function Regulation. [PDF]

Int J Biol Sci
Tang D, Wu X, Lei JH, Qiao Y, Deng CX.
europepmc   +1 more source

The Ubiquitin-Proteasome System as a Prospective Molecular Target for Cancer Treatment and Prevention

, 2010
Di Chen, Q. Ping Dou
openalex   +2 more sources

Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease

Advanced Science, EarlyView.
Higher serum UA levels are associated with reduced AD risk in epidemiological studies. UA enhances microglial phagocytic capacity primarily by restoring CD36 and TREM2 receptor recycling that is impaired by Aβ exposure. Therapeutically, UA supplementation improves cognitive function and reduces neuropathology in AD mouse model by enhancing microglial ...
De Xie, Qiuyang Zheng, Jiaming Lv, Qian Zhang, Zhiwei Cui, Shuai Huang, Wei Yu, Binyang Chen, Wanling Que, Shanpan Fu, Yuemei Xi, Jiayu Chen, Xueling Ye, Shuyi Chen, Hairong Zhao, Tetsuya Yamamoto, Hidenori Koyama, Xin Wang, Jidong Cheng   +18 more
wiley   +1 more source

In-situ cross-linking mass spectrometry reveals compartment-specific proteasomal interactions and structural heterogeneity. [PDF]

Nat Commun
Zhao L, Zhao R, Gong Z, Liang F, Zhao N, Zhong B, Liu M, Zhang Y, Zhao Q, Zhang L, Tang C.   +10 more
europepmc   +1 more source