Results 141 to 150 of about 33,626 (222)

Rational Design, Synthesis, and Biological Evaluation of New Substituted Dihydropyrimidinones as Antibacterial Agents and β‐Lactamase Inhibitors

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
Novel 1,6‐dihydropyrimidinones act as antibacterial agents and beta‐lactamase inhibitors. Compounds 3d, 3i, and 7b demonstrated enhanced beta‐lactamase inhibition relative to the standard reference, clavulanic acid, demonstrating significant potentiation effects to restore antibiotic efficacy and combat resistant bacterial strains. ABSTRACT A series of
Ahmed M. Soliman, Heba Abdelrasheed Allam, Walaa R. Mahmoud, Bassem H. Naguib   +3 more
wiley   +1 more source

Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease

Cell Proliferation, Volume 59, Issue 8, August 2026.
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik, Muhammad Dilawar, Junguang Liao, Jie Zheng, Qitao Qian, Ming Xu, Sisi Lin, Xiaobo Zhu, Qiuwei Ge, Limin Jin, Guiqian Chen   +10 more
wiley   +1 more source

Evaluation of the Safety, Efficacy and Pharmacokinetics of BGM0504 in Chinese Adults With Type 2 Diabetes: A Multicentre, Randomised, Controlled and Double‐Blind Phase II Trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 7073-7082, August 2026.
ABSTRACT Aim This study aimed to evaluate its safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy in Chinese adults with T2DM and to preliminarily compare its efficacy and safety with semaglutide through multiple subcutaneous injections. Materials and Methods In this multicentre, randomised, placebo‐controlled and semaglutide‐positive‐
Ping Jin, Linong Ji, Yangqing Huang, Haifeng Ding, Daosheng Xie, Xiaohui Jiang, Xuemei Yuan, Zhao Cao, Haibin Zhang, Jiandong Yuan   +9 more
wiley   +1 more source

Periodontitis and Endotoxemia: Clinical and Microbiological Insights

Journal of Clinical Periodontology, Volume 53, Issue 8, Page 1344-1354, August 2026.
ABSTRACT Aim Endotoxemia has been proposed as a link between periodontitis and systemic complications through the translocation of lipopolysaccharide (LPS) from inflamed periodontal sites into the bloodstream. This study aimed to investigate subgingival and serum LPS activities and their correlations with periodontal clinical and microbiological ...
Anbo Dong, Muhammed Manzoor, Jaakko Leskelä, Jukka Putaala, Eija Könönen, Yi Jin, Pirkko Pussinen, Susanna Paju, Svetislav Zaric   +8 more
wiley   +1 more source

Root hair plasticity in cereals under abiotic stress

New Phytologist, Volume 251, Issue 4, Page 1684-1693, August 2026.
An integrative perspective on how to study the regulation of root hair plasticity to increase the resilience of cereals to abiotic stress. Summary Abiotic stress is a constant threat to crop growth and yield in the context of climate change. Root systems that can best adapt their architecture to environmental challenges contribute to enhanced ...
Yaping Zhou, Frank Hochholdinger
wiley   +1 more source

Influence of N‐Functionalization of Amiridine on the Biological Activity of Its Conjugates as Multitarget Agents for Potential Treatment of Alzheimer's Disease

ChemMedChem, Volume 21, Issue 14, 29 July 2026.
New conjugates of amiridine and salicylimine/amine with an N‐acylalkylene spacer were synthesized. N‐acylation of amiridine conjugates leads to a decrease in their protonation, resulting in a substantial reduction in anticholinesterase activity and relative inability to block Aβ42 self‐aggregation compared to previously studied analogs with an N ...
Galina F. Makhaeva, Tatiana Y. Astakhova, Maria V. Grishchenko, Tatiana S. Shteinberg, Nadezhda V. Kovaleva, Natalia P. Boltneva, Elena V. Rudakova, Pavel G. Pronkin, Elena N. Timokhina, Eugene V. Radchenko, Evgeny V. Shchegolkov, Yanina V. Burgart, Victor I. Saloutin, Valery N. Charushin, Rudy J. Richardson   +14 more
wiley   +1 more source

Identification of Pyrazolidine‐3‐One Derivatives as a Novel Structural Scaffold for ATP Synthase Inhibitors

ChemMedChem, Volume 21, Issue 14, 29 July 2026.
Following the discovery of oxadiazin‐5‐ones as partial inhibitors of the ATP synthase, we herein report the synthesis of a library of pyrazolidine‐3‐ones and pyrazol‐3‐ones, designed by reducing the six‐membered N–N heterocycles to five‐membered rings.
Lisa Reichert, Aro Delparente, Ida R. Hipfinger, Lukas Reininger, Ana Pinto Castro, Daniel J. Hubin, Roger Schibli, Amy E. Fraley, Linjing Mu   +8 more
wiley   +1 more source

Eyes Toward the Clinic: Selective Inhibition and Degradation Approaches to Bromodomain‐Containing Proteins

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
The function of bromodomain‐containing proteins in regulating gene transcription is reviewed here, including the development of chemical probes and targeted protein degradation modalities (e.g., PROTACs). This extends to clinical efforts targeting the BET bromodomain‐containing proteins. Challenges of selectivity, future prospects, and the differential
Cole R. Scholtz, William C. K. Pomerantz
wiley   +1 more source

Synthetic Ligands of Myeloid C‐Type Lectin Receptors

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Binding of ligands to C‐type lectin receptors (CLRs) on myeloid cells can lead to an array of cellular responses. Exploitation of these receptors for therapeutic purposes requires high‐affinity ligands. This review surveys the diversity of synthetic ligands of myeloid CLRs in the context of binding, signaling, and downstream effects, as well as ...
James Suri, Bernd Lepenies
wiley   +1 more source

Reversible S-palmitoylation of C4 protein encoded by TYLCCxV orchestrates geminiviral pathogenesis. [PDF]

Stress Biol
Xie Y, Zhao M, Liu X, Yan J, Yang W, Chen Y, Yang M, Wang X, Fu S, Zhou X.   +9 more
europepmc   +1 more source