Results 1 to 10 of about 16,539 (140)
Phloem sap from melon plants contains extracellular vesicles that carry active proteasomes which increase in response to aphid infestation. [PDF]
J Extracell VesiclesAbstract The morphogenesis of higher plants requires communication among distant organs throughout vascular tissues (xylem and phloem). Numerous investigations have demonstrated that phloem also act as a distribution route for signalling molecules being observed that different macromolecules translocated by the sap, including nucleic acids and proteins,
Sánchez-López CM +5 more
europepmc +2 more sources
The Proteasome Immunosubunit Multicatalytic Endopeptidase Complex-Like 1 Is a T-Cell-Intrinsic Factor Influencing Homeostatic Expansion [PDF]
Infection and Immunity, 2008 ABSTRACT Homeostatic regulatory mechanisms maintain the constant ratios between different lymphocyte subsets in the secondary lymphoid organs. How this dynamic equilibrium is achieved, in particular following the clonal expansion and subsequent contraction of different cells after infection, remains poorly understood.
Natascha de Graaf +3 more
openaire +4 more sources
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1998 Proteasomes generate peptides from intracellular endogenous and viral proteins for presentation by MHC class I molecules. During viral infection, interferon-gamma (IFN-gamma) acts as a cytokine altering the catalytic specificity of proteasomes by inducing the synthesis of the three proteasome subunits, low molecular weight protein (LMP) 2, LMP7 and ...
Hans Prydz +3 more
openaire +3 more sources
Aggregate, Volume 6, Issue 5, May 2025.Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai +6 more
wiley +1 more source
Journal of Neuroscience Research, Volume 103, Issue 5, May 2025.ABSTRACT Alzheimer's disease (AD) is a devastating form of dementia, with the number of affected individuals rising sharply. The main hallmarks of the disease include amyloid‐beta plaque deposits and neurofibrillary tangles consisting of hyperphosphorylated tau protein, besides other pathological features that contribute to the disease's complexity ...
Sally Kelliny +2 more
wiley +1 more source
Peptides From Animal and Fishery Byproducts: Uplifting the Functionality of Fifth Quarter
Food Science &Nutrition, Volume 13, Issue 4, April 2025.Recovery of peptide reduces pollution, increases return, and functionality of products. Meat byproducts and processing techniques raise the sustainability of the meat industry. These peptides can also be used as active components of the packaging system. Umami peptides are used as taste enhancers for the development of new products.
Akhilesh Kumar Verma +7 more
wiley +1 more source
The Peptide PROTAC Modality: A New Strategy for Drug Discovery
MedComm, Volume 6, Issue 4, April 2025.Peptide PROTAC is a bifunctional molecule generally composed of a target protein binding peptide (TBP), a linker peptide (LP), an E3 ligase binding peptide (EBP), and a delivery‐enhancing peptide (DEP), which can bind to the target protein (P) and E3 ligase (E3), inducing P to be labeled with ubiquitin (Ub) and subsequently recognized and degraded by ...
Youmin Zhu, Yu Dai, Yuncai Tian
wiley +1 more source
Physiological Reports, Volume 13, Issue 8, April 2025.Abstract Little is known on how a short‐term reduction of training volume changes muscle proteome and physiological parameters. We investigated the impact of halving training volume during regular training of cyclists on physiological parameters in relation to vastus lateralis protein profiles and fiber percentage ratios. Fifteen male cyclists (age: 30.
Pieter de Lange +14 more
wiley +1 more source
Oral SARS‐CoV‐2 Infection and Risk for Long Covid
Reviews in Medical Virology, Volume 35, Issue 2, March 2025.ABSTRACT SARS‐CoV‐2 is an oral pathogen that infects and replicates in mucosal and salivary epithelial cells, contributing to oral post‐acute sequelae COVID‐19 (PASC) and other oral and non‐oral pathologies. While pre‐existing inflammatory oral diseases provides a conducive environment for the virus, acute infection and persistence of SARS‐CoV‐2 can ...
Joel Schwartz +5 more
wiley +1 more source
Neuronal Ceroid Lipofuscinosis—Concepts, Classification, and Avenues for Therapy
CNS Neuroscience &Therapeutics, Volume 31, Issue 2, February 2025.This review comprehensively examined the pathogenic genes associated with various NCL subtypes, elucidating their roles, clinical presentations, corresponding mouse models, and the advances in clinical study of potential therapeutics. In particular, we clarified the potential of novel microglial cell replacement therapies in NCLs, providing hope for ...
Yuheng Zhang +4 more
wiley +1 more source