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Immunogenic and protective antigens of Brucella as vaccine candidates
Comparative Immunology, Microbiology and Infectious Diseases, 2019Brucella is an intracellular pathogen that causes abortion in domestic animals and undulant fever in humans. Due to the lack of a human vaccine against brucellosis, animal vaccines play an important role in the management of animal and human brucellosis for decades. Strain 19, RB51 and Rev1 are the approved Brucella spp.
Faramarz, Masjedian Jezi +3 more
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Cloning of the protective antigen gene of Bacillus anthracis
Cell, 1983The tripartite protein toxin of Bacillus anthracis consists of protective antigen (PA), edema factor (EF), and lethal factor (LF). As a first step in developing a more efficacious anthrax vaccine, recombinant plasmids containing the PA gene have been isolated. A library was constructed in the E. coli vector pBR322 from Bam HI-generated fragments of the
M H, Vodkin, S H, Leppla
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Characterization of a new protective antigen of Streptococcus canis
Veterinary Research Communications, 2010Streptococcus canis (S. canis), a lancefield group G streptococcus, is an opportunistic pathogen mainly found in dogs and cats. The study on pathogenesis and protective immune mechanism of S. canis is not clear. A new streptococcal protective antigen (SPA) was first identified from a genomic library of S. canis. SPA of S. canis (SPASc) contained a 1224-
Jiande, Yang +3 more
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[Search for protective antigens of hookworms].
Wiadomosci parazytologiczne, 2006Hookworms are very important blood sucking nematode parasites of humans and domestic animals. The host with a heavy infection can lose almost a cup of blood per day. This may contribute to anemia which is associated with many physical and mental developmental insults.
Marcin Wiśniewski +3 more
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Surface antigens on haemoparasites and their relevance to protective immunity
Biochemical Society Transactions, 1981Labelling by lactoperoxidase-catalysed iodination allowed the characterization of several antigens on the surface of adult Schistosoma mansoni. These antigens are shed into the medium by the worms and are also present on the surfaces of schistosomula and cercariae.
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[Protective antigen of influenza virus].
Nihon rinsho. Japanese journal of clinical medicine, 1998Influenza A virus is unique among human viruses in its capacity to alter the antigenic phenotype with relative ease and evade neutralizing antibodies. This property is ascribed to the accumulation of a series of amino acid changes in the antigenic regions of hemagglutinin (HA) molecule.
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Protective antigens in experimental schistosomiasis
Acta tropica. Supplementum, 1987Capron, A., Pierce, R., Balloul, J.M.
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