Results 171 to 180 of about 333,854 (331)

Novel pyrrolo[2,1-f][1,2,4]triazin-4-amines: Dual inhibitors of EGFR and HER2 protein tyrosine kinases

, 2010
Brian E. Fink, Derek Norris, Harold Mastalerz, Ping Chen, Bindu Goyal, Yufen Zhao, Soong‐Hoon Kim, Gregory D. Vite, Francis Y. Lee, Hongjian Zhang, Simone Oppenheimer, John S. Tokarski, Tai W. Wong, Ashvinikumar V. Gavai   +13 more
openalex   +1 more source

Roles of Tyrosine Phosphorylation and Cleavage of Protein Kinase Cδ in Its Protective Effect Against Tumor Necrosis Factor-related Apoptosis Inducing Ligand-induced Apoptosis [PDF]

, 2005
Hana Okhrimenko, Wei Lü, Cunli Xiang, Donghong Ju, Peter M. Blumberg, Ruth Gomel, Gila Kazimirsky, Chaya Brodie   +7 more
openalex   +1 more source

Protein Tyrosine Kinase [PDF]

, 2020
openaire   +1 more source

Type II Alveolar Epithelial Cells Promote Sepsis‐Induced Immunosuppression in Alveolar Macrophages via Exosomal lncRNA Rmrp Release

Advanced Science, EarlyView.
The S100A4/STAT3 axis promotes Rmrp transcription in AEC‐IIs and Rmrp expression in AEC‐II‐derived exosomes. Upon entry into AMs, Rmrp binds to and blocks the ubiquitination and degradation of ZFP36. Increased ZFP36 induced Pfkfb3 mRNA decay by binding to AREs in the 3′ UTR, curbing glycolysis and immune responses of AMs and aggravating SII and ...
Chengxi Liu, Weixia Xuan, Song Cao, Huayun Jia, Qian Wu, Xiaowu Tan, Qijie Wang, Xiaojun Li, Lisha Ding, Yaru Xiong, Meiyun Zhao, Longcheng Zheng, Yunzhu Xi, Jianhua Tan, Rong Li, Xulong Zhang, Wenjie Liu, Xu Wu   +17 more
wiley   +1 more source

Activation of Protein-tyrosine Kinase Pyk2 Is Downstream of Syk in FcεRI Signaling [PDF]

, 1997
Hitoshi Okazaki, Juan Zhang, Majed M. Hamawy, Reuben P. Siraganian   +3 more
openalex   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Structure and activity of the sevenless protein: a protein tyrosine kinase receptor required for photoreceptor development in Drosophila.

, 1989
Michael A. Simon, David D.L. Bowtell, Gerald M. Rubin   +2 more
openalex   +2 more sources

Autoregulatory Mechanisms in Protein-tyrosine Kinases [PDF]

Journal of Biological Chemistry, 1998
S R, Hubbard, M, Mohammadi, J, Schlessinger   +2 more
openaire   +2 more sources

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Evidence that protein tyrosine kinase p56-Lck regulates the activity of phosphatidylinositol-3'-kinase in interleukin-2-dependent T-cells.

, 1993
Russell S. Taichman, Isabel Mérida, Toshihiko Torigoe, Glen N. Gaulton, JC Reed   +4 more
openalex   +1 more source