Results 81 to 90 of about 436,780 (305)

The complete mitochondrial genome of the Rana kukunoris (Anura: Ranidae) from Inner Mongolia, China

Mitochondrial DNA. Part B. Resources, 2020
We determined the whole mtNDA genome of the Plateau brown frog (Rana kukunoris) in Helan Mountains, Inner Mongolia. The complete mitochondrial genome consists of 13 protein-coding, 22 tRNA, 2 rRNA genes, and 1 control region (CR), and its total length is
Jifei Wang, Zongzhi Li, Hui Gao, Zhensheng Liu, Liwei Teng   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Untangling the Benefits of Protected Areas in Fisheries [PDF]

Studies of marine protected areas as a tool for fisheries management have shown that protected areas have the potential to improve the level of resource rent generated in the fishery.
Greenville, Jared W., MacAulay, T. Gordon   +1 more
core   +1 more source

Understanding the interactions among local communities, protected areas and tourism: case studies of Kruger National Park and Purnululu National Park [PDF]

, 2010
New management approaches for protected areas emphasise a 'humans in nature' perspective, with protected areas seen as intrinsically connected with surrounding human populations. Tourism often provides a connection between these communities and protected
Strickland-Munro, Jennifer. K.
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

International Workshop on Indigenous Communities and Government Partnerships for Protected Area Management: Workshop Summary Report [PDF]

The International Workshop on Indigenous Communities and Government Partnerships for Protected Area Management was held on September 2022 on the homelands of the Lower Elwha Klallam Tribe.
International Workshop on Indigenous Communities and Government Partnerships for Protected Area Management
core   +1 more source

The Status of Wildlife in Protected Areas Compared to Non-Protected Areas of Kenya

PLoS ONE, 2009
نقوم بتجميع أكثر من 270 تعدادًا للحياة البرية في كينيا على مدار الثلاثين عامًا الماضية لمقارنة الاتجاهات في المتنزهات والمحميات الوطنية مع النظم الإيكولوجية المجاورة والاتجاهات على مستوى البلاد. تظهر الدراسة أهمية التمييز بين التغيرات التي يسببها الإنسان من التذبذبات السكانية الطبيعية المتعلقة بهطول الأمطار والعوامل البيئية.
David Western, Samantha Russell, Innes C. Cuthill   +2 more
openaire   +5 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Long-term trends in the use of a protected area by small cetaceans in relation to changes in population status [PDF]

, 2014
The BES, ASAB, Greenpeace Environmental Trust, Scottish Natural Heritage, Scottish Government, Whale and Dolphin Conservation, Talisman Energy (UK) Ltd., Department of Energy and Climate Change, Chevron, Natural Environment Research Council (NERC) and ...
Islas Villanueva, Valentina, Ross Corkrey, Corkery, Ross, Ben Wilson, Quick, Nicola Jane, Durban, John W., Islas-Villanueva, Valentina, Philip S. Hammond, Vincent M. Janik, Susan M. Lusseau, Janik, Vincent M., Corkrey, Ross, Parsons, Kim M., Valentina Islas-Villanueva, John W. Durban, Thompson, Paul M., Barbara Cheney, Grellier, Kate, Thompson, Paul, Lusseau, Susan M., Kate Grellier, Nicola J. Quick, Hammond, Philip S., Lusseau, Susan, Quick, Nicola J., Cheney, Barbara, Durban, John, Kim M. Parsons, Hammond, Philip Steven, Wilson, Ben, Parsons, Kim, Paul M. Thompson   +31 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source