Results 31 to 40 of about 16,539 (140)

Vitamin K‐dependent gamma‐carboxyglutamic acid protein 1 promotes pancreatic ductal adenocarcinoma progression through stabilizing oncoprotein KRAS and tyrosine kinase receptor EGFR

Clinical and Translational Medicine, Volume 15, Issue 1, January 2025.
Abstract Background Vitamin K‐dependent γ‐glutamic acid carboxylation (Gla) proteins are calcium‐binding and membrane‐associated, participating in coagulation, bone turnover, and cancer biology. The molecular function of transmembrane proline‐rich Gla proteins (PRRGs) remains unexplored.
Zheng Wu, Qing Ye, Shan Zhang, Li‐Peng Hu, Xiao‐Qi Wang, Lin‐Li Yao, Lei Zhu, Shu‐Yu Xiao, Zong‐Hao Duan, Xue‐Li Zhang, Shu‐Heng Jiang, Zhi‐Gang Zhang, De‐Jun Liu, Dong‐Xue Li, Xiao‐Mei Yang   +14 more
wiley   +1 more source

Defining the organizational structure of dopamine and muscarninic acetylcholine receptors [PDF]

, 2015
No abstract ...
Alvarez-Curto, Elisa, Caltabiano, Gianluigi Caltabiano, Liste, María José Varela, Marsango, Sara, Milligan, Graeme   +4 more
core   +1 more source

Genomic Analysis of Drosophila Neuronal Remodeling: A Role for the RNA-Binding Protein Boule as a Negative Regulator of Axon Pruning [PDF]

, 2008
Drosophila mushroom body (MB) {gamma} neurons undergo axon pruning during metamorphosis through a process of localized degeneration of specific axon branches.
Hoopfer, Eric D., Luo, Liqun, Penton, Andrea, Watts, Ryan J.   +3 more
core   +1 more source

HDAC3 in action: Expanding roles in inflammation and inflammatory diseases

Cell Proliferation, Volume 58, Issue 1, January 2025.
HDAC3, a member of the histone deacetylase (HDAC) superfamily, is involved in the regulation of acetylation/deacetylation processes associated with inflammation‐related diseases. This article reviews the key role of HDAC3 in the process of inflammation, the potential molecular mechanism and the clinical significance of targeted therapy.
Ruyuan He, Zhuokun He, Tianyu Zhang, Bohao Liu, Minglang Gao, Ning Li, Qing Geng   +6 more
wiley   +1 more source

Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia [PDF]

, 2014
BACKGROUND: Evidence from cachectic cancer patients and animal models of cancer cachexia supports the involvement of Forkhead box O (FoxO) transcription factors in driving cancer-induced skeletal muscle wasting. However, the genome-wide gene networks and
Beharry, Adam W., Ferreira, Leonardo F., Judge, Andrew R., Judge, Sarah M., Kandarian, Susan C., Roberts, Brandon M., Wu, Chia-Ling   +6 more
core   +1 more source

Role of Tau Protein Hyperphosphorylation in Diabetic Retinal Neurodegeneration

Journal of Ophthalmology, Volume 2025, Issue 1, 2025.
Diabetic retinal neurodegeneration (DRN) is an early manifestation of diabetic retinopathy (DR) characterized by neurodegeneration that precedes microvascular abnormalities in the retina. DRN is characterized by apoptosis of retinal ganglion cells (involves alterations in retinal ganglion cells [RGCs], photoreceptors, amacrine cells and bipolar cells ...
Jingyu Mu, Zengrui Zhang, Chao Jiang, Haoming Geng, Junguo Duan, Hamid Ahmadieh   +5 more
wiley   +1 more source

Differential Gene Expression in Liver, Gill, and Olfactory Rosettes of Coho Salmon (Oncorhynchus kisutch) After Acclimation to Salinity. [PDF]

, 2015
Most Pacific salmonids undergo smoltification and transition from freshwater to saltwater, making various adjustments in metabolism, catabolism, osmotic, and ion regulation. The molecular mechanisms underlying this transition are largely unknown.
Bammler, Theo K, Beyer, Richard P, Farin, Federico M, Gallagher, Evan P, Hardiman, Gary, Lavado, Ramon, Maryoung, Lindley A, Schlenk, Daniel, Stapleton, Patricia L   +8 more
core   +1 more source

DeSUMOylating isopeptidase 1 participates in the faithful chromosome segregation and vincristine sensitivity

The FASEB Journal, Volume 38, Issue 24, 31 December 2024.
DeSUMOylating isopeptidase 1 (DESI1), a member of the second class of SUMO protease, maintains the expression level of Aurora B to promote the spindle assembly checkpoint. DESI1 is required for the activity of FoxM1 in the transcription of mitotic regulators including Aurora B.
Yuki Ikeda, Ryuzaburo Yuki, Youhei Saito, Yuji Nakayama   +3 more
wiley   +1 more source

Expresión diferencial de genes en Pyropia columbina (Bangiales, Rhodophyta) bajo hidratación y desecación natural [PDF]

, 2013
Indexación: Web of Science; Scielo.RESUMEN. En Zonas Costeras rocosas, la desecación es gatillada porción Cambios Diarios en los Niveles de marea, y la Evidencia indica experimental de Me Distribución de las algas en la zona intermareal no está ...
Contreras-Porcia, Loretto, Correa, Juan A., Fierro, Camila, Flores-Molina, María Rosa, Guajardo, Eduardo, Kube, Michael, Lovazzano, Carlos, López-Cristoffanini, Camilo, Núñez, Alejandra, Reinhardt, Richard, Thomas, Daniela   +10 more
core  

Large‐scale deep proteomic analysis in Alzheimer's disease brain regions across race and ethnicity

Alzheimer's &Dementia, Volume 20, Issue 12, Page 8878-8897, December 2024.
Abstract INTRODUCTION Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, yet our comprehension predominantly relies on studies within non‐Hispanic White (NHW) populations. Here we provide an extensive survey of the proteomic landscape of AD across diverse racial/ethnic groups.
Fatemeh Seifar, Edward J. Fox, Anantharaman Shantaraman, Yue Liu, Eric B. Dammer, Erica Modeste, Duc M. Duong, Luming Yin, Adam N. Trautwig, Qi Guo, Kaiming Xu, Lingyan Ping, Joseph S. Reddy, Mariet Allen, Zachary Quicksall, Laura Heath, Jo Scanlan, Erming Wang, Minghui Wang, Abby Vander Linden, William Poehlman, Xianfeng Chen, Saurabh Baheti, Charlotte Ho, Thuy Nguyen, Geovanna Yepez, Adriana O. Mitchell, Stephanie R. Oatman, Xue Wang, Minerva M. Carrasquillo, Alexi Runnels, Thomas Beach, Geidy E. Serrano, Dennis W. Dickson, Edward B. Lee, Todd E. Golde, Stefan Prokop, Lisa L. Barnes, Bin Zhang, Varham Haroutunian, Marla Gearing, James. J Lah, Philip De Jager, David A Bennett, Anna Greenwood, Nilüfer Ertekin‐Taner, Allan I. Levey, Aliza Wingo, Thomas Wingo, Nicholas T. Seyfried   +49 more
wiley   +1 more source