Results 31 to 40 of about 11,822,145 (358)

The extracellular interactome of the human adenovirus family reveals diverse strategies for immunomodulation

open access: yesNature Communications, 2016
Viruses interact with their hosts via secreted and membrane-bound proteins to affect host immune responses and virulence. Here the authors contribute to our understanding of this relationship with an extracellular interaction map of human and adenoviral ...
Nadia Martinez-Martin   +11 more
doaj   +1 more source

Time-resolved spectroscopic and electrophysiological data reveal insights in the gating mechanism of anion channelrhodopsin

open access: yesCommunications Biology, 2021
Dreier et al. reports that the anion channelrhodopsin GtACR1 does not undergo a syn-cycle (light adapted ground state) and thus has a more efficient channel behaviour than CrChR2.
Max-Aylmer Dreier   +8 more
doaj   +1 more source

Cryo-EM demonstrates the in vitro proliferation of an ex vivo amyloid fibril morphology by seeding

open access: yesNature Communications, 2022
Here, the authors present the cryo-EM structure of in vitro amyloid fibrils from recombinant SAA1.1 protein that were formed by seeding with fibrils purified from systemic AA amyloidosis tissue.
Thomas Heerde   +12 more
doaj   +1 more source

Protein–Protein and Protein–Membrane Associations in the Lignin Pathway [PDF]

open access: yesThe Plant Cell, 2012
Supramolecular organization of enzymes is proposed to orchestrate metabolic complexity and help channel intermediates in different pathways. Phenylpropanoid metabolism has to direct up to 30% of the carbon fixed by plants to the biosynthesis of lignin precursors. Effective coupling of the enzymes in the pathway thus seems to be required.
Bassard, Jean-Etienne   +13 more
openaire   +5 more sources

Structure of cyanobacterial photosystem I complexed with ferredoxin at 1.97 Å resolution

open access: yesCommunications Biology, 2022
In order to aid the understanding of the electron transfer process within the cyanobacterial photosystem I, its structure - when complexed with Ferredoxin - is determined at 1.97 Å resolution.
Jiannan Li   +10 more
doaj   +1 more source

Protein search for multiple targets on DNA [PDF]

open access: yes, 2015
Protein-DNA interactions are crucial for all biological processes. One of the most important fundamental aspects of these interactions is the process of protein searching and recognizing specific binding sites on DNA.
Alberts B.   +5 more
core   +2 more sources

Morphology of protein–protein interfaces [PDF]

open access: yesStructure, 1998
Most soluble proteins are active as low-number oligomers. Statistical surveys of oligomeric proteins have defined the roles of hydrophobicity and complementarity in the stability of protein interfaces, but tend to average structural features over a diverse set of protein-protein interfaces, blurring information on how individual interfaces are ...
David S. Goodsell   +2 more
openaire   +3 more sources

Dataset concerning GroEL chaperonin interaction with proteins

open access: yesData in Brief, 2016
GroEL chaperonin is well-known to interact with a wide variety of polypeptide chains. Here we show the data related to our previous work (http://dx.doi.org/10.1016/j.pep.2015.11.020 [1]), and concerning the interaction of GroEL with native (lysozyme, α ...
V.V. Marchenkov   +5 more
doaj   +1 more source

Predicting Antibody Developability Profiles Through Early Stage Discovery Screening

open access: yesmAbs, 2020
Monoclonal antibodies play an increasingly important role for the development of new drugs across multiple therapy areas. The term ‘developability’ encompasses the feasibility of molecules to successfully progress from discovery to development via ...
Marc Bailly   +21 more
doaj   +1 more source

Galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling

open access: yesCell Communication and Signaling, 2023
Fibroblast growth factors (FGFs) and their receptors (FGFRs) constitute complex signaling hubs that are crucial for the development and homeostasis of the human body.
Aleksandra Gedaj   +9 more
doaj   +1 more source

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