Results 1 to 10 of about 920,915 (421)
Microbial protein-tyrosine kinases. [PDF]
J Biol Chem, 2014 Microbial ester kinases identified in the past 3 decades came as a surprise, as protein phosphorylation on Ser, Thr, and Tyr amino acids was thought to be unique to eukaryotes. Current analysis of available microbial genomes reveals that "eukaryote-like" protein kinases are prevalent in prokaryotes and can converge in the same signaling pathway with ...
Chao JD, Wong D, Av-Gay Y.
europepmc +6 more sources
Protein Tyrosine Kinases: Their Roles and Their Targeting in Leukemia. [PDF]
Cancers (Basel), 2021 Protein kinases constitute a large group of enzymes catalysing protein phosphorylation and controlling multiple signalling events. The human protein kinase superfamily consists of 518 members and represents a complicated system with intricate internal and external interactions.
K Bhanumathy K +5 more
europepmc +6 more sources
BY-kinases: Protein tyrosine kinases like no other. [PDF]
J Biol Chem, 2023 BY-kinases (for bacterial tyrosine kinases) constitute a family of protein tyrosine kinases that are highly conserved in the bacterial kingdom and occur most commonly as essential components of multicomponent assemblies responsible for the biosynthesis, polymerization, and export of complex polysaccharides involved in biofilm or capsule formation.
Hajredini F, Alphonse S, Ghose R.
europepmc +3 more sources
Clinical targeting of mutated and wild-type protein tyrosine kinases in cancer. [PDF]
Mol Cell Biol, 2014 Clinical therapies for cancer have evolved from toxic, nontargeted agents to manageable, highly targeted therapies. Protein tyrosine kinases are a family of signaling molecules implicated in nearly every cancer type and are the foundation for the ...
Drake JM, Lee JK, Witte ON.
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PTB domain-directed substrate targeting in a tyrosine kinase from the unicellular choanoflagellate Monosiga brevicollis. [PDF]
PLoS ONE, 2011 Choanoflagellates are considered to be the closest living unicellular relatives of metazoans. The genome of the choanoflagellate Monosiga brevicollis contains a surprisingly high number and diversity of tyrosine kinases, tyrosine phosphatases, and ...
Victoria Prieto-Echagüe +4 more
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Protein tyrosine kinases in Schistosoma mansoni [PDF]
Memorias do Instituto Oswaldo Cruz, 2006 The identification and description of signal transduction molecules and mechanisms are essential to elucidate Schistosoma mansoni host-parasite interactions and parasite biology.
Diana Bahia +4 more
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Bacterial Protein-Tyrosine Kinases [PDF]
Current Proteomics, 2010 Bacteria and Eukarya share essentially the same family of protein-serine/threonine kinases, also known as the Hanks-type kinases. However, when it comes to protein-tyrosine phosphorylation, bacteria seem to have gone their own way. Bacterial protein-tyrosine kinases (BY-kinases) are bacterial enzymes that are unique in exploiting the ATP/GTP-binding ...
Jers, Carsten +3 more
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The protein tyrosine kinases EpsB and PtkA differentially affect biofilm formation in Bacillus subtilis. [PDF]
Microbiology (Reading), 2014 The Gram-positive soil bacterium Bacillus subtilis is able to choose between motile and sessile lifestyles. The sessile way of life, also referred to as biofilm, depends on the formation of an extracellular polysaccharide matrix and some extracellular ...
Gerwig J +4 more
europepmc +4 more sources
Structural biology of protein tyrosine kinases
Cellular and Molecular Life Sciences, 2006 Our current understanding of the structure, mechanism of action and modes of regulation of the protein tyrosine kinase family owes a great deal to structural biology. Structures are now available for more than 20 different tyrosine kinase domains, many of these in multiple conformational states.
S. Cowan-Jacob
openaire +3 more sources
The dictyostelium kinome--analysis of the protein kinases from a simple model organism. [PDF]
PLoS Genetics, 2006 Dictyostelium discoideum is a widely studied model organism with both unicellular and multicellular forms in its developmental cycle. The Dictyostelium genome encodes 285 predicted protein kinases, similar to the count of the much more advanced ...
Jonathan M Goldberg +6 more
doaj +2 more sources