Results 221 to 230 of about 486,105 (348)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Characterization of folding intermediates of a domain-swapped protein by solid-state NMR spectroscopy [PDF]

, 2007
Baldus, M., Boeckmann, A., Etzkorn, M., Penin, F., Riedel, D.   +4 more
core   +2 more sources

Protein Aggregates in Heterozygous Alpha-1 Antitrypsin Phenotype Is a Marker for Progressive Disease. [PDF]

Gastro Hep Adv
Marek GW, Malhi H.
europepmc   +1 more source

Cluster analysis for localisation-based data sets: dos and don'ts when quantifying protein aggregates. [PDF]

Front Bioinform, 2023
Panconi L, Owen DM, Griffié J.
europepmc   +1 more source

STUDY OF THE PROCESS/PRODUCT RELATIONSHIP DURING THE PRODUCTION OF FOOD FOAMS STABILIZED BY WHEY PROTEIN AGGREGATES

, 2009
I. Nicorescu
openalex   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Prions and protein aggregates as pathogens, self-propagating structures, biomarkers, and therapeutic targets. [PDF]

Microbiol Mol Biol Rev
Caughey B, Artikis E, Shoup D, Orrú CD, Alam P, Parveen S, King S, Soukup J, Hughson AG, Priola SA.   +9 more
europepmc   +1 more source

Protein Aggregates in Inhaled Biologics: Challenges and Considerations. [PDF]

J Pharm Sci, 2023
Ibrahim M, Wallace I, Ghazvini S, Manetz S, Cordoba-Rodriguez R, Patel SM.   +5 more
europepmc   +1 more source

Different effects of L‐arginine on protein refolding: Suppressing aggregates of hydrophobic interaction, not covalent binding [PDF]

, 2008
Jing Chen, Yongdong Liu, Yinjue Wang, Hong Ding, Zhiguo Su   +4 more
openalex   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source