Results 61 to 70 of about 12,507,251 (357)
Communications Biology, 2023 Biophysical approaches reveal how a mutation in the constant light chain domain of a patient-derived antibody destabilizes the constant domain, prevents the dimerization of the light chain, and makes it more prone to proteolytic cleavage, unleashing the ...
Georg J. Rottenaicher +4 more
doaj +1 more source
Binary Assignments of Amino Acids from Pattern Conservation
, 1997 We develop a simple optimization procedure for assigning binary values to the amino acids. The binary values are determined by a maximization of the degree of pattern conservation in groups of closely related protein sequences.
Irbäck, Anders, Potthast, Frank
core +5 more sources
Uncoupling protein 2: a key player and a potential therapeutic target in vascular diseases [PDF]
, 2017 Uncoupling protein 2 (UCP2) is an inner mitochondrial membrane protein that belongs to the uncoupling protein family and plays an important role in lowering mitochondrial membrane potential and dissipating metabolic energy with prevention of oxidative ...
Forte, Maurizio +6 more
core +2 more sources
Modulators of Protein–Protein Interactions [PDF]
Chemical Reviews, 2014 No ...
Milroy, L. +4 more
openaire +4 more sources
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Intracellular C3 regulates the immune response to infection via NF-κB signaling
Cellular and Molecular Life SciencesComplement factor C3 is one of the most abundant proteins in the bloodstream and a central part of the complement system. Upon activation, C3 facilitates bacterial recognition and clearance in the extracellular environment.
Katarzyna Kuska +8 more
doaj +1 more source
Positional proteomics reveals differences in N‐terminal proteoform stability
Molecular Systems Biology, 2016 To understand the impact of alternative translation initiation on a proteome, we performed a proteome‐wide study on protein turnover using positional proteomics and ribosome profiling to distinguish between N‐terminal proteoforms of individual genes.
Daria Gawron +3 more
doaj +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Communications ChemistryCovalent drugs can achieve high potency with long dosing intervals. However, concerns remain about side-effects associated with off-target reactivity.
Isabel R. Mathiesen +3 more
doaj +1 more source
RosettaBackrub--a web server for flexible backbone protein structure modeling and design. [PDF]
, 2010 The RosettaBackrub server (http://kortemmelab.ucsf.edu/backrub) implements the Backrub method, derived from observations of alternative conformations in high-resolution protein crystal structures, for flexible backbone protein modeling.
Friedland, Gregory F +4 more
core +2 more sources