Results 221 to 230 of about 411,261 (379)

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Proteasome inhibition as a potential therapeutic target in thymic cancer. [PDF]

Cell Death Dis
Okada S, Benter L, Schrell L, Müller D, Selcen S, Bohnenberger H, Schneider C, Schneider G, Lohrberg M, Koch R, Overbeck TR, von Hammerstein-Equord A, Welter S, Hinterthaner M, Cordes L, Shirneshan K, Netzer C, Inoue M, Marx A, Ströbel P, Küffer S.   +20 more
europepmc   +1 more source

Evidence that the Ubiquitin Proteasome System Plays a Prominent Role in Inflammatory Bowel Disease: Possible Pharmacological Approaches [PDF]

, 2016
Leo R. Fitzpatrick
openalex   +1 more source

Measurement of ex vivo resistance to proteasome inhibitors, IMiDs, and daratumumab during multiple myeloma progression [PDF]

, 2020
Zachary J. Walker, Michael J. VanWyngarden, Brett M. Stevens, Diana Abbott, Andrew Hammes, Christophe Langouët-Astrié, Clayton A. Smith, Brent E. Palmer, Peter A. Forsberg, Tomer M. Mark, Craig T. Jordan, Daniel W. Sherbenou   +11 more
openalex   +1 more source

Dysregulation of CircZNF79(5) Modulates YBX1 Stability and Selective Autophagy to Drive Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
In HCC, circZNF79(5) binds to YBX1 and functions as an oncogene, recruits BRCC36 to remove K63‐linked ubiquitin chains to stabilize YBX1 protein, and promotes HCC progression via the HIF‐1 signaling pathway. Conversely, circZNF79(5) silencing activates the AMPK/mTOR pathway, inducing p62‐mediated selective autophagic degradation of YBX1.
Xueqiang Guo, Lingling Xi, Yukun Liu, Wenbao Lv, Tianzi Li, Andong Ju, Zhenlin Fan, Yaping Shen, Zhuang Qian, Weiyun Wang, Zhuo Liang, Wenjuan Song, Kaiwen Chang, Shuangping Ma, Junhe Zhang, Tao Han, Kun You, Cunshuan Xu, Lei Wang, Weisheng Guo, Wenjie Ren   +20 more
wiley   +1 more source

Targeting the proteasome subunit PSMB5 by RNA interference induces proteasome dysfunction and mortality in the Colorado potato beetle (Leptinotarsa decemlineata). [PDF]

Sci Rep
Graser L, Gordon ER, Jamison M, Talton W, Chen Y, Knorr E, Windfelder A, Narva K, Vilcinskas A.   +8 more
europepmc   +1 more source

Status and role of the ubiquitin–proteasome system in renal fibrosis

Yizhen Chen, Rong Dai, Meng Cheng, Weili Wang, Chuanjiao Liu, Zeping Cao, Yong Ge, Yiping Wang, Lei Zhang   +8 more
openalex   +1 more source

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

Inhibitors of the 20S proteasome β5 subunit as potent and selective agents against <i>Trichomonas vaginalis</i>. [PDF]

Antimicrob Agents Chemother
Miyamoto Y, Hurysz BM, Fajtova P, Eckmann P, Serafim MSM, Kronenberger T, Al-Hindy M, Dekker PM, Maurits E, Overkleeft HS, Bergdahl BM, Almaliti J, Gerwick WH, O'Donoghue AJ, Eckmann L.   +14 more
europepmc   +1 more source

Single‐Cell Insights Into Macrophage Subtypes in Pulmonary Infections

Advanced Science, EarlyView.
This review highlights the dynamic plasticity of macrophages during pulmonary infections and proposes an integrative framework defining six functional subtypes: Inflam‐Ms, Hub‐Ms, Reg‐Ms, Prolif‐Ms, Memory‐Ms, and Senesc‐Ms. Single‐cell omics delineate their distinct roles in homeostasis and infection, refining our understanding of macrophage ...
Zhaoheng Lin, Yuxiao Zheng, Yu Zhong, Hongyan Wang   +3 more
wiley   +1 more source