Results 51 to 60 of about 5,205,392 (267)
Communications Biology, 2023 Biophysical approaches reveal how a mutation in the constant light chain domain of a patient-derived antibody destabilizes the constant domain, prevents the dimerization of the light chain, and makes it more prone to proteolytic cleavage, unleashing the ...
Georg J. Rottenaicher +4 more
doaj +1 more source
Modulators of Protein–Protein Interactions [PDF]
Chemical Reviews, 2014 No ...
Milroy, L. +4 more
openaire +4 more sources
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
Intracellular C3 regulates the immune response to infection via NF-κB signaling
Cellular and Molecular Life SciencesComplement factor C3 is one of the most abundant proteins in the bloodstream and a central part of the complement system. Upon activation, C3 facilitates bacterial recognition and clearance in the extracellular environment.
Katarzyna Kuska +8 more
doaj +1 more source
Positional proteomics reveals differences in N‐terminal proteoform stability
Molecular Systems Biology, 2016 To understand the impact of alternative translation initiation on a proteome, we performed a proteome‐wide study on protein turnover using positional proteomics and ribosome profiling to distinguish between N‐terminal proteoforms of individual genes.
Daria Gawron +3 more
doaj +1 more source
Preparation of Golgi Membranes from Rat Liver
Bio-Protocol, 2014 This protocol details the isolation of enriched Golgi membranes from rat liver, using discontinuous density gradient centrifugation. This high-yield extraction method is useful for several applications, including immunoprecipitation of solubilised Golgi ...
Carmen Valente +4 more
doaj +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Communications ChemistryCovalent drugs can achieve high potency with long dosing intervals. However, concerns remain about side-effects associated with off-target reactivity.
Isabel R. Mathiesen +3 more
doaj +1 more source
Protein—protein binding supersites
PLOS Computational Biology, 2019 The lack of a deep understanding of how proteins interact remains an important roadblock in advancing efforts to identify binding partners and uncover the corresponding regulatory mechanisms of the functions they mediate. Understanding protein-protein interactions is also essential for designing specific chemical modifications to develop new reagents ...
Raji Viswanathan +4 more
openaire +4 more sources
Protein docking prediction using predicted protein-protein interface [PDF]
BMC Bioinformatics, 2012 Many important cellular processes are carried out by protein complexes. To provide physical pictures of interacting proteins, many computational protein-protein prediction methods have been developed in the past. However, it is still difficult to identify the correct docking complex structure within top ranks among alternative conformations.We present ...
Lin, Bin, Kihara, Daisuke
openaire +5 more sources