Results 261 to 270 of about 1,962,138 (310)

Protein-Protein Interactions in Membranes

Protein & Peptide Letters, 2011
In this article we review the current status of our understanding of membrane mediated interactions from theory and experiment. Phenomenological mean field and molecular models will be discussed and compared to recent experimental results from dynamical neutron scattering and atomic force microscopy.
Armstrong, C.L., Sandqvist, E., Rheinstädter, M.C.   +2 more
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Prediction of Protein‐Protein Interactions

Current Protocols in Bioinformatics, 2017
AbstractThe authors provide an overview of physical protein‐protein interaction prediction, covering the main strategies for predicting interactions, approaches for assessing predictions, and online resources for accessing predictions. This unit focuses on the main advancements in each of these areas over the last decade. The methods and resources that
Max, Kotlyar, Andrea E M, Rossos, Igor, Jurisica   +2 more
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Databases for Protein–Protein Interactions

2021
Protein-protein interaction networks have a crucial role in biological processes. Proteins perform multiple functions in forming physical and functional interactions in cellular systems. Information concerning an enormous number of protein interactions in a wide range of species has accumulated and has been integrated into various resources for ...
Natsu, Nakajima, Tatsuya, Akutsu, Ryuichiro, Nakato   +2 more
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Osmolytes and Protein–Protein Interactions

Journal of the American Chemical Society, 2018
Cells survive fluctuations in osmolality by accumulating and depleting highly soluble, usually neutral, small organic compounds. Natural selection has converged on a small set of such molecules, called osmolytes. The biophysical characterization of osmolytes, with respect to proteins, has centered on tertiary structure stability.
Amy E. Rydeen, Eric M. Brustad, Gary J. Pielak   +2 more
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Measuring protein—protein interactions

Current Opinion in Structural Biology, 1998
The binding of one protein to another provokes a variety of biophysical changes that can then be used as a measure of the binding reaction. Optical spectroscopy, particularly fluorescence, is the most flexible technique, but surface plasmon resonance biosensors, microcalorimetry and mass spectroscopy have recently shown significant development.
J H, Lakey, E M, Raggett
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Protein-Protein Interactions of Phosphodiesterases

Current Topics in Medicinal Chemistry, 2019
Background: Phosphodiesterases (PDEs) are enzymes that play a key role in terminating cyclic nucleotides signalling by catalysing the hydrolysis of 3’, 5’- cyclic adenosine monophosphate (cAMP) and/or 3’, 5’ cyclic guanosine monophosphate (cGMP), the second messengers within the cell that transport the signals produced by extracellular signalling ...
Mayasah Y, Al-Nema, Anand, Gaurav
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Decoding Protein-protein Interactions: An Overview

Current Topics in Medicinal Chemistry, 2020
Drug discovery has focused on the paradigm “one drug, one target” for a long time. However, small molecules can act at multiple macromolecular targets, which serves as the basis for drug repurposing. In an effort to expand the target space, and given advances in X-ray crystallography, protein-protein interactions have become an emerging focus area of ...
Olivia Slater, Bethany Miller, Maria Kontoyianni   +2 more
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Protein-Protein Interactions in TRAF3

2007
TNF-receptor-associated factors (TRAFs) are intracellular proteins that bind to the cytoplasmic portion of TNF receptors and mediate downstream signaling. The six known TRAF proteins play overlapping yet distinct roles in controlling immune responses as well as cellular processes such as activation of NF-kappaB and JNK signaling pathways.
Kathryn R, Ely, Ramadurgam, Kodandapani, ShuangDing, Wu   +2 more
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Analyzing Protein–Protein Interaction Networks

Journal of Proteome Research, 2012
The advent of the "omics" era in biology research has brought new challenges and requires the development of novel strategies to answer previously intractable questions. Molecular interaction networks provide a framework to visualize cellular processes, but their complexity often makes their interpretation an overwhelming task.
Koh GC, Porras P, Aranda B, Hermjakob H, Orchard SE.   +4 more
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Protein-Protein Interactions

1954
Publisher Summary This chapter focuses on protein–protein interaction. The unique characteristics of different proteins are developed in the interactions of proteins with each other, with ions, and with nonprotein materials such as lipids, nucleic acids, and carbohydrates.
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