Results 1 to 10 of about 98,536 (126)

The Proteasome Immunosubunit Multicatalytic Endopeptidase Complex-Like 1 Is a T-Cell-Intrinsic Factor Influencing Homeostatic Expansion [PDF]

Infection and Immunity, 2008
ABSTRACT Homeostatic regulatory mechanisms maintain the constant ratios between different lymphocyte subsets in the secondary lymphoid organs. How this dynamic equilibrium is achieved, in particular following the clonal expansion and subsequent contraction of different cells after infection, remains poorly understood.
Zaiss, Dietmar M W, de Graaf, Natascha, Sijts, Alice J A M   +2 more
openaire   +4 more sources

Constitutive and interferon-γ-induced expression of the human proteasome subunit multicatalytic endopeptidase complex-like 11EMBL accession number for MECL1 cDNA: Y13640.1

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1998
AbstractProteasomes generate peptides from intracellular endogenous and viral proteins for presentation by MHC class I molecules. During viral infection, interferon-γ (IFN-γ) acts as a cytokine altering the catalytic specificity of proteasomes by inducing the synthesis of the three proteasome subunits, low molecular weight protein (LMP) 2, LMP7 and ...
Foss, Grethe S, Larsen, Frank, Solheim, Jorun, Prydz, Hans   +3 more
openaire   +2 more sources

Akt1 Decreases Gcn5 Protein Stability through Regulating The Ubiquitin-Proteasome Pathway in Mouse Embryonic Fibroblasts [PDF]

Cell Journal, 2022
General control non-derepressible 5 (Gcn5) is a member of histone acetyltransferase (HAT) that plays key roles during embryogenesis as well as in the development of various human cancers.
Da Som Jeong, Yu Cheon Kim, Ji Hoon Oh, Myoung Hee Kim   +3 more
doaj   +1 more source

Contralateral parenchymal enhancement on MRI is associated with tumor proteasome pathway gene expression and overall survival of early ER+/HER2-breast cancer patients

Breast, 2021
Purpose: To assess whether contralateral parenchymal enhancement (CPE) on MRI is associated with gene expression pathways in ER+/HER2-breast cancer, and if so, whether such pathways are related to survival. Methods: Preoperative breast MRIs were analyzed
Max A.A. Ragusi, Tycho Bismeijer, Bas H.M. van der Velden, Claudette E. Loo, Sander Canisius, Jelle Wesseling, Lodewyk F.A. Wessels, Sjoerd G. Elias, Kenneth G.A. Gilhuijs   +8 more
doaj   +1 more source

Integrated transcriptome analysis identifies APPL1/RPS6KB2/GALK1 as immune-related metastasis factors in breast cancer

Open Medicine, 2023
The aim of this study is to investigate the prognostic immune-related factors in breast cancer (BC) metastasis. The gene expression chip GSE159956 was downloaded from the gene expression omnibus database.
Chen Gang, Zhang Kun, Liang Zhi, Zhang Song, Dai Yuanping, Cong Yizi, Qiao Guangdong   +6 more
doaj   +1 more source

Insights into CANDLE Syndrome

Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2020
Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome is a recently described chronic autoinflammatory disease, pathophysiologically related to intracellular proteasome/immunoproteasome dysfunction.
Katarina Kieselová, Felicidade Santiago, Martinha Henrique   +2 more
doaj   +1 more source

The shift from low to high non-structural protein 1 expression in rotavirus-infected MA-104 cells

Memorias do Instituto Oswaldo Cruz, 2013
A hallmark of group/species A rotavirus (RVA) replication in MA-104 cells is the logarithmic increase in viral mRNAs that occurs four-12 h post-infection.
Laura Martinez-Alvarez, Carolina Pina-Vazquez, Wilbert Zarco, Luis Padilla-Noriega   +3 more
doaj   +1 more source

Genes related to maintenance of autophagy and successful aging

Arquivos de Neuro-Psiquiatria
Considering aging as a phenomenon in which there is a decline in essential processes for cell survival, we investigated the autophagic and proteasome pathways in three different groups: young, older and oldest old male adults.
Carolina Fioroto Chaves, Diego Robles Mazzotti, Maysa Seabra Cendoroglo, Luiz Roberto Ramos, Sergio Tufik, Vanessa Cavalcante da Silva, Vânia D'Almeida   +6 more
doaj   +1 more source

Regulation via compartmentation: adaptive localization of the proteasome under stress. [PDF]

Biochem Soc Trans
Ciechanover A, Livneh I.
europepmc   +1 more source

The dual role of the ubiquitin-proteasome system in photomorphogenesis. [PDF]

Essays Biochem
Zhou H, Deng XW.
europepmc   +1 more source