Results 1 to 10 of about 333,854 (331)

Development of the Sensing Platform for Protein Tyrosine Kinase Activity [PDF]

Biosensors, 2021
A miniature tyrosinase-based electrochemical sensing platform for label-free detection of protein tyrosine kinase activity was developed in this study. The developed miniature sensing platform can detect the substrate peptides for tyrosine kinases, such ...
Lan-Yi Wei, Wei Lin, Bey-Fen Leo, Lik-Voon Kiew, Chia-Ching Chang, Chiun-Jye Yuan   +5 more
doaj   +2 more sources

Identification of a fungi-specific lineage of protein kinases closely related to tyrosine kinases.

PLoS ONE, 2014
Tyrosine kinases (TKs) specifically catalyze the phosphorylation of tyrosine residues in proteins and play essential roles in many cellular processes.
Zhongtao Zhao, Qiaojun Jin, Jin-Rong Xu, Huiquan Liu   +3 more
doaj   +2 more sources

The dictyostelium kinome--analysis of the protein kinases from a simple model organism. [PDF]

PLoS Genetics, 2006
Dictyostelium discoideum is a widely studied model organism with both unicellular and multicellular forms in its developmental cycle. The Dictyostelium genome encodes 285 predicted protein kinases, similar to the count of the much more advanced ...
Jonathan M Goldberg, Gerard Manning, Allen Liu, Petra Fey, Karen E Pilcher, Yanji Xu, Janet L Smith   +6 more
doaj   +2 more sources

Role of Vav1, a hematopoietic signal transduction molecule, as an adaptor protein in health and disease

Exploration of Immunology, 2023
The growth and differentiation of normal cells are controlled by protein-tyrosine kinases, which serve as receptors for a wide variety of external signals.
Shulamit Katzav
doaj   +1 more source

PTB domain-directed substrate targeting in a tyrosine kinase from the unicellular choanoflagellate Monosiga brevicollis. [PDF]

PLoS ONE, 2011
Choanoflagellates are considered to be the closest living unicellular relatives of metazoans. The genome of the choanoflagellate Monosiga brevicollis contains a surprisingly high number and diversity of tyrosine kinases, tyrosine phosphatases, and ...
Victoria Prieto-Echagüe, Perry M Chan, Barbara P Craddock, Edward Manser, W Todd Miller   +4 more
doaj   +1 more source

Regulation of Phosphoinositide Levels in the Retina by Protein Tyrosine Phosphatase 1B and Growth Factor Receptor-Bound Protein 14

Biomolecules, 2021
Protein tyrosine kinases and protein phosphatases play a critical role in cellular regulation. The length of a cellular response depends on the interplay between activating protein kinases and deactivating protein phosphatases.
Raju V. S. Rajala, Austin McCauley, Rahul Rajala, Kenneth Teel, Ammaji Rajala   +4 more
doaj   +1 more source

A role for the protein tyrosine phosphatase CD45 in macrophage adhesion through the regulation of paxillin degradation. [PDF]

PLoS ONE, 2013
CD45 is a protein tyrosine phosphatase expressed on all cells of hematopoietic origin that is known to regulate Src family kinases. In macrophages, the absence of CD45 has been linked to defects in adhesion, however the molecular mechanisms involved ...
Joëlle St-Pierre, Hanne L Ostergaard
doaj   +1 more source

Identification of the protein kinases Pyk3 and Phg2 as regulators of the STATc-mediated response to hyperosmolarity [PDF]

, 2014
Cellular adaptation to changes in environmental osmolarity is crucial for cell survival. In Dictyostelium, STATc is a key regulator of the transcriptional response to hyperosmotic stress. Its phosphorylation and consequent activation is controlled by two
A Kortholt, A Kortholt, AA Noegel, Adrian John Harwood, BK Gilsbach, C Blanc, Christoph S. Clemen, CR Thompson, DE Levy, H Kiu, H Kuwayama, H Towbin, J Faix, J Langenick, J Na, Jeffrey G. Williams, Jianbo Na, JM Goldberg, K Adler, KL Williams, L Gebbie, Linh Hai Vu, Ludwig Eichinger, M Brink, M Fukuzawa, M Gamper, MR Lee, NS Lee, P Farbrother, P Gatsios, R Kang, RH Insall, T Araki, T Araki, T Araki, T Araki, Tsuyoshi Araki, UK Laemmli   +37 more
core   +8 more sources

Protein-tyrosine phosphorylation interaction network in Bacillus subtilis reveals new substrates, kinase activators and kinase cross-talk.

Frontiers in Microbiology, 2014
Signal transduction in eukaryotes is generally transmitted through phosphorylation cascades that involve a complex interplay of transmembrane receptors, protein kinases, phosphatases and their targets.
Lei eShi, Lei eShi, Nathalie ePigeonneau, Magali eVentroux, Abderahmane eDerouiche, Abderahmane eDerouiche, Vladimir eBidnenko, Ivan eMijakovic, Ivan eMijakovic, Marie-Françoise eNoirot-Gros   +9 more
doaj   +1 more source

High-throughput profiling of sequence recognition by tyrosine kinases and SH2 domains using bacterial peptide display

eLife, 2023
Tyrosine kinases and SH2 (phosphotyrosine recognition) domains have binding specificities that depend on the amino acid sequence surrounding the target (phospho)tyrosine residue.
Allyson Li, Rashmi Voleti, Minhee Lee, Dejan Gagoski, Neel H Shah   +4 more
doaj   +1 more source