Results 191 to 200 of about 1,854,416 (221)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Predicting protein-protein interactions in the human proteome. [PDF]

Science
Zhang J, Humphreys IR, Pei J, Kim J, Choi C, Yuan R, Durham J, Liu S, Choi HJ, Baek M, Baker D, Cong Q.   +11 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Special Issue: Protein-Protein Interactions: New Perspectives in Drug Discovery. [PDF]

Int J Mol Sci
Szénási T.
europepmc   +1 more source

Correction: ToxoNet: A high confidence map of protein-protein interactions in Toxoplasma gondii. [PDF]

PLoS Comput Biol
Swapna LS, Stevens GC, Sardinha-Silva A, Hu LZ, Brand V, Fusca DD, Wan C, Xiong X, Boyle JP, Grigg ME, Emili A, Parkinson J.   +11 more
europepmc   +1 more source

Protein-protein interactions are a major source of epistasis in genetic interaction networks. [PDF]

Nat Commun
Castellanos-Girouard X, Serohijos AWR, Michnick SW.   +2 more
europepmc   +1 more source

Unraveling the Network Signatures of Oncogenicity in Virus-Human Protein-Protein Interactions. [PDF]

Entropy (Basel)
Zambelli F, Pancaldi V, De Domenico M.
europepmc   +1 more source

Glycopolymers stabilize protein folding and protein-protein interactions via enthalpic interactions. [PDF]

Protein Sci
Richter SM, Brook N, Guseman AJ.
europepmc   +1 more source

Multimodal Learning of Protein-Protein Interactions for Accurate Binding Affinity Prediction. [PDF]

ACS Omega
Mo J, Guo J, Duan H.
europepmc   +1 more source