A Subset of Caveolin-1 Interacts with a Fraction of Acyl-CoA:Cholesterol Acyltransferase 1 (ACAT1/SOAT1) at an Endoplasmic Reticulum Subdomain to Attenuate Cholesteryl Ester Biosynthesis [PDF]
BiomoleculesCaveolin-1 is a scaffolding protein of caveolae, flask-shaped membrane microdomains involved in diverse cellular processes. Caveolae are primarily localized to the plasma membrane, the trans-Golgi network, and mitochondria-associated endoplasmic ...
Catherine C. Y. Chang +4 more
doaj +2 more sources
Type 1 Diabetes-Associated Autoantibodies, Sera and T-Cell Receptor Sequences Recognize Myelin Basic Protein: A Novel Peripheral Diabetic Neuropathy–Multiple Sclerosis Connection [PDF]
Cells(1) Background: Neuropathies are common complications of type 1 diabetes (T1D) and previous research demonstrated concomitant demyelinization involving myelin basic protein (MBP). T1D patients have a significantly increased risk of multiple sclerosis (MS)
Robert Root-Bernstein
doaj +2 more sources
Immunotherapies in Rasmussen’s Encephalitis [PDF]
Pediatric Neurology Briefs, 2004 Corticosteroids, IV immunoglobulins (IVIg), cyclophosphamide, therapeutic plasma exchange (TPE), and protein A IgG immunoadsorption (PAI) were evaluated in 15 patients with confirmed Rasmussen’s encephalitis (RE) and reported from various centers in ...
J Gordon Millichap
doaj +2 more sources
Case Report: Management of a delayed type III hypersensitivity reaction with acute kidney injury in a dog after administration of human serum albumin with immunoadsorption [PDF]
Frontiers in Veterinary ScienceA six-year-old, intact male German Shepherd, weighing 43 kg, was presented with generalized edema formation and acute kidney injury due to a suspected delayed type III hypersensitivity reaction and vasculitis 2 weeks after the administration of human ...
Florian Sänger +4 more
doaj +2 more sources
Performance Evaluation of a HBsAg-Specific Immunoadsorbent Based on a Humanized Anti-HBsAg Monoclonal Antibody [PDF]
BiomedicinesBackground/Objectives: Hepatitis B virus (HBV) infection poses a major global health challenge, with current therapies like nucleos(t)ide analogs and pegylated interferon alpha offering limited functional cure rates due to persistent HBsAg-driven immune ...
Shuangshuang Gao +4 more
doaj +2 more sources
Immunoadsorption versus double-dose methylprednisolone in refractory multiple sclerosis relapses [PDF]
, 2023 Objective: Intravenous methylprednisolone is the standard treatment for a multiple sclerosis relapse; however, this fails to improve symptoms in up to one quarter of patients.
Steffen, F. (Falk) +12 more
core +1 more source
Eluate derived by extracorporal antibody-based immunoadsorption elevates the cytosolic Ca2+ concentration in podocytes via B-2 kinin receptors [PDF]
, 2002 Background/Aim: Patients with idiopathic focal segmental glomerulosclerosis (FSGS) often develop a recurrence of the disease after kidney transplantation.
Pavenstadt, H. +13 more
core +1 more source
The Reuse of Immunoadsorption Columns in ABO-Incompatible Kidney Transplantation Is Efficient: The Swiss Experience. [PDF]
, 2015 BACKGROUND We developed a multicentric Swiss protocol for ABO-incompatible kidney transplantation including immunoadsorption column reuse. The aim of this study was to assess efficacy and safety of immunoadsorption column reuse in ABO-incompatible ...
Binet, Isabelle +15 more
core +3 more sources
, 2009 Cutaneous involvement in dermatomyositis can be the prevalent component of disease, failing to respond to adequate therapies for myositis. In this case report, we describe a patient affected by dermatomyositis, characterized by prevalent skin involvement,
Puccini R +7 more
core +2 more sources
Renal Failure, 2023 Purpose This study aimed to assess efficacy of extracorporeal plasma therapy (EPT), including plasmapheresis (PE), immunoadsorption (IA), low-density lipoprotein apheresis (LDL-A), and lymphocytapheresis (LCAP) for adult native kidney patients with ...
Jing Miao +5 more
doaj +1 more source