Results 61 to 70 of about 13,911 (169)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Resveratrol protects against triclosan–induced impairment of colonic barrier function in chickens

Poultry Science
Triclosan (TCS) is a widely used antimicrobial agent, and chronic exposure has been reported to impair intestinal barrier function and induce oxidative stress and inflammation.
Yixin Zhang, Huayu Zhang, Qiushi Li, Fucheng Wang, Tianning Luo, Qiaochu Sun, Wen Zhang   +6 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Mitogenome Phylogenetics of Spiruromorpha Porpoise Parasite: Insights Into Phylogeny of Crassicauda magna

Pathogens
(1) Background: Crassicauda magna is a major parasite of large porpoises and whales and has been classified in the Habronematoidea family. However, there has been a great controversy regarding its classification.
Lei Han, Yuling Yang, Maolin Lu, Hongyan Yu, Yaxian Lu, Mengchao Zhou, Tianlu Liu, Ruisi Zhang, Bingyao Chen, Zhijun Hou   +9 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

A consensus genome of sika deer (Cervus nippon) and transcriptome analysis provided novel insights on the regulation mechanism of transcript factor in antler development

BMC Genomics
Background Sika deer (Cervus nippon) holds significance among cervids, with three genomes recently published. However, these genomes still contain hundreds of gaps and display significant discrepancies in continuity and accuracy. This poses challenges to
Qianghui Wang, Ruobing Han, Haihua Xing, Heping Li   +3 more
doaj   +1 more source

Astragaloside IV Alleviates Trueperella pyogenes-Induced Endometritis via the Nrf2/HO-1 Signaling Pathway

Antioxidants
The increasing antimicrobial resistance of T. pyogenes, one of the principal pathogens associated with endometritis, presents a formidable challenge in veterinary medicine.
Chunyang Gou, Hetian Mu, Yueting Wang, Yanan Liu, Ziqi Peng, Yun Li, Mingwei Xing, Maozhen Qi   +7 more
doaj   +1 more source

First cloning, tissue-specific expression and molecular characterization of rig-i gene in whooper swan [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi
To investigate the molecular characteristics of the RIG-I gene of whooper swan, RIG-I gene was cloned, sequenced and characterized, and the relative expression levels of the RIG-I gene in five tissues of whooper swans were determined by Real-time ...
Guangli LI, Xinhao LU, Wangjuan HU, Ru DING, Jiaqi LAN, Jinyan WU, Jiali ZHU, Xueqi TAN, Lanlan LIU, Xiangwei ZENG   +9 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

A proton-gated channel identified in the centipede antenna

EMBO Reports
Acid sensing is essential for various biological processes in animals, yet it exhibits species-specific characteristics. In this study, we identified a proton-dissociation-permeated sodium channel (PDPNaC1) in the antennal sensory neurons of the ...
Wenqi Dong, Licheng Yuan, Jiangming Shang, Fan Yang, Shilong Yang, Xiancui Lu, Qian Wang, Anna Luo, Jiheng Geng, Jiatong Cheng, Runze Li, Yunfei Wang   +11 more
doaj   +1 more source