Results 31 to 40 of about 204,769 (294)
Role of amino acid metabolism in mitochondrial homeostasis
Frontiers in Cell and Developmental Biology, 2023 Mitochondria are central hubs for energy production, metabolism and cellular signal transduction in eukaryotic cells. Maintenance of mitochondrial homeostasis is important for cellular function and survival.
Qiaochu Li +2 more
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Communications Biology, 2023 The proteasome plays key roles in synaptic plasticity and memory by regulating protein turnover, quality control, and elimination of oxidized/misfolded proteins. Here, we investigate proteasome function and localization at synapses in Alzheimer’s disease
Felipe C. Ribeiro +12 more
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Molecular Aspects of Medicine, 2009 Rising interest in the mechanism and function of the proteasomes and the ubiquitin system revealed that it is hard to find any aspect of the cellular metabolic network that is not directly or indirectly affected by the degradation system. This includes the cell cycle, the "quality control" of newly synthesized proteins (ERAD), transcription factor ...
Jung, Tobias +2 more
openaire +4 more sources
Proteasome beta-4 subunit contributes to the development of melanoma and is regulated by miR-148b
Tumor Biology, 2017 The proteasome beta-4 subunit is required for the assembly of 20S proteasome complex, forming a pivotal component for the ubiquitin–proteasome system. Emerging evidence indicates that proteasome beta-4 subunit may be involved in underlying progression ...
Xiaodong Zhang +7 more
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Proteasome activity and subunit composition in endometrial hyperplasia and cancer
Опухоли женской репродуктивной системы, 2014 In endometrial hyperplasia the total proteasome activity was not changed however the 26S proteasome activity was increased in comparison with the normal tissues.
L. V. Spirina +6 more
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Interplay between RNA Viruses and Promyelocytic Leukemia Nuclear Bodies
Veterinary Sciences, 2021 Promyelocytic leukemia nuclear bodies (PML NBs) are nuclear membrane-less sub structures that play a critical role in diverse cellular pathways including cell proliferation, DNA damage, apoptosis, transcriptional regulation, stem cell renewal ...
Sabari Nath Neerukonda
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Biochemical Pharmacology, 2015 Proteasome inhibitors have a 20 year history in cancer therapy. The first proteasome inhibitor, bortezomib (Velcade, PS-341), a break-through multiple myeloma treatment, moved rapidly through development from bench in 1994 to first approval in 2003. Bortezomib is a reversible boronic acid inhibitor of the chymotrypsin-like activity of the proteasome ...
Teicher, Beverly A. +1 more
openaire +2 more sources
Role of S5b/PSMD5 in Proteasome Inhibition Caused by TNF-α/NFκB in Higher Eukaryotes
Cell Reports, 2012 The ubiquitin-proteasome system is essential for maintaining protein homeostasis. However, proteasome dysregulation in chronic diseases is poorly understood.
Sang Mi Shim +5 more
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Aptamer-Hytac Chimeras for Targeted Degradation of SARS-CoV-2 Spike-1
CellsThe development of novel tools to tackle viral processes has become a central focus in global health, during the COVID-19 pandemic. The spike protein is currently one of the main SARS-CoV-2 targets, owing to its key roles in infectivity and virion ...
Carme Fàbrega +7 more
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Inhibitory Effect of b-AP15 on the 20S Proteasome
Biomolecules, 2014 The 26S proteasome is a cellular proteolytic complex containing 19S regulatory particles and the 20S core proteasome. It was reported that the small molecule b-AP15 targets the proteasome by inhibiting deubiquitination of the 19S regulatory particles of
Li Huang, Katherine Jung, Chin Ho Chen
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