Results 51 to 60 of about 98,536 (126)

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, Volume 15, Issue 11, Page 1874-1885, November 2025.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

Ubiquitylation activates a peptidase that promotes cleavage and destabilization of its activating E3 ligases and diverse growth regulatory proteins to limit cell proliferation in Arabidopsis [PDF]

, 2017
The characteristic shapes and sizes of organs are established by cell proliferation patterns and final cell sizes, but the underlying molecular mechanisms coordinating these are poorly understood.
Bevan, Michael W, Chen, Liangliang, Dissmeyer, Nico, Dong, Hui, Dumenil, Jack, Gonzalez Sanchez, Nathalie, Inzé, Dirk, Klecker, Maria, Li, Yunhai, Lu, Fu-Hao, McKenzie, Neil, Na, Li, Naumann, Christin, Prior, Rachel, Saalbach, Gerhard, Seguela, Mathilde, Smith, Caroline, Vanhaeren, Hannes, Xia, Tian   +18 more
core   +2 more sources

A proteinaceous organic matrix regulates carbonate mineral production in the marine teleost intestine [PDF]

, 2016
Marine teleost fish produce CaCO(3) in their intestine as part of their osmoregulatory strategy. This precipitation is critical for rehydration and survival of the largest vertebrate group on earth, yet the molecular mechanisms that regulate this ...
Adrian Pelin, Christophe M. R. LeMoine, Kevin L. Schauer, M. Danielle McDonald, Martin Grosell, Nicolas Corradi, Wesley C. Warren   +6 more
core   +2 more sources

A Photocaged N‐Phosphonopiperidinone as a Selective Photo‐Cleavable DPP8/9 Inhibitor

ChemBioChem, Volume 26, Issue 19, October 3, 2025.
Photocaged inhibitors are versatile biochemical tools for spatiotemporal control of inhibitor activity, facilitating the elucidation of protein function in a cell type‐dependent fashion. Herein, a green light‐cleavable, BODIPY‐photocaged dipeptidyl peptidase 8 and 9 inhibitor with low phototoxicity, pronounced potency, and selectivity is described ...
Leonard Sewald, Niko Molke, Werner W. A. Tabak, Anette Haak, Maja Najdzion, Ruth Geiss‐Friedlander, Doris Hellerschmied, Robert Huber, Markus Kaiser   +8 more
wiley   +1 more source

Expresión diferencial de genes en Pyropia columbina (Bangiales, Rhodophyta) bajo hidratación y desecación natural [PDF]

, 2013
Indexación: Web of Science; Scielo.RESUMEN. En Zonas Costeras rocosas, la desecación es gatillada porción Cambios Diarios en los Niveles de marea, y la Evidencia indica experimental de Me Distribución de las algas en la zona intermareal no está ...
Contreras-Porcia, Loretto, Correa, Juan A., Fierro, Camila, Flores-Molina, María Rosa, Guajardo, Eduardo, Kube, Michael, Lovazzano, Carlos, López-Cristoffanini, Camilo, Núñez, Alejandra, Reinhardt, Richard, Thomas, Daniela   +10 more
core  

CellTree: an R/bioconductor package to infer the hierarchical structure of cell populations from single-cell RNA-seq data [PDF]

, 2016
GO BP Terms for myoblast data. Full table of enriched GO BP terms for each topic in myoblast data.
David A. duVerle, Hiroyuki Aburatani, Koji Tsuda, Seitaro Nomura, Sohiya Yotsukura   +4 more
core   +10 more sources

The Lrs14‐Like AbfR1 Homolog From Metallosphaera sedula Is a Nucleoid‐Organizing Protein

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
Nucleoid organization in Crenarchaeota involves diverse small DNA‐binding proteins. The Lrs14‐type protein AbfR1 from Metallosphaera sedula binds nonsequence specifically across the genome and induces DNA condensation. These findings suggest a structural role for AbfR1Ms in chromatin architecture, functionally resembling bacterial nucleoid‐associated ...
Veerke De Kock, Ronnie Willaert, Yannick Gansemans, Filip Van Nieuwerburgh, Rani Baes, Eveline Peeters   +5 more
wiley   +1 more source

Extensive differential protein phosphorylation as intraerythrocytic Plasmodium falciparumschizonts develop into extracellular invasive merozoites [PDF]

, 2015
Pathology of the most lethal form of malaria is caused by Plasmodium falciparum asexual blood stages and initiated by merozoite invasion of erythrocytes.
Grainger, Munira, Green, Judith L., Holder, Anthony A., Langsley, Gordon, Lasonder, Edwin   +4 more
core   +1 more source

Investigating the Interaction Profile of Unconjugated Ubiquitin: Chemical Biology and Affinity Enrichment Mass Spectrometric Approaches

ChemBioChem, Volume 26, Issue 18, September 18, 2025.
This mini review provides insights into the synergistic power of chemical biology techniques for generating defined ubiquitin (Ub) variants and the use of affinity enrichment mass spectrometry to decipher the Ub code. It focuses on unconjugated Ub variants, which have emerged as additional signaling molecules in the Ub lexicon. Furthermore, it outlines
Simon Maria Kienle, Katrin Stuber
wiley   +1 more source

Combinatorial omics analysis reveals perturbed lysosomal homeostasis in collagen VII-deficient keratinocytes [PDF]

, 2018
The extracellular matrix protein collagen VII is part of the microenvironment of stratified epithelia and critical in organismal homeostasis. Mutations in the encoding gene COL7A1 lead to the skin disorder dystrophic epidermolysis bullosa (DEB), are ...
Athanasiou, Ioannis, Backofen, Rolf, Bornert, Olivier, Bruckner-Tuderman, Leena, Dengjel, Jörn, Erxleben, Anika, Grüning, Björn Andreas, Has, Cristina, Kiritsi, Dimitra, Leppert, Juna, Nyström, Alexander, Reinheckel, Thomas, Thriene, Kerstin, Weber, Ekkehard   +13 more
core   +1 more source