Results 21 to 30 of about 10,756,110 (307)
Statistical characterization of therapeutic protein modifications
Scientific Reports, 2017 Peptide mapping with liquid chromatography–tandem mass spectrometry (LC-MS/MS) is an important analytical method for characterization of post-translational and chemical modifications in therapeutic proteins.
Tsung-Heng Tsai +13 more
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Cryo-EM structure of a catalytic amyloid fibril
Scientific Reports, 2023 Catalytic amyloid fibrils are novel types of bioinspired, functional materials that combine the chemical and mechanical robustness of amyloids with the ability to catalyze a certain chemical reaction.
Thomas Heerde +3 more
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Annotation and Curation of the Protein Data Bank [PDF]
, 2009 The Protein Data Bank (PDB) is the worldwide repository for experimentally determined 3D structures of biological macromolecules. Established in 1971 with just seven structures, it presently includes more than 56,000 entries.
Jasmine Young +1 more
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Protein-protein interaction prediction for targeted protein degradation [PDF]
International Journal of Molecular Sciences, 2022 AbstractProtein-protein interactions (PPIs) play a fundamental role in various biological functions; thus, detecting PPI sites is essential for understanding diseases and developing new drugs. PPI prediction is of particular relevance for the development of drugs employing targeted protein degradation, as their efficacy relies on the formation of a ...
Oliver Orasch +5 more
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Biomolecules, 2021 The development of many severe human diseases is associated with the formation of amyloid fibrils. Most of the available information on the process of amyloid formation has been obtained from studies of small proteins and peptides, wherein the features ...
Victor Marchenkov +5 more
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Protein kinase CK2 is widely expressed in follicular, Burkitt and diffuse large B-cell lymphomas and propels malignant B-cell growth. [PDF]
, 2015 Serine-threonine kinase CK2 is highly expressed and pivotal for survival and proliferation in multiple myeloma, chronic lymphocytic leukemia and mantle cell lymphoma.
Agostinelli, C +9 more
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Current Opinion in Structural Biology, 2013 We are proud to present the first edition of the Protein–protein interactions Section of Current Opinion in Structural Biology. The Section is new, but the topic has been present in the journal from the very start. Volume 1, Issue 1, dated February 1991, had a review by Janin entitled Protein–protein interactions and assembly, and others by Bode and ...
Janin, Joel, Bonvin, Alexandre M. J. J.
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Transient protein-protein interactions [PDF]
Protein Engineering Design and Selection, 2011 Transient complexes are crucial for diverse biological processes such as biochemical pathways and signaling cascades in the cell. Here, we give an overview of the transient interactions; the importance of transient interactions as drug targets; and the structural characterization of transient protein-protein complexes based on the geometrical and ...
Saliha Ece, Acuner Ozbabacan +3 more
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Influence of mutations of Val226 on the catalytic rate of haloalkane dehalogenase [PDF]
, 1997 Haloalkane dehalogenase converts haloalkanes to their corresponding alcohols. The 3D structure, reaction mechanism and kinetic mechanism have been studied.
Janssen, Dick B., +3 more
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Minimum energy configurations of the 2-dimensional HP-model of proteins by self-organizing networks [PDF]
, 2002 We use self-organizing maps (SOM) as an efficient tool to find the minimum energy configurations of the 2-dimensional HP-models of proteins. The usage of the SOM for the protein folding problem is similar to that for the Traveling Salesman Problem.
Erman, Burak +2 more
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