Results 31 to 40 of about 33,626 (222)
SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a
eLife, 2017 Ras proteins play vital roles in numerous biological processes and Ras mutations are found in many human tumors. Understanding how Ras proteins are regulated is important for elucidating cell signaling pathways and identifying new targets for treating ...
Hui Jing +6 more
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Biochemical Society Transactions, 1989 info:eu-repo/semantics ...
Saermark, T, Bex, Françoise
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On the Role of Acylation of Transmembrane Proteins [PDF]
Biophysical Journal, 2010 Acylation is a frequent means to ensure membrane association of a variety of soluble proteins in living cells. However, many transmembrane proteins are palmitoylated, indicating that this posttranslational modification may also serve as a means to regulate protein trafficking. Based on coarse-grained membrane simulations, we find that protein acylation
Morozova, Diana, Weiss, Matthias
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Versatility of Acyl-Acyl Carrier Protein Synthetases
Chemistry & Biology, 2014 The acyl carrier protein (ACP) requires posttranslational modification with a 4'-phosphopantetheine arm for activity, and this thiol-terminated modification carries cargo between enzymes in ACP-dependent metabolic pathways. We show that acyl-ACP synthetases (AasSs) from different organisms are able to load even, odd, and unnatural fatty acids onto E ...
Beld, Joris +2 more
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Acylated proteins in Acholeplasma laidlawii [PDF]
Journal of Bacteriology, 1985 The covalent modification of membrane proteins by long-chain fatty acids was determined in two strains of Acholeplasma laidlawii by one-dimensional gel electrophoresis of radiolabeled membranes. Of the more than 50 membrane polypeptides detected, approximately 30 were labeled with [3H]palmitate, whereas covalent binding of [3H]oleate to membrane ...
C E, Dahl, N C, Sacktor, J S, Dahl
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Fatty acid acylation of proteins: specific roles for palmitic, myristic and caprylic acids
Oilseeds and fats, crops and lipids, 2016 Fatty acid acylation of proteins corresponds to the co- or post-translational covalent linkage of an acyl-CoA, derived from a fatty acid, to an amino-acid residue of the substrate protein.
Rioux Vincent
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Assaying protein palmitoylation in plants
Plant Methods, 2008 Background Protein S-acylation (also known as palmitoylation) is the reversible post-translational addition of acyl lipids to cysteine residues in proteins through a thioester bond. It allows strong association with membranes.
Taylor Laura +2 more
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Biomolecules, 2021 The glutarylation of lysine residues in proteins attracts attention as a possible mechanism of metabolic regulation, perturbed in pathologies. The visualization of protein glutarylation by antibodies specific to ε-glutaryl-lysine residues may be ...
Artem V. Artiukhov +9 more
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mSystems, 2020 Cholesterol of the host macrophage membrane is vital for mycobacterial infection, replication, and persistence. During chronic infection within host lung tissues, cholesterol facilitates the phagocytosis of mycobacteria into macrophages.
Jun-Yu Xu +6 more
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Acyl Carrier Protein in Mycoplasmas [PDF]
Journal of Bacteriology, 1973 Acyl carrier protein (ACP) activity was determined by the malonyl-coenzyme A–CO 2 exchange reaction. It was highest in Acholeplasma laidlawii , lower in A. granularum , and lowest in A. axanthum . The sterol-requiring Mycoplasma
S, Rottem, O, Muhsam-Peled, S, Razin
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