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Protein [PDF]

Advances in Nutrition, 2011
Proteins are polymers of amino acids linked via α-peptide bonds. They can be represented as primary, secondary, tertiary, and even quaternary structures, but from a nutritional viewpoint only the primary (amino acid) sequence is of interest. Similarly, although there are many compounds in the body that can be chemically defined as amino acids, we are ...
Malcolm, Watford, Guoyao, Wu
openaire   +5 more sources

Identification of photocrosslinking peptide ligands by mRNA display

Communications Chemistry, 2023
Photoaffinity labelling is a promising method for studying protein-ligand interactions. However, obtaining a specific, efficient crosslinker can require significant optimisation.
Yuteng Wu, M. Teresa Bertran, Dhira Joshi, Sarah L. Maslen, Catherine Hurd, Louise J. Walport   +5 more
doaj   +1 more source

Expression of functional eGFP-fused antigen-binding fragment of ranibizumab in Pichia pastoris [PDF]

BioImpacts, 2022
Introduction: Ranibizumab is a mouse monoclonal antibody fragment antigen-binding (Fab) against human vascular endothelial growth factor-A (VEGF-A), inhibiting angiogenesis.
Shirin Movaghar Asareh, Tahereh Savei, Sareh Arjmand, Seyed Omid Ranaei Siadat, Fataneh Fatemi, Mehrab Pourmadadi, Javad Shabani Shayeh   +6 more
doaj   +1 more source

AA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils

Nature Communications, 2021
Systemic AA amyloidosis is a protein misfolding disease caused by the formation of amyloid fibrils from serum amyloid A (SAA) protein. Here, the authors present the cryo-EM structures of AA amyloid fibrils isolated from mouse tissue and in vitro formed ...
Akanksha Bansal, Matthias Schmidt, Matthies Rennegarbe, Christian Haupt, Falk Liberta, Sabrina Stecher, Ioana Puscalau-Girtu, Alexander Biedermann, Marcus Fändrich   +8 more
doaj   +1 more source

Molecular Characterization and Genotype-Phenotype Correlation of G6PD Mutations in Five Ethnicities of Northern Vietnam

Anemia, 2022
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme disorder and is caused by G6PD gene mutations. To date, more than 400 variants in the G6PD gene have been discovered, and about 160 identified variants are associated with a ...
Thi Thao Ngo, Thinh Huy Tran, Thanh Dat Ta, Thi Phuong Le, Phuoc Dung Nguyen, Mai Anh Tran, The-Hung Bui, Thanh Van Ta, Van Khanh Tran   +8 more
doaj   +1 more source

Association, Conformational Rearrangements and the Reverse Process of Aggregates Dissociation during Apomyoglobin Amyloid Formation

Physchem, 2023
Amyloid formation is linked with serious human diseases that are currently incurable. Usually, in the study of amyloid aggregation, the description of the protein’s association is in focus.
Victor Marchenkov, Vitaly Balobanov, Mariya Majorina, Nelly Ilyina, Ivan Kashparov, Anatoly Glukhov, Natalya Ryabova, Natalya Katina   +7 more
doaj   +1 more source

A human bispecific antibody neutralizes botulinum neurotoxin serotype A

Scientific Reports, 2023
Botulinum neurotoxin (BoNT) shows high lethality and toxicity, marking it as an important biological threat. The only effective post-exposure therapy is botulinum antitoxin; however, such products have great potential for improvement. To prevent or treat
Jiansheng Lu, Yujia Jiang, Jiazheng Guo, Lei Chen, Fujia Liu, Zhiying Li, Xuyang Liu, Peng Du, Yunzhou Yu, Rong Wang, Zhixin Yang   +10 more
doaj   +1 more source

Cryo-EM structure of a functional monomeric Photosystem I from Thermosynechococcus elongatus reveals red chlorophyll cluster

Communications Biology, 2021
Çoruh, Frank et al. report the structure of monomeric Photosystem I from cyanobacteria Thermosynechoccocus elongatus BP-1. They assign monomerization-induced loss of red chlorophylls to a cluster of chlorophylls adjacent to PsaX.
Orkun Çoruh, Anna Frank, Hideaki Tanaka, Akihiro Kawamoto, Eithar El-Mohsnawy, Takayuki Kato, Keiichi Namba, Christoph Gerle, Marc M. Nowaczyk, Genji Kurisu   +9 more
doaj   +1 more source

Structural mechanism of laminin recognition by integrin

Nature Communications, 2021
Recognition of laminin by integrin receptors mediates epithelial cell adhesion to basement membrane. Here, the structures of the α6β1 integrin alone and in complex with three-chain laminin-511 fragment reveal the laminin-integrin interface in molecular ...
Takao Arimori, Naoyuki Miyazaki, Emiko Mihara, Mamoru Takizawa, Yukimasa Taniguchi, Carlos Cabañas, Kiyotoshi Sekiguchi, Junichi Takagi   +7 more
doaj   +1 more source

Influence of Amino Acid Substitutions in ApoMb on Different Stages of Unfolding of Amyloids

Molecules, 2023
To date, most research on amyloid aggregation has focused on describing the structure of amyloids and the kinetics of their formation, while the conformational stability of fibrils remains insufficiently explored.
Natalya Katina, Victor Marchenkov, Natalya Ryabova, Nelly Ilyina, Natalia Marchenko, Vitalii Balobanov, Alexey Finkelstein   +6 more
doaj   +1 more source