Results 51 to 60 of about 11,665,453 (372)
Cell Communication and Signaling, 2023 Fibroblast growth factors (FGFs) and their receptors (FGFRs) constitute complex signaling hubs that are crucial for the development and homeostasis of the human body.
Aleksandra Gedaj +9 more
doaj +1 more source
Communications Biology, 2021 Dreier et al. reports that the anion channelrhodopsin GtACR1 does not undergo a syn-cycle (light adapted ground state) and thus has a more efficient channel behaviour than CrChR2.
Max-Aylmer Dreier +8 more
doaj +1 more source
Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins
Nature Communications, 2021 RaPID (Random non-standard Peptides Integrated Discovery) enables discovery of small macrocyclic peptides binding desired targets. Here, the authors propose lasso-grafting: the RaPID-derived peptides are implanted onto diverse proteins and maintain both ...
Emiko Mihara +12 more
doaj +1 more source
Morphology of protein–protein interfaces [PDF]
Structure, 1998 Most soluble proteins are active as low-number oligomers. Statistical surveys of oligomeric proteins have defined the roles of hydrophobicity and complementarity in the stability of protein interfaces, but tend to average structural features over a diverse set of protein-protein interfaces, blurring information on how individual interfaces are ...
David S. Goodsell +2 more
openaire +3 more sources
Near-Wall Aggregation of Amyloidogenic Aβ 1-40 Peptide: Direct Observation by the FRET
Molecules, 2021 The formation of amyloid fibrils is one of the variants of the self-organization of polypeptide chains. For the amyloid aggregation, the solution must be oversaturated with proteins.
Natalia Katina +4 more
doaj +1 more source
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
Nucleic Acids Research, 1997 The BLAST programs are widely used tools for searching protein and DNA databases for sequence similarities. For protein comparisons, a variety of definitional, algorithmic and statistical refinements described here permits the execution time of the BLAST
S. Altschul +6 more
semanticscholar +1 more source
STRING v10: protein–protein interaction networks, integrated over the tree of life
Nucleic Acids Res., 2014 The many functional partnerships and interactions that occur between proteins are at the core of cellular processing and their systematic characterization helps to provide context in molecular systems biology.
Damian Szklarczyk +13 more
semanticscholar +1 more source
Virtual Identification of Essential Proteins Within the Protein Interaction Network of Yeast [PDF]
, 2005 Topological analysis of large scale protein-protein interaction networks (PINs) is important for understanding the organisational and functional principles of individual proteins. The number of interactions that a protein has in a PIN has been observed to be correlated with its indispensability.
arxiv +1 more source
Modulators of Protein–Protein Interactions [PDF]
Chemical Reviews, 2014 No ...
Lech-Gustav Milroy +4 more
openaire +4 more sources
Length, Protein-Protein Interactions, and Complexity [PDF]
, 2004 The evolutionary reason for the increase in gene length from archaea to prokaryotes to eukaryotes observed in large scale genome sequencing efforts has been unclear. We propose here that the increasing complexity of protein-protein interactions has driven the selection of longer proteins, as longer proteins are more able to distinguish among a larger ...
arxiv +1 more source