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Characterization of protective antigens and the protective immune response

Veterinary Microbiology, 1993
The protective immune response to a vaccine may be due to the presence of circulating antibody (humoral immunity), the actions of sensitized T-lymphocytes (cell-mediated immunity), the presence of secretory IgA on mucosal surfaces (mucosal immunity), or a combination of these factors. In general, humoral immunity is felt to be particularly important in
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Specificity of Trichostrongylus colubriformis Protective Antigens

The Journal of Parasitology, 1981
FIGURE 1. Circulating antigens in the serum of a cynomolgus macaque infected with tetrathyridia in M. corti. Center well (c) contains RAS/E; wells 1 to 3 contain serum from host number 1 (splenectomized) at days 91, 98, 105 p.i.; wells 4 to 6 contain serum from host number 2 (intact) for the same time periods.
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A HEAT STABLE PROTECTIVE STAPHYLOCOCCAL ANTIGEN

Australian Journal of Experimental Biology and Medical Science, 1960
SUMMARYA strain of staphylococci, chosen for the very marked enhancement by mucin of its intraperitoneal virulence to mice, was cultured in sloppy agar.The supernatant fluids obtained were of low toxicity and were highly potent as active immunizing agents in mice against lethal intraperitoneal challenge by the homologous strain in mucin suspension. The
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Hymenolepis diminuta: The origin of protective antigens

Experimental Parasitology, 1982
Abstract Mice were infected orally with 1,6, or 30 cysticercoids of Hymenolepis diminuta . These were allowed to develop for different periods of time before elimination with anthelminthic, thus exposing the hosts to antigens from the prestrobilate, early strobilate, or fully strobilate worms.
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A Soluble Protective Antigen of Trypanosoma brucei

Nature, 1960
Trypanosoma brucei in quantities sufficient for antigenic analysis was obtained by harvesting the blood of rats on the third day of infection by the protozoon, when the fulminating parasitaemia is at its height. The trypanosomes were separated from the blood by centrifugation and the resulting mash was preserved by freeze drying.
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Finding Protective Bacterial Antigens

2012
Current vaccine development efforts are mainly focused on opportunistic pathogens that are frequent colonizers and have complex pathogenesis and interaction with the human host. Therefore, more sophisticated and comprehensive vaccine development approaches have to be considered than for strictly pathogenic bacteria with well-defined virulence ...
Guido Grandi, Eszter Nagy
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The protective antigen of malarial sporozoites (Plasmodium berghei) is a differentiation antigen.

The Journal of Immunology, 1981
Abstract Pb44, the protective antigen of rodent malaria sporozoite (Plasmodium berghei) covers the entire surface of mature, salivary gland sporozoites. This antigen is undetectable in approximately 50% of the immature, i.e., oocyst sporozoites. On the surface of the remaining oocyst sporozoites, Pb44 is found in patches. Pb44 is present
M, Aikawa   +3 more
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Protective Antigens of Vibrio Cholerae

1989
The disease cholera in the epidemic form is mainly caused by the gram- negative bacterium Vibrio cholerae, belonging to the 01 serovar. The or-ganism also exists in two serotypes (Inaba and Ogawa) and biotypes (clas-sical and El Tor). It is known that the diarrheagenic syndrome in cholera patients is primarily caused by an enterotoxin (cholera toxin ...
Asoke C. Ghose, Chiranjib Dasgupta
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Plasmodium berghei: Selective release of “protective” antigens

Experimental Parasitology, 1977
Abstract BALB c mice infected with Plasmodium berghei produced high levels of immunoglobulins after the first peak parasitemia at which time the malaria parasites were mainly present in reticulocytes and not in oxyphilic red blood cells. Attempts at active immunization with intact parasitized reticulocytes were successful, while immunization ...
L G, Poels   +3 more
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Genetic identification of antigens protective against coccidia

Parasite Immunology, 2006
SUMMARY The Eimeria species, causative agents of the disease coccidiosis, are genetically complex protozoan parasites endemic in livestock. Drug resistance remains commonplace among the Eimeria, and alternatives to chemotherapeutic control are being sought. Vaccines based upon live formulations of parasites are effective, but production costs are high,
D P, Blake, M W, Shirley, A L, Smith
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