Results 1 to 10 of about 15,507,347 (338)
Entropy in protein folding and in protein—protein interactions
Current Opinion in Structural Biology, 1997 The reduction of conformational entropy is a major barrier that has to be overcome in protein folding and binding. Changes in solvent entropy are also a major factor. Recent advances include clarification of the fundamental issues concerning the separation of entropy into components, the treatment of association entropy in binding, and the role of size
Kim A. Sharp, G.Patrick Brady
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Dendritic cells steering antigen and leukocyte traffic in lymph nodes
FEBS Letters, EarlyView.Dendritic cells are key players in the activation of T cells and their commitment to effector function. In this In a Nutshell Review, we will discuss how dendritic cells guide the trafficking of antigen and leukocytes in the lymph node, thus influencing T‐cell activation processes. Dendritic cells (DCs) play a central role in initiating and shaping the
Enrico Dotta +3 more
wiley +1 more source
Positional proteomics reveals differences in N‐terminal proteoform stability
Molecular Systems Biology, 2016 To understand the impact of alternative translation initiation on a proteome, we performed a proteome‐wide study on protein turnover using positional proteomics and ribosome profiling to distinguish between N‐terminal proteoforms of individual genes.
Daria Gawron +3 more
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Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins
Nature Communications, 2021 RaPID (Random non-standard Peptides Integrated Discovery) enables discovery of small macrocyclic peptides binding desired targets. Here, the authors propose lasso-grafting: the RaPID-derived peptides are implanted onto diverse proteins and maintain both ...
Emiko Mihara +12 more
doaj +1 more source
Protein Sorting: Pulling in the proteins [PDF]
Current Biology, 1995 Two driving mechanisms, one powered by membrane potential and the other a combination of pulling and trapping, seem to be involved in protein import into mitochondria.
Pfanner, Nikolaus, Meijer, Michiel
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FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source
Green protein from locally grown crops (OK-Net EcoFeed Practice Abstract) [PDF]
, 2020 • Choose an appropriate type of green crop, such as clover-grass or alfalfa, with an expected high protein and amino acid content. Consider soil types and weather patterns to grow a crop with a good and high quality yield. • Harvest the field at regular
Ambye-Jensen, Morten +2 more
core
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Preparation of Golgi Membranes from Rat Liver
Bio-Protocol, 2014 This protocol details the isolation of enriched Golgi membranes from rat liver, using discontinuous density gradient centrifugation. This high-yield extraction method is useful for several applications, including immunoprecipitation of solubilised Golgi ...
Carmen Valente +4 more
doaj +1 more source
Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau. [PDF]
, 2018 Small heat shock proteins (sHSPs) are a class of oligomeric molecular chaperones that limit protein aggregation. However, it is often not clear where sHSPs bind on their client proteins or how these protein-protein interactions (PPIs) are regulated. Here,
Agard, David A +8 more
core +2 more sources