Results 21 to 30 of about 98,536 (126)

Genomic Analysis of Drosophila Neuronal Remodeling: A Role for the RNA-Binding Protein Boule as a Negative Regulator of Axon Pruning [PDF]

, 2008
Drosophila mushroom body (MB) {gamma} neurons undergo axon pruning during metamorphosis through a process of localized degeneration of specific axon branches.
Hoopfer, Eric D., Luo, Liqun, Penton, Andrea, Watts, Ryan J.   +3 more
core   +1 more source

Defining the organizational structure of dopamine and muscarninic acetylcholine receptors [PDF]

, 2015
No abstract ...
Alvarez-Curto, Elisa, Caltabiano, Gianluigi Caltabiano, Liste, María José Varela, Marsango, Sara, Milligan, Graeme   +4 more
core   +1 more source

Differential Gene Expression in Liver, Gill, and Olfactory Rosettes of Coho Salmon (Oncorhynchus kisutch) After Acclimation to Salinity. [PDF]

, 2015
Most Pacific salmonids undergo smoltification and transition from freshwater to saltwater, making various adjustments in metabolism, catabolism, osmotic, and ion regulation. The molecular mechanisms underlying this transition are largely unknown.
Bammler, Theo K, Beyer, Richard P, Farin, Federico M, Gallagher, Evan P, Hardiman, Gary, Lavado, Ramon, Maryoung, Lindley A, Schlenk, Daniel, Stapleton, Patricia L   +8 more
core   +1 more source

Genome-Wide Identification of Molecular Pathways and Biomarkers in Response to Arsenic Exposure in Zebrafish Liver [PDF]

, 2013
10.1371/journal.pone.0068737PLoS ONE87 ...
A Barchowsky, A De Vizcaya-Ruiz, A Diaz-Villasenor, A Donovan, A Mortazavi, A Ordas, AH Smith, AP Davis, AP Davis, AS Chan, AT McCurley, AT McKie, AT Nguyen, BE Bachmeier, BK Mandal, BM Forman, C Camaschella, CF Huang, CO Abernathy, D Chang, D Lyden, DB Tully, DC Radisky, DW Crabb, EG Beale, F Muller, FB Pichler, FP Guengerich, FQ Schafer, G Papanikolaou, G Schmitz, GM Brittenham, H Liu, H Shi, H Takagi, Hongyan Xu, HV Aposhian, HV Aposhian, I De Domenico, IG Woods, IG Woods, J Hellemans, J Liu, J Vandesompele, JH Lee, JH Postlethwait, JM Catchen, JP McGrath, K Jomova, K Larade, L Guo, L Shi, LT Vassilev, M Cavigelli, M Darabi, M Merkofer, M Schuliga, M Tenopoulou, MA Deeg, MA Rea, MC Hollander, MD Jacobs, MK Parr, MR de Castro, MS Hayden, MU Muckenthaler, NC Popescu, OW Stockhammer, P Arosio, P Ghosh, PC Adams, PJ Barter, PT Doulias, RC Habbersett, RC Kaltreider, RS Esworthy, RW Mahley, S Abboud, S Cai, S Fendorf, S Hasegawa, S Levi, S Maiti, SC Andrews, SH Lam, SH Lam, Siew Hong Lam, SJ Flora, SK Baird, SL Doyle, SM Cohen, SR Grossman, TD Gilmore, TK Hei, TP Dalton, W Huang da, W Zheng, W Zheng, Xiaoping Pan, XP Jiang, Y Haupt, Y Qiu, Yuan Shen, YW Zhang, Z Hegedus, Z Kosa, Zhiyuan Gong   +106 more
core   +9 more sources

HIV-1 Tat protein modulates the generation of cytotoxic T cell epitopes by modifying proteasome composition and enzymatic activity [PDF]

, 2004
Tat, the trans activation protein of HIV, is produced early upon infection to promote and expand HIV replication and transmission. However, Tat appears to also have effects on target cells, which may affect Ag recognition both during infection and after ...
Bonaccorsi, A, Bottoni, A, Cafaro, A, Canella, Alessandro, Caputo, A, Ensoli, B., Fabris, M, Fortini, Cinzia, Gallerani, Eleonora, Gavioli, Riccardo, Marastoni, Mauro, Micheletti, F, Rimessi, P   +12 more
core   +2 more sources

A self-compartmentalizing hexamer serine protease from Pyrococcus Horikoshii: Substrate selection achieved through multimerization [PDF]

, 2013
Oligopeptidases impose a size limitation on their substrates, the mechanism of which has long been in debate. Here we present the structure of a hexameric serine protease, an oligopeptidase from Pyrococcus horikoshii (PhAAP), revealing a complex, self ...
Aertgeerts, Afonine, Anna Kiss-Szemán, Balázs Hornung, Biswal, Bjelkmar, Bosch, Cha, Chen, Chiti, Clark, Collaborative Computational Project, Number 4, Cowtan, Dobson, Duysen, Dóra K. Menyhárd, Eldrup, Emsley, Engel, Engel, Erlandsson, Franken, Fuxreiter, Fülöp, Goettig, Gábor Náray-Szabó, Harmat, Hess, Hiramatsu, Hofmann, Ilona Szamosi, Joshua-Tor, Juhász, Kabsch, Kim, Kim, Kiss, Kiss, Klarissza Domokos, Krisztina Rádi, Li, László Polgár, Mackerell, Maurer-Stroh, McLuskey, Medrano, Monincová, Monsellier, Murshudov, Naylor, Palmieri, Pathak, Polgár, Prokop, Richards, Richardson, Rould, Scaloni, Schmidt, Shan, Shan, Sheldrick, Soldi, Stefani, Szeltner, Szeltner, Szeltner, Thoms, Vagin, Vaguine, Veronika Harmat, Zhang, Zoltán Szeltner, Éva Tichy-Rács   +73 more
core   +1 more source

Review of the Rpt3 Genes Encoding Part of the 26S Proteasome Associated with Loci Underlying Disease Resistance in Soybean [PDF]

, 2012
The 26S proteasomal complex is a multifunctional proteolytic machinery of the cell. The proteasome plays role in myriad of cellular functions, which have been further diversified by its separable proteolytic and non-proteolytic sub-complexes.
Bhaumik, Sukesh, Lightfoot, David A, Malik, Shivani   +2 more
core   +3 more sources

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Prediction of protein complexes in Trypanosoma brucei by protein correlation profiling mass spectrometry and machine learning [PDF]

, 2017
A disproportionate number of predicted proteins from the genome sequence of the protozoan parasite Trypanosoma brucei, an important human and animal pathogen, are hypothetical proteins of unknown function.
Angus I. Lamond, Clemmens, Ferguson, Gazestani, Gazestani, Li, Lueong, Mark Larance, Mauxion, Michael A. J. Ferguson, Michele Tinti, Salavati, Thomas W. M. Crozier   +12 more
core   +3 more sources

First genome sequence of a European Alternaria brassicae isolate and genes involved in early development of alternaria leaf spot on Brassica juncea

Pest Management Science, EarlyView.
This article reports the first genome sequence of a UK Alternaria brassicae isolate. Dual RNA‐sequencing profiling of A. brassicae‐infected Brassica juncea leaves identified differentially expressed genes involved in pathogenicity and host response pathways in moderately resistant Sej‐2 (2) and moderately susceptible Pusa Jaikisan cultivars.
Kevin M. King, Graham McLaughlin, Chinthani S. Karandeni Dewage, Zedi Gao, David J. Hughes, Jonathan S. West, Henrik U. Stotz   +6 more
wiley   +1 more source