Results 71 to 80 of about 9,193,993 (329)

TagF-mediated repression of bacterial type VI secretion systems involves a direct interaction with the cytoplasmic protein Fha [PDF]

, 2018
The bacterial type VI secretion system (T6SS) delivers effectors into eukaryotic host cells or toxins into bacterial competitor for survival and fitness.
Filloux, A, Lai, E-M, Lin, J-S, Pissaridou, P, Tsai, M-D, Wu, H-H   +5 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The protein-protein interaction ontology: for better representing and capturing the biological context of protein interaction

BMC Genomics, 2021
Background With the rapid increase in the amount of Protein-Protein Interaction (PPI) data, the establishment of an event-centered PPI ontology that contains temporal and spatial vocabularies is urgently needed to clarify PPI biological annotations.
Mansheng Li, Qiang He, Chunyuan Yang, Jie Ma, Fuchu He, Tao Chen, Yunping Zhu   +6 more
doaj   +1 more source

HIPPIE v2.0: enhancing meaningfulness and reliability of protein–protein interaction networks

Nucleic Acids Res., 2016
The increasing number of experimentally detected interactions between proteins makes it difficult for researchers to extract the interactions relevant for specific biological processes or diseases.
Gregorio Alanis-Lobato, Miguel Andrade, Martin H. Schaefer   +2 more
semanticscholar   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

AligNet: alignment of protein-protein interaction networks

BMC Bioinformatics, 2020
Background All molecular functions and biological processes are carried out by groups of proteins that interact with each other. Metaproteomic data continuously generates new proteins whose molecular functions and relations must be discovered.
Adrià Alcalá, Ricardo Alberich, Mercè Llabrés, Francesc Rosselló, Gabriel Valiente   +4 more
doaj   +1 more source

Continuum Electromechanical Modeling of Protein-Membrane Interaction

, 2010
A continuum electromechanical model is proposed to describe the membrane curvature induced by electrostatic interactions in a solvated protein-membrane system.
Alemayehu A. Gorfe, Benzhuo Lu, N. Kikuchi, P. G. Ciarlet, Y. C. Zhou   +4 more
core   +1 more source

Sequence-based prediction of protein protein interaction using a deep-learning algorithm

BMC Bioinformatics, 2017
Protein-protein interactions (PPIs) are critical for many biological processes. It is therefore important to develop accurate high-throughput methods for identifying PPI to better understand protein function, disease occurrence, and therapy design ...
Tanlin Sun, Bo Zhou, L. Lai, Jianfeng Pei   +3 more
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Influence of protein abundance on high-throughput protein-protein interaction detection. [PDF]

PLoS ONE, 2009
Experimental protein-protein interaction (PPI) networks are increasingly being exploited in diverse ways for biological discovery. Accordingly, it is vital to discern their underlying natures by identifying and classifying the various types of ...
Joseph Ivanic, Xueping Yu, Anders Wallqvist, Jaques Reifman   +3 more
doaj   +1 more source