Results 221 to 230 of about 355,945 (323)

Targeted Protein Degradation (TPD) for Immunotherapy: Understanding Proteolysis Targeting Chimera-Driven Ubiquitin-Proteasome Interactions [PDF]

Rajamanikkam Kamaraj, Subhrojyoti Ghosh, Souvadra Das, Shinjini Sen, Priyanka Kumar, Madhurima Majumdar, R. Dasgupta, Sampurna Mukherjee, Shrimanti Das, Indrilla Ghose, Petr Pávek, Muruga Poopathi Raja Karuppiah, Anil A. Chuturgoon, Krishnan Anand   +13 more
openalex   +1 more source

USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer

Advanced Science, EarlyView.
USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen, Ling Wang, Hongmei Fan, Lisheng Li, Lingyu Zhang, Ruoxin Li, Fang Liu, Fuli Wen, Yunbin Ye, Chuanzhong Huang   +9 more
wiley   +1 more source

Proteasome [PDF]

Science-Business eXchange, 2012
openaire   +2 more sources

Chimeric degraders in neurodegenerative diseases: Challenges and future directions. [PDF]

J Transl Int Med
Zheng H, Cui K, Mao J, Wan Y, Zheng J.
europepmc   +1 more source

Figure S1 from HDAC6 Inhibition Releases HR23B to Activate Proteasomes, Expand the Tumor Immunopeptidome and Amplify T-cell Antimyeloma Activity

Priyanka S. Rana, James J. Ignatz-Hoover, Byung‐Gyu Kim, Ehsan Malek, Yuriy Federov, Drew Adams, Timothy A. Chan, James J. Driscoll   +7 more
openalex   +1 more source

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

Advanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li, Xueqi He, Xinyuan Hao, Yu Zhang, Xin Zhao, Shuang Wang, Zhenru Wang, Haonan Du, Hongda Li, Lian Yi, Zhimin Du, Weijie Du   +11 more
wiley   +1 more source

Nitric Oxide and Interleukin-1β Stimulate the Proteasome-Independent Degradation of the Retinoic Acid Hydroxylase CYP2C22 in Primary Rat Hepatocytes

, 2013
Choon-myung Lee, Bang-sub Lee, Samuel L.M. Arnold, Nina Isoherranen, Edward T. Morgan   +4 more
openalex   +1 more source

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

Targeting OsRING80 enables resistance to rice blast without developmental costs. [PDF]

Plant Physiol
Teixeira M.
europepmc   +1 more source

Identification of Potent and Selective Non-covalent Inhibitors of the Plasmodium falciparum Proteasome [PDF]

, 2014
Hao Li, Christopher Tsu, Christopher Blackburn, Gang Li, Paul Hales, Lawrence R. Dick, Matthew Bogyo   +6 more
openalex   +1 more source