Benchmark Evaluation of Protein–Protein Interaction Prediction Algorithms
Molecules, 2021 Protein–protein interactions (PPIs) perform various functions and regulate processes throughout cells. Knowledge of the full network of PPIs is vital to biomedical research, but most of the PPIs are still unknown.
Brandan Dunham, Madhavi K. Ganapathiraju
doaj +1 more source
Preferential attachment in the protein network evolution
, 2003 The Saccharomyces cerevisiae protein-protein interaction map, as well as many natural and man-made networks, shares the scale-free topology. The preferential attachment model was suggested as a generic network evolution model that yields this universal ...
A. Vazquez +8 more
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Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
AligNet: alignment of protein-protein interaction networks
BMC Bioinformatics, 2020 Background All molecular functions and biological processes are carried out by groups of proteins that interact with each other. Metaproteomic data continuously generates new proteins whose molecular functions and relations must be discovered.
Adrià Alcalá +4 more
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A comprehensive statistical study of metabolic and protein-protein interaction network properties
, 2018 Understanding the mathematical properties of graphs underling biological systems could give hints on the evolutionary mechanisms behind these structures.
Gamermann, D., Jaime, R., Triana, J.
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Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Influence of protein abundance on high-throughput protein-protein interaction detection. [PDF]
PLoS ONE, 2009 Experimental protein-protein interaction (PPI) networks are increasingly being exploited in diverse ways for biological discovery. Accordingly, it is vital to discern their underlying natures by identifying and classifying the various types of ...
Joseph Ivanic +3 more
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Deep learning frameworks for protein–protein interaction prediction
Computational and Structural Biotechnology Journal, 2022 Protein-protein interactions (PPIs) play key roles in a broad range of biological processes. The disorder of PPIs often causes various physical and mental diseases, which makes PPIs become the focus of the research on disease mechanism and clinical ...
Xiaotian Hu +3 more
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A bidirectional fluorescent two-hybrid system for monitoring protein–protein interactions
, 2014 Two-hybrid systems have been the cornerstone of research into protein–protein interactions, but these systems typically rely on life/death reporters that put additional selective pressure on the host organism, and potentially lead to false positives ...
Nordgren, Ida Karin, Tavassoli, Ali
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Poly(amidoamine)s synthesis, characterisation and interaction with BSA [PDF]
, 2014 Cationic poly(amidoamine)s (PAAs) were synthesised and characterised by NMR and gel permeation chromatography. Their thermal properties were investigated using thermogravimetric analysis and differential scanning calorimetry.
Akinc +45 more
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