Results 91 to 100 of about 12,507,251 (357)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

FGF12 is a novel component of the nucleolar NOLC1/TCOF1 ribosome biogenesis complex

Cell Communication and Signaling, 2022
Among the FGF proteins, the least characterized superfamily is the group of fibroblast growth factor homologous factors (FHFs). To date, the main role of FHFs has been primarily seen in the modulation of voltage-gated ion channels, but a full picture of ...
Martyna Sochacka, Radoslaw Karelus, Lukasz Opalinski, Daniel Krowarsch, Martyna Biadun, Jacek Otlewski, Malgorzata Zakrzewska   +6 more
doaj   +1 more source

Structural Prediction of Protein–Protein Interactions by Docking: Application to Biomedical Problems [PDF]

, 2018
A huge amount of genetic information is available thanks to the recent advances in sequencing technologies and the larger computational capabilities, but the interpretation of such genetic data at phenotypic level remains elusive.
Barradas-Bautista, Didier, Fernández-Recio, Juan, Pallara, Chiara, Rosell, Mireia   +3 more
core   +2 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Light chain mutations contribute to defining the fibril morphology in systemic AL amyloidosis

Nature Communications
Systemic AL amyloidosis is one of the most frequently diagnosed forms of systemic amyloidosis. It arises from mutational changes in immunoglobulin light chains.
Sara Karimi-Farsijani, Peter Benedikt Pfeiffer, Sambhasan Banerjee, Julian Baur, Lukas Kuhn, Niklas Kupfer, Ute Hegenbart, Stefan O. Schönland, Sebastian Wiese, Christian Haupt, Matthias Schmidt, Marcus Fändrich   +11 more
doaj   +1 more source

Clustering Coefficients of Protein-Protein Interaction Networks

, 2007
The properties of certain networks are determined by hidden variables that are not explicitly measured. The conditional probability (propagator) that a vertex with a given value of the hidden variable is connected to k of other vertices determines all ...
B. Alberts, Gerald A. Miller, Hong Qian, Karol Bomsztyk, Yi Y. Shi   +4 more
core   +1 more source

From Nonspecific DNA–Protein Encounter Complexes to the Prediction of DNA–Protein Interactions [PDF]

, 2009
©2009 Gao, Skolnick. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Sarai, AV Morozov, BW Matthews, BW Matthews, CG Kalodimos, CH Yan, CO Pabo, E Fraenkel, E Katchalski-Katzir, FK Winkler, H Tjong, I Bonnet, IB Kuznetsov, Ilya Vakser, J Gorman, J Skolnick, J Skolnick, JE Donald, Jeffrey Skolnick, JJ Havranek, JS Lamoureux, JS Lamoureux, M Billeter, M Gao, M van Dijk, MJ Sippl, Mu Gao, N Bhardwaj, NC Horton, NM Luscombe, NP Stanford, O Givaty, P Aloy, P Rotkiewicz, PH von Hippel, R Mendez, R Samudrala, RMA Knegtel, S Ahmad, S Jones, SE Halford, SJ Hubbard, TA Robertson, TW Siggers, W Humphrey, WJ Lane, XJ Lu, Y Zhang, Y Zhang, ZJ Liu   +49 more
core   +4 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Allo-network drugs: Extension of the allosteric drug concept to protein-protein interaction and signaling networks [PDF]

, 2013
Allosteric drugs are usually more specific and have fewer side effects than orthosteric drugs targeting the same protein. Here, we overview the current knowledge on allosteric signal transmission from the network point of view, and show that most ...
Csermely, Péter, Nussinov, Ruth, Szilágyi, András   +2 more
core   +2 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source