Results 181 to 190 of about 287,910 (304)

Impact of Protein Aggregates on Sporulation and Germination of Bacillus subtilis. [PDF]

Microorganisms, 2023
Mortier J, Cambré A, Schack S, Christie G, Aertsen A.   +4 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Quantitative analysis of autophagic flux reveals radiation-induced activation of SQSTM1-mediated degradation of protein aggregates and ER-phagy. [PDF]

J Radiat Res
Moriwaki T, Masuda T.
europepmc   +1 more source

Label-free identification of protein aggregates using deep learning. [PDF]

Nat Commun, 2023
Ibrahim KA, Grußmayer KS, Riguet N, Feletti L, Lashuel HA, Radenovic A.   +5 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Optofluidic Waveguides for the Label-Free Study of Silk Protein Aggregates. [PDF]

ACS Omega
Heck JR, Toprakcioglu Z, Naegele TE, Frosz MH, Knowles TPJ, Euser TG.   +5 more
europepmc   +1 more source

Solid-to-liquid phase transition in the dissolution of cytosolic misfolded-protein aggregates. [PDF]

iScience, 2023
Tomaszewski A, Wang R, Sandoval E, Zhu J, Liu J, Li R.   +5 more
europepmc   +1 more source

Proteins aggregate not [PDF]

Nature Nanotechnology, 2018
openaire   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Distinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress [PDF]

Mitochondria consist of hundreds of proteins, most of which are inaccessible to the proteasomal quality control system of the cytosol. How cells stabilize the mitochondrial proteome during challenging conditions remains poorly understood.
Schneckmann, Tim, Bökenkamp, Jan-Eric, Räschle, Markus, Storchová, Zuzana, Bertgen, Lea, Koch, Christian, Herrmann, Johannes Martin   +6 more
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