Results 321 to 330 of about 328,904 (334)

src-related protein tyrosine kinases

1989
Tyrosine protein kinases (TPKs) catalyze the transfer of phosphate groups from nucleotide triphosphates to tyrosine residues on proteins and peptides. While phosphorylation of proteins on tyrosine residues is a well-known post-radiational event detected in different regulatory systems, only a small number of cellular proteins are known substrates for ...
Joseph B. Bolen, André Veillette
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In vitro substrate specificity of protein tyrosine kinases

Molecular and Cellular Biochemistry, 1993
Synthetic peptides such as P60src autophosphorylation site peptides and angiotensin are indiscriminately phosphorylated by protein tyrosine kinases. The observation has led to the general belief that protein tyrosine kinases are highly promiscuous, displaying little in vitro site specificity.
Heung-Chin Cheng, Jerry H. Wang, Isao Matsuura   +2 more
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Structure and function of the protein tyrosine kinases

Progress in Growth Factor Research, 1990
The protein tyrosine kinases (PTKs) are a large and structurally diverse family of enzymes. The conserved catalytic domain held in common by each member of this family is a self-contained 250-300 amino acid unit bearing sixteen highly conserved linear sequence elements, several of which have been shown to be important to the catalytic activity of this ...
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Butein, a Specific Protein Tyrosine Kinase Inhibitor

Biochemical and Biophysical Research Communications, 1998
Butein, a plant polyphenol, was shown to be a specific protein tyrosine kinase inhibitor. This compound inhibited not only the epidermal growth factor (EGF)-stimulated auto-phosphotyrosine level of EGF receptor in HepG2 cells but also tyrosine-specific protein kinase activities of EGF receptor (IC50 = 65 microM) and p60c-src (IC50 = 65 microM) in vitro.
Yang, E.-B., Zhang, K., Mack, P., Cheng, L.Y.   +3 more
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Src-Related Protein Tyrosine Kinases in Hematopoiesis

Blood, 1999
T HE PROLIFERATION and differentiation of blood cell progenitors and precursors are tightly regulated by approximately a dozen different growth factors, which act primarily on hematopoietic cells.[1][1] In addition, growth factors that stimulate a wider variety of cell types, such as insulin ...
Steven M. Anderson, Seth J. Corey
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[29] Inhibition of protein-tyrosine kinases by tyrphostins

1991
Publisher Summary This chapter discusses the inhibition of protein-tyrosine kinases by tyrphostins. Many protein tyrosine kinases (PTKs) catalyze the phosphorylation of tyrosine residues on exogenous substrates and the autophosphorylation of tyrosine residues.
Aviv Gazit, Alexander Levitzki, Nir Osherov, Israel Posner, Chaim Gilon   +4 more
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PROTEIN-TYROSINE KINASES

Annual Review of Biochemistry, 1985
Tony Hunter, Jonathan A. Cooper
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The Src Family of Protein Tyrosine Kinases

1996
The protein tyrosine kinases (PTKs) of the Src family play a central role in regulating cellular development, proliferation, and function in a variety of tissues (reviewed in Mustelin 1994a). Their activity is tightly regulated and constitutive activity of these PTKs results in uncontrolled proliferation and even transformation. It has therefore been a
T. Mustelin, C. Couture
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Protein-tyrosine kinase

1997
Dörte Stephan, Dietmar Schomburg
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Protein Tyrosine Kinases

2006
Frank McCormick, Doriano Fabbro
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