Results 211 to 220 of about 393,592 (390)

Novel dipeptide aldehydes are proteasome inhibitors and block the MHC-I antigen-processing pathway. [PDF]

, 1995
Clifford V. Harding, J. France, Rui Song, John M. Farah, Sankar Chatterjee, M. Iqbal, Robert Siman   +6 more
openalex   +1 more source

PIM1 Attenuates Innate Immunity to Foster Coronavirus Replication through Ubiquitin Ligase β‐TrCP‐Mediated IFNAR1 Degradation

Advanced Science, EarlyView.
Hijacking Host Kinase PIM1: A β‐Coronavirus (OC43) strategy to degrade IFNAR1 and evade antiviral immunity. Human β‐coronaviruses (OC43) exploit the proto‐oncoprotein PIM1 kinase to sabotage innate immunity. Viral RNA/proteins upregulate PIM1, which phosphorylates E3 ligase β‐TrCP1.
Qianya Wan, Lin Zhu, Cien Chen, Li Zhong, Houying Leung, Wei Li, Chang Xu, Xi Yao, Huan Hu, Mandi Wu, Yuxin Hou, Hin Chu, Yiran Wang, Sheng Chen, Mingyu Pan, Zongwei Cai, Ming‐liang He   +16 more
wiley   +1 more source

Heterogeneous protein dynamics links to mitochondrial activity, glucose transporter, and ALDH cancer stem cell properties. [PDF]

BMC Cancer
Krkoška M, Tylichová Z, Zatloukalová P, Müller P, Vojtěšek B, Coates PJ.   +5 more
europepmc   +1 more source

NOD Mice Are Defective in Proteasome Production and Activation of NF-κB

, 1999
Takuma Hayashi, Denise L. Faustman
openalex   +1 more source

Characterization of the Proteasome Regulator PA28 [PDF]

, 1996
Kwangseog Ahn, Mark G. Erlander, Didier Leturcq, Per A. Peterson, Klaus Früh, Young Mok Yang   +5 more
openalex   +1 more source

Phytophthora Disrupts Plant Immunity by Manipulating Nitric Oxide Homeostasis Through GSNOR Inhibition

Advanced Science, EarlyView.
Phytophthora capsici effector PcRD18 targets tomato GSNOR to disrupt NO homeostasis, promoting S‐nitrosylation of immune proteins like RBOHD. This suppresses ROS bursts and promotes pathogen infection. Mutation of the PcRD18‐binding sites of GSNOR avoids pathogen manipulation and offers a strategy to enhance crop resistance. Abstract Nitric oxide (NO),
Tingting Li, Jing Kang, Haizhu Zhang, Lina Wang, Minghui Lu, Lin Cai, Jianming Li, Matthieu H. A. J. Joosten, Yu Du   +8 more
wiley   +1 more source

Nuclear p62/SQSTM1 facilitates ubiquitin-independent proteasomal degradation of BMAL1. [PDF]

PLoS Genet
Zhang C, Wu Q, Zhang H, Liu R, Li L.
europepmc   +1 more source

Linkage of TATA-Binding Protein and Proteasome Subunit C5 Genes in Mice and Humans Reveals Synteny Conserved between Mammals and Invertebrates

, 1997
Zdeněk Trachtulec, Renata M. J. Hamvas, Jiřı́ Forejt, Hans Lehrach, Vladimir Vincek, Jan Klein   +5 more
openalex   +1 more source

Molecular cloning of the mouse proteasome subunits MC14 and MECL‐1: reciprocally regulated tissue expression of interferon‐γ‐modulated proteasome subunits [PDF]

, 1997
Ralf Stohwasser, Sybille Standera, Inga Peters, Peter‐M. Kloetzel, Marcus Groettrup   +4 more
openalex   +1 more source

Ezetimibe Engineered L14‐8 Suppresses Advanced Prostate Cancer by Activating PLK1/TP53‐SAT1‐Induced Ferroptosis

Advanced Science, EarlyView.
L14‐8, a small molecule derived from the marketed drug ezetimibe, potently inhibits advanced prostate cancer independent of androgen receptor signaling. L14‐8 binds PLK1, triggering its ubiquitin‐mediated degradation. This activates TP53‐dependent transcription of SAT1, inducing ferroptosis and suppressing tumor growth in prostate cancer patient ...
Yu Zhang, Xiao‐wen Song, Na Zhang, Xue‐hui Li, Fan‐chen Wu, Yu‐ang Wei, Dong‐liang Xu, Ling‐fan Xu, Fu‐wen Yuan   +8 more
wiley   +1 more source