Results 111 to 120 of about 17,058,241 (360)

Exploring the interconnectedness of fatigue, depression, anxiety and potential risk and protective factors in cancer patients: a network approach

Journal of behavioral medicine, 2019
Researchers have extensively studied fatigue, depression and anxiety in cancer patients. Several risk and protective factors have been identified for these symptoms.
M. Schellekens, M. Wolvers, M. Schroevers, T. Bootsma, A. Cramer, M. L. van der Lee   +5 more
semanticscholar   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Psychological and Sociodemographic Variables Associated with Increased Anxiety and Anxiety Symptoms in Older Adults: A Scoping Review

Geriatrics
Background/Objectives: There is a high prevalence of anxiety and anxiety symptoms in older adults, which can have cognitive, emotional, and physical repercussions on older adults.
Jesús Enrique Sotelo-Ojeda, Christian Oswaldo Acosta-Quiroz, Raquel García-Flores, Ana Luisa Mónica González-Celis Rangel, Erick Alberto Medina-Jiménez   +4 more
doaj   +1 more source

Modifiable risk and protective factors in disease development, progression and clinical subtypes of Parkinson's disease: What do prospective studies suggest?

Neurobiology of Disease, 2019
Parkinson's disease (PD) is a neurodegenerative disorder whose pathogenesis depends on a combination of genetic and environmental factors. The aim of the present review was to provide an updated description of the findings emerging from prospective ...
D. Belvisi, R. Pellicciari, G. Fabbrini, M. Tinazzi, A. Berardelli, G. Defazio   +5 more
semanticscholar   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Incidence and determinants of stillbirth among women who gave birth in Jimma University specialized hospital, Ethiopia

The Pan African Medical Journal, 2017
INTRODUCTION: Worldwide approximately 2.7 million are stillborn, more than 98% of these occur in developing countries. To address the problem, incidence and determinants of stillbirth must be understood.
Dejene Tilahun, Tsion Assefa
doaj   +1 more source

Intervention strategies for children and adolescent with disorders: from intrapsychic to transactional perspective [PDF]

, 2015
A large amount of studies and clinical evidence document the importance of infancy and early childhood influences on long term developmental trajectories toward mental health or psychopathology (Sameroff, 2000, 2010).
LANGHER, Viviana, S. Cataudella
core  

Identifying Protective Factors in Response to Discriminatory Experiences among Pregnant African American Woman [PDF]

, 2020
Adverse maternal-fetal health outcomes, such as low birth weight and preterm delivery, are disproportionately more likely among African-Americans than Non-Hispanic Whites.
Foster, MD, Krys, Mathew, Effie
core   +1 more source

Risk and Protective Factors for Intimate Partner Violence Against Women: Systematic Review and Meta-analyses of Prospective-Longitudinal Studies

American Journal of Public Health, 2018
Background The estimated lifetime prevalence of physical or sexual intimate partner violence (IPV) is 30% among women worldwide. Understanding risk and protective factors is essential for designing effective prevention strategies.
A. Yakubovich, H. Stöckl, J. Murray, G. Melendez-Torres, J. Steinert, Calla E. Y. Glavin, David K Humphreys   +6 more
semanticscholar   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source