Results 251 to 260 of about 737,165 (295)

Interface-mediated protein aggregation

Chemical Communications, 2023
Interfaces play a pivotal role in governing the assembly and aggregation of biopolymers, providing valuable insights into functions of biopolymer materials. A range of exquisite structures are formed through well-planned interactions between biological components and surfaces or interfaces.
Fei Tao, Qian Han, Peng Yang
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Protein aggregation and prionopathies

Pathologie Biologie, 2014
Prion protein and prion-like proteins share a number of characteristics. From the molecular point of view, they are constitutive proteins that aggregate following conformational changes into insoluble particles. These particles escape the cellular clearance machinery and amplify by recruiting the soluble for of their constituting proteins.
M, Renner, R, Melki
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Mechanisms of Protein Aggregation

Current Pharmaceutical Biotechnology, 2009
Aggregation or reversible self-association of protein therapeutics can arise through a number of different mechanisms. Five common aggregation mechanisms are described and their relations to manufacturing processes to suppress and remove aggregates are discussed.
John S, Philo, Tsutomu, Arakawa
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Protein aggregates caught stalling

Nature, 2018
Low-complexity protein aggregates are a hallmark of neurodegeneration. High-resolution snapshots of the structure of one such aggregate offer an unprecedented view of how these proteins disrupt crucial cellular functions. Low-complexity protein aggregates are a hallmark of neurodegeneration.
Laura, Pontano Vaites, J Wade, Harper
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Protein Misfolding and Aggregation

Biotechnology Progress, 2008
Interest in the problem of protein misfolding and aggregation has exploded in recent years for two reasons: (1) the sharp rise in the number and volume of therapeutic proteins produced commercially and (2) the recognition of the central role of protein aggregates in degenerative diseases.
Regina M, Murphy, Brent S, Kendrick
openaire   +2 more sources

β-Amyloid Protein Aggregation

2007
The beta-amyloid peptide aggregates via a nucleation pathway where micellar aggregates propagate to form oligomers (protofibrils), which then polymerize into insoluble fibrils. This fibrillogenic process has been linked to the pathogenesis associated with Alzheimer's disease.
Marcus A, Etienne, Nadia J, Edwin, Jed P, Aucoin, Paul S, Russo, Robin L, McCarley, Robert P, Hammer   +5 more
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DNAJ Proteins and Protein Aggregation Diseases

Current Topics in Medicinal Chemistry, 2013
Many neurodegenerative diseases are late onset diseases, associated with aggregation of proteins, implying that aged cells are more susceptible to proteotoxic stress. It is known that with aging, there is a decline in the functionality of chaperone networks and on the other hand, accumulation of damaged proteins occurs.
Vaishali, Kakkar, Louis C B, Prins, Harm H, Kampinga   +2 more
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Protein aggregation

International Journal of Biological Macromolecules, 2017
Ipsita, Roy, Boris I, Kurganov
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Physicochemical Principles of Protein Aggregation

2013
This chapter provides a theoretical framework on the quantitative description of protein aggregation. The reader is provided with an overview of the fundamental theory of linear and helical polymers, as well as an introduction on the parameters governing evolution of aggregates over time.
Bolognesi B., Tartaglia G. G.
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Protein aggregation: An overview

In order for an ordered protein to perform its specific function, it must have a specific molecular structure. Information about this structure is encoded in the protein's amino acid sequence. The unique functional state is achieved as a result of a specific process, known as protein folding. However, as a result of partial or complete unfolding of the
Bahareh, Dabirmanesh, Khosro, Khajeh, Vladimir N, Uversky   +2 more
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