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Expression of protective antigen in transgenic plants: a step towards edible vaccine against anthrax
Biochemical and Biophysical Research Communications, 2002 Protective antigen (PA) is the most potent molecule for vaccination against anthrax. In the present study, we have successfully integrated protective antigen gene in nuclear genome of tobacco plants by Agrobacterium mediated leaf-disc transformation ...
Mohammad Azhar Aziz +2 more
exaly +2 more sources
Microbial Pathogenesis, 2005 The protective antigen (PA) component of the anthrax toxins is an essential virulence factor of Bacillus anthracis and is the major protective immunogen. The kinetics of PA production during growth of B.
C K Coté +2 more
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Antigenic: An improved prediction model of protective antigens
Artificial Intelligence in Medicine, 2019An antigen is a protein capable of triggering an effective immune system response. Protective antigens are the ones that can invoke specific and enhanced adaptive immune response to subsequent exposure to the specific pathogen or related organisms. Such proteins are therefore of immense importance in vaccine preparation and drug design.
Mohammad Saifur Rahman 0001 +4 more
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Nematode antigens in protection, diagnosis and pathology
Veterinary Immunology and Immunopathology, 1987A thorough study of parasite antigens is a prerequisite for control programmes based on protection by vaccination, accurate serodiagnosis and perhaps immune modulation to diminish pathological sequelae. Stage specific surface secreted and somatic antigens may be of particular value in proceeding towards these goals.
R M, Parkhouse +3 more
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Protective Cellular Antigen of Clostridium chauvoei
American Journal of Veterinary Research, 1980SUMMARY Cellular antigens of Clostridium chauvoei, strain IRP-128, were demonstrated to be important in induction of immunity against this bacterium in guinea pigs. At least one major component of the cellular antigen complex was heat-labile. Acid extraction of the bacterial cells, followed by selective purification for flagella, led to the preparation
J R, Stevenson, K A, Stonger
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Protective antigens in brucellosis
Annales de l'Institut Pasteur / Microbiologie, 1987International ...
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Molecular cloning of a protective antigen of schistosomes
Nature, 1987The complementary DNA sequence encoding the Mr 28,000 antigen of Schistosoma mansoni has been isolated and expressed in Escherichia coli. Experimental vaccination of rats, hamsters and monkeys with a recombinant fusion protein induces a strongly cytotoxic antibody response.
J M, Balloul +8 more
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Localization of protective antigens in Trighostrongylus colubriformis
International Journal for Parasitology, 1991In order to localize protective antigens in Trichostrongylus colubriformis, adult worms were microdissected and the capacity of worm tissues to protect guinea pigs against infection examined. The results suggest that T. colubriformis protective antigens are widely distributed in the body and are not concentrated in the intestine or glandular structures.
T L, Rothwell, N C, Sangster
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Hsp70 in parasites: as an inducible protective protein and as an antigen
Experientia, 1994The heat shock (HS) response is a general homeostatic mechanism that protects cells and the entire organism from the deleterious effects of environmental stresses. It has been demonstrated that heat shock proteins (HSP) play major roles in many cellular processes, and have a unique role in several areas of cell biology, from chronic degenerative ...
MARESCA, Bruno, G. S. Kobayashi
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