Results 31 to 40 of about 393,592 (390)

Prions and the proteasome

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2008
Prion diseases are fatal neurodegenerative disorders that include Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy in animals. They are unique in terms of their biology because they are caused by the conformational re-arrangement of a normal host-encoded prion protein, PrPC, to an abnormal infectious isoform, PrPSc.
Deriziotis, P., Tabrizi, S.
openaire   +4 more sources

Selective vulnerability of neurons to acute toxicity after proteasome inhibitor treatment: Implications for oxidative stress and insolubility of newly synthesized proteins [PDF]

, 2010
Maintaining protein homeostasis is vital to cell viability, with numerous studies demonstrating a role for proteasome inhibition occurring during the aging of a variety of tissues and, presumably, contributing to the disruption of cellular homeostasis ...
Dasuri, Kalavathi, Di Blasio, Alessia, Ebenezer, Philip J., Fernandez Kim, Sun Ok, Gavilán, Elena, Keller, Jeffrey N., Uranga, Romina Maria, Zhang, Le   +7 more
core   +1 more source

The capture proteasome assay (CAPA) to evaluate subtype-specific proteasome inhibitors

Data in Brief, 2015
We recently developed a new assay to measure proteasome activity in vitro (CAPA for capture proteasome assay) [1], based on proteasome capture on an antibody-coated plate.
Nathalie Vigneron, Joanna Abi Habib, Benoît J. Van den Eynde   +2 more
doaj   +1 more source

Synaptic proteasome is inhibited in Alzheimer’s disease models and associates with memory impairment in mice

Communications Biology, 2023
The proteasome plays key roles in synaptic plasticity and memory by regulating protein turnover, quality control, and elimination of oxidized/misfolded proteins. Here, we investigate proteasome function and localization at synapses in Alzheimer’s disease
Felipe C. Ribeiro, Danielle Cozachenco, Luana Heimfarth, Juliana T. S. Fortuna, Guilherme B. de Freitas, Jorge M. de Sousa, Soniza V. Alves-Leon, Renata E. P. Leite, Claudia K. Suemoto, Lea T. Grinberg, Fernanda G. De Felice, Mychael V. Lourenco, Sergio T. Ferreira   +12 more
doaj   +1 more source

Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity [PDF]

, 2014
During macroautophagy, conjugation of ATG12 to ATG5 is essential for LC3 lipidation and autophagosome formation. Additionally, ATG12 has ATG5-independent functions in diverse processes including mitochondrial fusion and mitochondrial-dependent apoptosis.
Debnath, Jayanta, Giampazolias, Evangelos, Green, Douglas R., Haller, Martina, Hock, Andreas K., Oberst, Andrew, Ryan, Kevin M., Tait, Stephen W. G., Vousden, Karen H.   +8 more
core   +4 more sources

Subnormothermic Perfusion in the Isolated Rat Liver Preserves the Antioxidant Glutathione and Enhances the Function of the Ubiquitin Proteasome System. [PDF]

, 2016
The reduction of oxidative stress is suggested to be one of the main mechanisms to explain the benefits of subnormothermic perfusion against ischemic liver damage. In this study we investigated the early cellular mechanisms induced in isolated rat livers
Alva, Norma, Carbonell, Teresa, Dewey, Shannamar, Gomes, Aldrin V, Sanchez-Nuño, Sergio   +4 more
core   +9 more sources

Dss1 is a 26S proteasome ubiquitin receptor [PDF]

, 2014
The ubiquitin-proteasome system is the major pathway for protein degradation in eukaryotic cells. Proteins to be degraded are conjugated to ubiquitin chains that act as recognition signals for the 26S proteasome.
Arrigoni, Bohn, Choi, Cornilescu, Deveraux, Dosztányi, Ellisdon, Faza, Finley, Funakoshi, Groll, Hartmann-Petersen, Husnjak, Husnjak, Jossé, Kjaergaard, Kriegenburg, Matsuyama, Mayor, Moreno, Obradovic, Peth, Saeki, Sakata, Schreiner, Seeger, Sone, Spratt, Su, Tomko, Uversky, Verma, Verma, Vogt, Wilkinson, Yang   +35 more
core   +4 more sources

Visualizing Proteasome Activity and Intracellular Localization Using Fluorescent Proteins and Activity-Based Probes

Frontiers in Molecular Biosciences, 2019
The proteasome is a multi-catalytic molecular machine that plays a key role in the degradation of many cytoplasmic and nuclear proteins. The proteasome is essential and proteasome malfunction is associated with various disease pathologies.
Sabine Schipper-Krom, Alicia Sanz Sanz, Emma J. van Bodegraven, Dave Speijer, Bogdan I. Florea, Huib Ovaa, Eric A. Reits   +6 more
doaj   +1 more source

A Practical Review of Proteasome Pharmacology

Pharmacological Reviews, 2019
The ubiquitin proteasome system (UPS) degrades individual proteins in a highly regulated fashion and is responsible for the degradation of misfolded, damaged, or unneeded cellular proteins.
Tiffany A Thibaudeau, David M. Smith
semanticscholar   +1 more source

A Conditional Yeast E1 Mutant Blocks the Ubiquitin–Proteasome Pathway and Reveals a Role for Ubiquitin Conjugates in Targeting Rad23 to the Proteasome [PDF]

, 2007
E1 ubiquitin activating enzyme catalyzes the initial step in all ubiquitin-dependent processes. We report the isolation of uba1-204, a temperature-sensitive allele of the essential Saccharomyces cerevisiae E1 gene, UBA1.
Amerik A. Y., Babbitt S. E., Bertolaet B. L., Bertolaet B. L., Biggins S., Chen L., Cheng I. H., Ciechanover A., Deshaies R. J., Deveraux Q., Elsasser S., Elsasser S., Elsasser S., Finley D., Funakoshi M., Gandre S., Glickman M. H., Guthrie C., Haas A. L., Haracska L., Hicke L., Hofmann K., Johnson E. S., Kang Y., Kleijnen M. F., Kulka R. G., Lambertson D., Lambertson D., Lowe E. D., Madura K., McGrath J. P., Nazli Ghaboosi, Ortolan T. G., Peng J., Pickart C. M., Raasi S., Raasi S., Rao H., Raymond J. Deshaies, Richly H., Ryu K. S., Saeki Y., Saeki Y., Saeki Y., Salvat C., Schauber C., Schuberth C., Shimada K., Swanson R., Swanson R., van Nocker S., van Nocker S., Verma R., Verma R., Verma R., Walters K. J., Walters K. J., Watkins J. F., Wilkinson C.R.M., William Tansey   +59 more
core   +2 more sources