CNS Neuroscience &Therapeutics, Volume 30, Issue 10, October 2024.Imbalance in the gut microbiota triggers neuroinflammation, thereby promoting the progression of Alzheimer's disease. Modulating the gut microbiota may reverse this process, offering a new strategy for the treatment of AD. Such interventions through the gut–brain axis pave new avenues for the prevention and treatment of AD. This figure was created with
Jianshe Yang +6 more
wiley +1 more source
Review of the Rpt3 Genes Encoding Part of the 26S Proteasome Associated with Loci Underlying Disease Resistance in Soybean [PDF]
, 2012 The 26S proteasomal complex is a multifunctional proteolytic machinery of the cell. The proteasome plays role in myriad of cellular functions, which have been further diversified by its separable proteolytic and non-proteolytic sub-complexes.
Bhaumik, Sukesh +2 more
core +3 more sources
The FASEB Journal, Volume 38, Issue 16, 31 August 2024.The transcriptome and proteome changes caused by the overexpression of Maf1 in the protozoan parasite Leishmania major suggest the participation of this protein in multiple key biological processes. Abstract Maf1, originally described as a repressor of RNA polymerase III (RNAP III) transcription in yeast, participates in multiple functions across ...
Luis A. Rivera‐Rivas +7 more
wiley +1 more source
A self-compartmentalizing hexamer serine protease from Pyrococcus Horikoshii: Substrate selection achieved through multimerization [PDF]
, 2013 Oligopeptidases impose a size limitation on their substrates, the mechanism of which has long been in debate. Here we present the structure of a hexameric serine protease, an oligopeptidase from Pyrococcus horikoshii (PhAAP), revealing a complex, self ...
Aertgeerts +73 more
core +1 more source
Extensive differential protein phosphorylation as intraerythrocytic Plasmodium falciparumschizonts develop into extracellular invasive merozoites [PDF]
, 2015 Pathology of the most lethal form of malaria is caused by Plasmodium falciparum asexual blood stages and initiated by merozoite invasion of erythrocytes.
Grainger, Munira +4 more
core +1 more source
Patterns of Evolutionary Conservation and Divergence in the Short-Term Hyposalinity Stress Response of a Euryhaline Diatom, Skeletonema marinoi [PDF]
, 2022 Survival under fluctuating environmental conditions, such as those increasing in frequency and magnitude under environmental change, requires a successful response to stress.
Judy, Kathryn
core +1 more source
Proteomic Analysis of Human Urinary Exosomes [PDF]
, 2009 Exosomes originate as the internal vesicles of multivesicular bodies (MVBs) in cells. These small vesicles (40-100 nm) have been shown to be secreted by most cell types throughout the body.
Gonzales, Patricia Amalia
core
Combinatorial omics analysis reveals perturbed lysosomal homeostasis in collagen VII-deficient keratinocytes [PDF]
, 2018 The extracellular matrix protein collagen VII is part of the microenvironment of stratified epithelia and critical in organismal homeostasis. Mutations in the encoding gene COL7A1 lead to the skin disorder dystrophic epidermolysis bullosa (DEB), are ...
Athanasiou, Ioannis +13 more
core +1 more source
Biomarcadores salivares no cancro da cabeça e pescoço [PDF]
, 2022 Head and neck cancer (HNC) are a group of cancers which occur in the organs from the anatomical area referred. The HNC staging system is generalized for most subtypes of HNC and restricted for the seven classifying stages of this cancer, which affects ...
Rentroia, Mara Ivone Santos
core
Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo [PDF]
, 2018 Prolyl oligopeptidase (PREP) inhibition by small-molecule inhibitors can reduce alpha-synuclein (aSyn) aggregation, a key player in Parkinson's disease pathology.
Julku, Ulrika Hannele +3 more
core +2 more sources