Results 231 to 240 of about 355,945 (323)

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Proteasome: Role in T Cell Function Regulation. [PDF]

Int J Biol Sci
Tang D, Wu X, Lei JH, Qiao Y, Deng CX.
europepmc   +1 more source

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

Beyond degradation tags: How FAT10 and ubiquitin shape substrate energy landscapes. [PDF]

Essays Biochem
Ravichandran A, Sivakumar A, Das R.
europepmc   +1 more source

Functional characterization of pathway inhibitors for the ubiquitin-proteasome system (UPS) as tool compounds for CRBN and VHL-mediated targeted protein degradation [PDF]

Martin P. Schwalm, Amelie Menge, Lewis Elson, Francesco Greco, Matthew B. Robers, Susanne Müller, Stefan Knapp   +6 more
openalex   +1 more source

A Reactive Antagonist Strategy: Cysteine‐Directed Covalent Molecular Glue in Plant Hormone Receptor Regulation

Advanced Science, EarlyView.
The plant hormone jasmonate is perceived by COI1‐JAZ co‐receptors comprising a single F‐box protein COI1 and multiple JAZ repressors with overlapping functions, complicating genetic analysis. We present a reactive antagonist (RA) strategy that selectively promotes COI1 binding to a cysteine‐engineered JAZ variant while blocking wild‐type JAZs, enabling
Minoru Ueda, Kotaro Matsumoto, Takao Nomura, Yousuke Takaoka, Taichi Okumura, Wataru Kozaki, Hikaru Hoshikawa, Yuho Nishizato, Andrea Chini, Roberto Solano, Katsumi Maenaka   +10 more
wiley   +1 more source

The ubiquitin-proteasome system in Alzheimer's disease: mechanism of action and current status of treatment. [PDF]

Front Aging Neurosci
Jia S, Li Q, Rui X, Qin W, Zhang W, Dou J, Zhang X.   +6 more
europepmc   +1 more source

Thermally Gated Dual‐Cascade Nanozyme for Enhanced Mild‐Temperature Photothermal Therapy

Advanced Science, EarlyView.
A thermo‐responsive cascade nanozyme (Ru‐GOx‐PNN) synergistically enhances mild photothermal therapy by dual suppression of HSP70 through ROS‐induced lipid peroxidation and ATP depletion. This intelligent system effectively overcomes thermotolerance and amplifies apoptosis, offering a safe and precise strategy for tumor treatment.
Shuyu Wang, Shenghui Wang, Mengyuan Cao, Lulu Wang, Wei Jiang, Xiyun Yan, Ying Liu, Bing Jiang   +7 more
wiley   +1 more source

Targeting the ubiquitin-proteasome system and drug therapy in colorectal cancer. [PDF]

J Mol Cell Biol
Su R, Shao Y, Wang Q, Liu D, Wang Y, Kong D, Qiu Y.   +6 more
europepmc   +1 more source

P0696 : Proteasome subunit alpha type-6 regulates the expression of proviral host genes in hepatitis C virus infection

, 2015
Ruth Broering, Martin Trippler, M. Lutterbeck, C.I. Real, Dominik A. Megger, Thilo Bracht, Vincent Schweinsberg, Barbara Sitek, Martin Eisenacher, Helmut E. Meyer, Hideo A. Baba, Frank Weber, Andreas-Claudius Hoffmann, Guido Gerken, JF Schlaak   +14 more
openalex   +1 more source