Results 71 to 80 of about 436,780 (305)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Priorities for protected area research [PDF]

, 2018
A hundred research priorities of critical importance to protected area management were identified by a targeted survey of conservation professionals; half researchers and half practitioners.
Ferraro, Paul, Gaston, Kevin J., Foden, Wendy, Hickey, Valerie, Makombo, John, Bianco, Mariasole, Kettunen, Marianne, Laestadius, Lars, Dearden, Phil, Laffoley, Dan, Lichtenstein, Gabriela, Karapetyan, Areg, Cook, Carly, Irving, Jason, Marshall, Nina, Stolton, Sue, Amend, Thora, Day, Jon C., Nguyen, Dao, Paxton, Midori, Gambino, Roberto, McGeoch, Melodie, Badola, Ruchi, Lham, Dechen, Dudley, Nigel, Edwards, Mary, Nogué, Sandra, Hockings, Marc, Hayward, Natalie, Chettri, Nakul, Jeffries, Bruce   +30 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Tourism – protected area partnerships in Australia: designing and managing for success [PDF]

, 2008
Partnerships are increasingly being regarded as essential for sustainable protected area tourism. They are a pivotal part of increasing efforts by protected area agencies to encourage more involvement by the private sector and local communities in ...
Laing, J.H., Wegner, A., Laing, J., Pfueller, S., Moore, S., Weiler, B., Croy, G., Lockwood, M., Moore, S.A., Lee, D.   +9 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Developing a national approach to visitor data collection, management and use for protected areas: thoughts from Australian research and practice [PDF]

, 2008
Information on visitor numbers, activities, expectations and satisfaction is vital for protected areas managers on two counts: to assist in the provision of the services and facilities that visitors need and want; and to determine if managers have been ...
Griffin, T., Darcy, S., Moore, S.A., Crilley, G.   +3 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

jeffreyhanson/global-protected-areas: Developmental release [PDF]

, 2016
Automatically download and clean global protected area ...
Jeff Hanson
core   +1 more source

Exploring Alashan Ground Squirrel (Spermophilus alashanicus) Diversity: Metagenomic and Transcriptomic Datasets from the Helan Mountains

Scientific Data
This study investigates the adaptive strategies of the Alashan Ground Squirrel (Spermophilus alashanicus) in response to habitat changes, as rodents are sensitive indicators of ecosystem changes.
Yao Zhao, Siwei Deng, Zhirong Zhang, Junda Chen, Liwei Teng, Zhensheng Liu   +5 more
doaj   +1 more source