Results 31 to 40 of about 15,507,347 (338)
Annotation and Curation of the Protein Data Bank [PDF]
, 2009 The Protein Data Bank (PDB) is the worldwide repository for experimentally determined 3D structures of biological macromolecules. Established in 1971 with just seven structures, it presently includes more than 56,000 entries.
Jasmine Young +1 more
core +2 more sources
Cryo-EM structure of a catalytic amyloid fibril
Scientific Reports, 2023 Catalytic amyloid fibrils are novel types of bioinspired, functional materials that combine the chemical and mechanical robustness of amyloids with the ability to catalyze a certain chemical reaction.
Thomas Heerde +3 more
doaj +1 more source
Epitope mapping using mRNA display and a unidirectional nested deletion library [PDF]
, 2005 In vitro selection targeting an anti-polyhistidine monoclonal antibody was performed using mRNA display with a random, unconstrained 27-mer peptide library.
Ja, William W. +2 more
core +1 more source
Application of fourier transform and proteochemometrics principles to protein engineering
BMC Bioinformatics, 2018 Background Connecting the dots between the protein sequence and its function is of fundamental interest for protein engineers. In-silico methods are useful in this quest especially when structural information is not available.
Frédéric Cadet +6 more
doaj +1 more source
Influenza Evolution and H3N2 Vaccine Effectiveness, with Application to the 2014/2015 Season [PDF]
, 2016 Influenza A is a serious disease that causes significant morbidity and mortality, and vaccines against the seasonal influenza disease are of variable effectiveness.
Deem, Michael W., Li, Xi
core +2 more sources
Nucleic Acids Res., 2018 Proteins and their functional interactions form the backbone of the cellular machinery. Their connectivity network needs to be considered for the full understanding of biological phenomena, but the available information on protein–protein associations is
Damian Szklarczyk +11 more
semanticscholar +1 more source
Directed evolution converts subtilisin E into a functional equivalent of thermitase [PDF]
, 1999 We used directed evolution to convert Bacillus subtilis subtilisin E into an enzyme functionally equivalent to its thermophilic homolog thermitase from Thermoactinomyces vulgaris.
Arnold, Frances H., Zhao, Huimin
core +2 more sources
Contextualized Protein-Protein Interactions [PDF]
Patterns, 2021 Protein-protein interaction (PPI) databases are an important bioinformatics resource, yet existing literature-curated databases usually represent cell-type-agnostic interactions, which is at variance with our understanding that protein dynamics are context specific and highly dependent on their environment.
Anthony Federico, Stefano Monti
openaire +4 more sources
Protein complex prediction with AlphaFold-Multimer
bioRxiv, 2021 While the vast majority of well-structured single protein chains can now be predicted to high accuracy due to the recent AlphaFold [1] model, the prediction of multi-chain protein complexes remains a challenge in many cases.
Richard Evans +21 more
semanticscholar +1 more source
Detecting similarities among distant homologous proteins by comparison of domain flexibilities [PDF]
, 2007 Aim of this work is to assess the informativeness of protein dynamics in the detection of similarities among distant homologous proteins. To this end, an approach to perform large-scale comparisons of protein domain flexibilities is proposed. CONCOORD is
Alessandro Pandini +4 more
core +1 more source